Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040895919> ?p ?o ?g. }
- W3040895919 abstract "Abstract Many commonly consumed plants are used as folk medicines, often with unclear molecular mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of voltage-gated potassium (Kv) channels as a therapeutic target for several medicinal plant compounds. Capers - immature flower buds of Capparis spinosa - have been consumed for food and medicinal purposes for millennia. Here, we show that caper extract hyperpolarizes cells expressing KCNQ1 or KCNQ2/3 Kv channels. Capers are the richest known natural source of quercetin, the most consumed dietary flavonoid. Quercetin potentiated KCNQ1/KCNE1, KCNQ2/3 and KCNQ4 currents but, unusually, not KCNQ5. Strikingly, quercetin augmented both activation and inactivation of KCNQ1, via a unique KCNQ activation mechanism involving sites atop the voltage sensor and in the pore. The findings uncover a novel potential molecular basis for therapeutic effects of quercetin-rich foods and a new chemical space for atypical modes of KCNQ channel modulation." @default.
- W3040895919 created "2020-07-16" @default.
- W3040895919 creator A5062051181 @default.
- W3040895919 creator A5064189417 @default.
- W3040895919 date "2020-07-08" @default.
- W3040895919 modified "2023-09-26" @default.
- W3040895919 title "The ubiquitous flavonoid quercetin is an atypical KCNQ potassium channel activator" @default.
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- W3040895919 doi "https://doi.org/10.1038/s42003-020-1089-8" @default.
- W3040895919 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7343821" @default.
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