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• W3040877059 abstract "(Cancer Cell 36, 444–457.e1–e7; October 14, 2019) In Figure 3E of the original article, the authors showed a western blot of different Ba/F3 cell lines expressing various HER2 exon 20 mutations. It was recently brought to the authors’ attention that there was an extra lane on the western blot and that the labels on the blot were unclearly labeled. The unintentional error was that the last lane of the western blot for HER2 (top row) contained a positive control cell line, H1781, with known expression of HER2 that was not cropped from the image, and the labels were shifted incorrectly. This error has now been corrected in the article online. While this correction does not affect the findings or the conclusions of the study, the authors would like to apologize for this error and any confusion that it may have caused for readers.Figure 3E. The Most Common HER2 Variants in the Tyrosine Kinase Domain are Activating Mutations (Original)View Large Image Figure ViewerDownload Hi-res image Download (PPT) Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 ActivityRobichaux et al.Cancer CellOctober 3, 2019In BriefRobichaux et al. show that ERBB2 mutation hotspots vary across human tumor types, which affect the volume of the HER2 TKI binding pocket and dictate drug sensitivity. Poziotinib is the most potent HER2 TKI among those tested. Moreover, poziotinib enhances T-DM1 efficacy by increasing the cell-surface HER2 level. Full-Text PDF Open Archive" @default.
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• W3040877059 date "2020-03-01" @default.
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• W3040877059 title "Pan-Cancer Landscape and Analysis of ERBB2 Mutations Identifies Poziotinib as a Clinically Active Inhibitor and Enhancer of T-DM1 Activity" @default.
• W3040877059 doi "https://doi.org/10.1016/j.ccell.2020.03.003" @default.
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