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• W3040880835 abstract "It is important to find biomarkers associated with transition to illness in individuals at clinical high-risk for psychosis (CHR). Here, we use free-water imaging, an advanced diffusion MRI technique, to identify white matter alterations in the brains of CHR subjects who subsequently develop psychosis (CHR-P) compared to those who do not (CHR-NP).Twenty-four healthy controls (HC) and 30 CHR individuals, 8 of whom converted to schizophrenia after a mean follow-up of 15.16 months, received baseline MRI scans. Maps of fractional anisotropy (FA), FA of cellular tissue (FAT), and extracellular free-water (FW) were extracted using tract-based spatial statistics after which voxel-wise non-parametric group statistics and correlations with symptom severity were performed.There were no significant differences between HCs and the combined CHR group. However, prior to conversion, CHR-P showed widespread lower FA compared to CHR-NP (pFWE < 0.05). FA changes in CHR-P were associated with significantly lower FAT and higher FW, compared to CHR-NP. Positive symptoms correlated significantly with diffusion parameters in similar regions as those discriminating CHR-P from CHR-NP.Our study suggests that cellular (FAT) and extracellular (FW) white matter alterations are associated with positive symptom severity and indicate an elevated illness risk among CHR individuals." @default.
• W3040880835 created "2020-07-16" @default.
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• W3040880835 date "2020-07-09" @default.
• W3040880835 modified "2023-10-16" @default.
• W3040880835 title "Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis" @default.
• W3040880835 cites W177922368 @default.
• W3040880835 cites W188359927 @default.
• W3040880835 cites W1972369039 @default.
• W3040880835 cites W1972578501 @default.
• W3040880835 cites W1986508264 @default.
• W3040880835 cites W1990043440 @default.
• W3040880835 cites W1993889588 @default.
• W3040880835 cites W1997161422 @default.
• W3040880835 cites W2000250568 @default.
• W3040880835 cites W2016505753 @default.
• W3040880835 cites W2024654275 @default.
• W3040880835 cites W2026616100 @default.
• W3040880835 cites W2039306570 @default.
• W3040880835 cites W2039335406 @default.
• W3040880835 cites W2040459715 @default.
• W3040880835 cites W2042755650 @default.
• W3040880835 cites W2043200458 @default.
• W3040880835 cites W2044486633 @default.
• W3040880835 cites W2046557060 @default.
• W3040880835 cites W2049973822 @default.
• W3040880835 cites W2052644075 @default.
• W3040880835 cites W2079283517 @default.
• W3040880835 cites W2080919625 @default.
• W3040880835 cites W2081242825 @default.
• W3040880835 cites W2085204955 @default.
• W3040880835 cites W2091960711 @default.
• W3040880835 cites W2093810348 @default.
• W3040880835 cites W2102391253 @default.
• W3040880835 cites W2104309828 @default.
• W3040880835 cites W2109435900 @default.
• W3040880835 cites W2112488255 @default.
• W3040880835 cites W2119465468 @default.
• W3040880835 cites W2126693856 @default.
• W3040880835 cites W2136145485 @default.
• W3040880835 cites W2140606211 @default.
• W3040880835 cites W2141645427 @default.
• W3040880835 cites W2145326812 @default.
• W3040880835 cites W2150667092 @default.
• W3040880835 cites W2158329357 @default.
• W3040880835 cites W2169624887 @default.
• W3040880835 cites W2176395883 @default.
• W3040880835 cites W2192825006 @default.
• W3040880835 cites W2198642455 @default.
• W3040880835 cites W2207056170 @default.
• W3040880835 cites W2213154417 @default.
• W3040880835 cites W2264410210 @default.
• W3040880835 cites W2307232592 @default.
• W3040880835 cites W2326538877 @default.
• W3040880835 cites W2329582511 @default.
• W3040880835 cites W2333925235 @default.
• W3040880835 cites W2341083729 @default.
• W3040880835 cites W2345533648 @default.
• W3040880835 cites W2399060753 @default.
• W3040880835 cites W2461295243 @default.
• W3040880835 cites W2515260332 @default.
• W3040880835 cites W2595474555 @default.
• W3040880835 cites W2599082648 @default.
• W3040880835 cites W2610976564 @default.
• W3040880835 cites W2618773239 @default.
• W3040880835 cites W2758113150 @default.
• W3040880835 cites W2767050687 @default.
• W3040880835 cites W2768164808 @default.
• W3040880835 cites W2790426335 @default.
• W3040880835 cites W2793140505 @default.
• W3040880835 cites W2799733011 @default.
• W3040880835 cites W2801468677 @default.
• W3040880835 cites W2801644518 @default.
• W3040880835 cites W2887719417 @default.
• W3040880835 cites W2912272156 @default.
• W3040880835 cites W2937543516 @default.
• W3040880835 cites W2955909394 @default.
• W3040880835 cites W2967937185 @default.
• W3040880835 cites W2972663882 @default.
• W3040880835 cites W2996545013 @default.
• W3040880835 cites W3171418018 @default.
• W3040880835 cites W4210963505 @default.
• W3040880835 cites W4235770099 @default.
• W3040880835 cites W4236669865 @default.
• W3040880835 cites W4247665917 @default.
• W3040880835 cites W4297735260 @default.
• W3040880835 cites W560387063 @default.
• W3040880835 doi "https://doi.org/10.1080/15622975.2020.1775890" @default.
• W3040880835 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7798359" @default.

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