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• W3040897617 abstract "PURPOSE: Following therapy, breast cancer survivors have impaired immune functions which are associated with increased risk of recurrence and infectious diseases. Neutrophils are critical to host protection against infectious diseases. The aim of this study was to use acute exercise as an immunological stressor before and after 16-weeks of exercise training to determine changes in neutrophil functions consistent with a reduced infection risk. METHODS: 16 breast cancer (BC) survivors completed 45 minutes of intermittent cycling at 60% of peak CPX wattage before (BASE) and after 16-weeks (FINAL) of exercise training. Eleven healthy sedentary women (Control) completed the same acute bout of exercise at BASE. Blood was taken at rest (PRE), immediately after (POST) and 1 hour after (1Hr POST) exercise. Neutrophil phagocytosis and oxidative killing of E.coli, and expression of CD16, CXCR2 and TLR4 were assessed by flow cytometry (MFI ± SD). RESULTS: Compared to Controls, at BASE PRE, BC survivors had lower phagocytosis of bacteria (4250±718 v 3991±1232; p=0.03), and elevated oxidative burst (4495±651 v 6254±1434; p=0.005). At BASE, BC survivors’ phagocytic response to acute exercise was impaired. BC survivors PRE to POST phagocytosis was unchanged (p=0.224) while Controls increased 15±20% (p=0.003). BC survivors PRE to 1Hr POST phagocytosis increased by 10±17% (p=0.046) while Controls increased 14±14% (p=0.003). Following training, BC survivor PRE phagocytosis increased from BASE to FINAL by 10% (p=0.08), to similar levels as Controls (p=0.765). BC survivors FINAL PRE to POST phagocytosis increased by 10% (p=0.001) and PRE to 1Hr POST by 11% (p=0.008). Oxidative killing of bacteria was unchanged by acute exercise or exercise training. At BASE, BC survivor expression of CD16 reduced during acute exercise, PRE to 1Hr POST by 9% (p=0.04) which annulled following training. CONCLUSIONS: Following cancer therapy, BC survivors have impaired neutrophil functions at rest and to a stressor, which are improved by 16-weeks of exercise training. The improved phagocytosis of bacteria in BC survivors may represent an intrinsic improvement in neutrophil functions consistent with reduced risk of infectious disease. Supported by Breast Cancer Research Foundation (New York, NY)." @default.
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• W3040897617 date "2020-07-01" @default.
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• W3040897617 title "The Effects Of 16-weeks Of Exercise Training On Neutrophil Functions In Breast Cancer Survivors" @default.
• W3040897617 doi "https://doi.org/10.1249/01.mss.0000670120.65864.a4" @default.
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