FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040874900> ?p ?o ?g. }

• W3040874900 endingPage "4867" @default.
• W3040874900 startingPage "4867" @default.
• W3040874900 abstract "Stem cells are highly important in biology due to their unique innate ability to self-renew and differentiate into other specialised cells. In a neurological context, treating major injuries such as traumatic brain injury, spinal cord injury and stroke is a strong basis for research in this area. Mesenchymal stem cells (MSC) are a strong candidate because of their accessibility, compatibility if autologous, high yield and multipotency with a potential to generate neural cells. With the use of small-molecule chemicals, the neural induction of stem cells may occur within minutes or hours. Isobutylmethyl xanthine (IBMX) has been widely used in cocktails to induce neural differentiation. However, the key molecular mechanisms it instigates in the process are largely unknown. In this study we showed that IBMX-treated mesenchymal stem cells induced differentiation within 24 h with the unique expression of several key proteins such as Adapter protein crk, hypoxanthine-guanine phosphoribosyltransferase, DNA topoisomerase 2-beta and Cell division protein kinase 5 (CDK5), vital in linking signalling pathways. Furthermore, the increased expression of basic fibroblast growth factor in treated cells promotes phosphatidylinositol 3-kinase (PI3K), mitogen-activated protein kinase (MAPK) cascades and GTPase–Hras interactions. Bioinformatic and pathway analyses revealed upregulation in expression and an increase in the number of proteins with biological ontologies related to neural development and substructure formation. These findings enhance the understanding of the utility of IBMX in MSC neural differentiation and its involvement in neurite substructure development." @default.
• W3040874900 created "2020-07-16" @default.
• W3040874900 creator A5015748499 @default.
• W3040874900 creator A5033959596 @default.
• W3040874900 creator A5085584281 @default.
• W3040874900 date "2020-07-09" @default.
• W3040874900 modified "2023-10-06" @default.
• W3040874900 title "Molecular Mechanisms Involved in Neural Substructure Development during Phosphodiesterase Inhibitor Treatment of Mesenchymal Stem Cells" @default.
• W3040874900 cites W1486027616 @default.
• W3040874900 cites W1964533091 @default.
• W3040874900 cites W1965235388 @default.
• W3040874900 cites W1968036386 @default.
• W3040874900 cites W1969267464 @default.
• W3040874900 cites W1969417329 @default.
• W3040874900 cites W1969619562 @default.
• W3040874900 cites W1974380358 @default.
• W3040874900 cites W1975269220 @default.
• W3040874900 cites W1975952141 @default.
• W3040874900 cites W1977722786 @default.
• W3040874900 cites W1977833857 @default.
• W3040874900 cites W1978405668 @default.
• W3040874900 cites W1986651814 @default.
• W3040874900 cites W1987695717 @default.
• W3040874900 cites W1990419270 @default.
• W3040874900 cites W1996243257 @default.
• W3040874900 cites W2002371960 @default.
• W3040874900 cites W2005848913 @default.
• W3040874900 cites W2006986081 @default.
• W3040874900 cites W2009951375 @default.
• W3040874900 cites W2010584887 @default.
• W3040874900 cites W2015606150 @default.
• W3040874900 cites W2015660738 @default.
• W3040874900 cites W2016850259 @default.
• W3040874900 cites W2023239299 @default.
• W3040874900 cites W2027075528 @default.
• W3040874900 cites W2027831359 @default.
• W3040874900 cites W2029829796 @default.
• W3040874900 cites W2035549157 @default.
• W3040874900 cites W2045574035 @default.
• W3040874900 cites W2046926080 @default.
• W3040874900 cites W2051392943 @default.
• W3040874900 cites W2053522181 @default.
• W3040874900 cites W2055613750 @default.
• W3040874900 cites W2061462051 @default.
• W3040874900 cites W2064820956 @default.
• W3040874900 cites W2073692210 @default.
• W3040874900 cites W2075227275 @default.
• W3040874900 cites W2082018267 @default.
• W3040874900 cites W2088670027 @default.
• W3040874900 cites W2089253049 @default.
• W3040874900 cites W2096221523 @default.
• W3040874900 cites W2098663813 @default.
• W3040874900 cites W2104509220 @default.
• W3040874900 cites W2104968232 @default.
• W3040874900 cites W2108117531 @default.
• W3040874900 cites W2109162737 @default.
• W3040874900 cites W2119254748 @default.
• W3040874900 cites W2123400942 @default.
• W3040874900 cites W2124809007 @default.
• W3040874900 cites W2125948664 @default.
• W3040874900 cites W2128375499 @default.
• W3040874900 cites W2128907108 @default.
• W3040874900 cites W2135376726 @default.
• W3040874900 cites W2135711029 @default.
• W3040874900 cites W2137672131 @default.
• W3040874900 cites W2155446916 @default.
• W3040874900 cites W2159999899 @default.
• W3040874900 cites W2161857065 @default.
• W3040874900 cites W2166661372 @default.
• W3040874900 cites W2171602378 @default.
• W3040874900 cites W2337260595 @default.
• W3040874900 cites W2408075767 @default.
• W3040874900 cites W2602609341 @default.
• W3040874900 cites W2607444689 @default.
• W3040874900 cites W2746347254 @default.
• W3040874900 cites W2748228164 @default.
• W3040874900 cites W2802695338 @default.
• W3040874900 cites W2807514357 @default.
• W3040874900 cites W2895961228 @default.
• W3040874900 cites W2902465418 @default.
• W3040874900 cites W2913192109 @default.
• W3040874900 cites W3009832800 @default.
• W3040874900 cites W4211163766 @default.
• W3040874900 cites W4244231389 @default.
• W3040874900 cites W82040228 @default.
• W3040874900 doi "https://doi.org/10.3390/ijms21144867" @default.
• W3040874900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7402296" @default.
• W3040874900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32660142" @default.
• W3040874900 hasPublicationYear "2020" @default.
• W3040874900 type Work @default.
• W3040874900 sameAs 3040874900 @default.
• W3040874900 citedByCount "8" @default.
• W3040874900 countsByYear W30408749002021 @default.
• W3040874900 countsByYear W30408749002022 @default.
• W3040874900 countsByYear W30408749002023 @default.
• W3040874900 crossrefType "journal-article" @default.
• W3040874900 hasAuthorship W3040874900A5015748499 @default.
• W3040874900 hasAuthorship W3040874900A5033959596 @default.

• next