FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040914718> ?p ?o ?g. }

• W3040914718 endingPage "127556" @default.
• W3040914718 startingPage "127556" @default.
• W3040914718 abstract "Polybrominated diphenyl ethers (PBDEs) are brominated, persistent and bioaccumulative flame retardants widely used in the manufacture of plastic products. Decabromodiphenyl ether (BDE-209) is the most prevalent PBDE in the atmosphere and found in human blood, breast milk and umbilical cord. In vitro studies showed that BDE-209 interferes with murine melanoma cells (B16F10), modulating cell death rates, proliferation and migration, important events for cancer progression. In order to evaluate if BDE-209 modulates metastasis formation in murine models, C57BL/6 mice were exposed to BDE-209 (0.08, 0.8 and 8 μg⁄kg) via gavage (5-day intervals for 45 days) (9 doses in total). Then, mice were inoculated with melanoma cells (B16–F10) at caudal vein receiving 4 additional doses of BDE-209. At 20th day post-cell inoculation, blood, lung, liver, kidney and brain were sampled for hematological, biochemical and morphological analyses. The slightly higher levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in the blood and pro-oxidant state in the liver of BDE-exposed mice indicated liver damage. Although the in vivo approach is for metastasis formation in the lung, they were unexpectedly observed in non-target organs (liver, brain, kidney and gonads). The similarity test showed high proximity among individuals from the control and a dissimilarity index between the control and exposed groups. The present data corroborate the known hepatotoxicity of BDE-209 to mice (C57BL/6) and demonstrate for the first time the increase of metastatic dissemination of B16F10 cells in vivo due to previous and continuous BDE-209 exposure, revealing possible implications of this organic compound with melanoma malignancy related traits. • BDE-209 increase the incidence of metastases in organs of mice. • The occurrence of metastases in non-target organ was an unexpected finding. • The exposure to BDE-209 favor the in vivo metastatic spread of melanoma. • BDE-209 possibly is implicated with melanoma malignancy related traits." @default.
• W3040914718 created "2020-07-16" @default.
• W3040914718 creator A5005276291 @default.
• W3040914718 creator A5009378794 @default.
• W3040914718 creator A5019787655 @default.
• W3040914718 creator A5021043590 @default.
• W3040914718 creator A5033000817 @default.
• W3040914718 creator A5038089792 @default.
• W3040914718 creator A5043399981 @default.
• W3040914718 creator A5050606570 @default.
• W3040914718 creator A5059817117 @default.
• W3040914718 creator A5091880685 @default.
• W3040914718 date "2020-12-01" @default.
• W3040914718 modified "2023-10-18" @default.
• W3040914718 title "Oral exposure to BDE-209 modulates metastatic spread of melanoma in C57BL/6 mice inoculated with B16–F10 cells" @default.
• W3040914718 cites W1521314285 @default.
• W3040914718 cites W1970453663 @default.
• W3040914718 cites W1971917469 @default.
• W3040914718 cites W1973758764 @default.
• W3040914718 cites W1984057092 @default.
• W3040914718 cites W1985631456 @default.
• W3040914718 cites W1987227107 @default.
• W3040914718 cites W1996635192 @default.
• W3040914718 cites W2007185373 @default.
• W3040914718 cites W2019932545 @default.
• W3040914718 cites W2023017386 @default.
• W3040914718 cites W2028489790 @default.
• W3040914718 cites W2031211844 @default.
• W3040914718 cites W2033278321 @default.
• W3040914718 cites W2038396676 @default.
• W3040914718 cites W2040565479 @default.
• W3040914718 cites W2043506893 @default.
• W3040914718 cites W2058495860 @default.
• W3040914718 cites W2061333433 @default.
• W3040914718 cites W2063576996 @default.
• W3040914718 cites W2066411725 @default.
• W3040914718 cites W2067521905 @default.
• W3040914718 cites W2074469498 @default.
• W3040914718 cites W2082657254 @default.
• W3040914718 cites W2094156327 @default.
• W3040914718 cites W2100182943 @default.
• W3040914718 cites W2137815066 @default.
• W3040914718 cites W2153124797 @default.
• W3040914718 cites W2153324400 @default.
• W3040914718 cites W2159391376 @default.
• W3040914718 cites W2286779287 @default.
• W3040914718 cites W2555516405 @default.
• W3040914718 cites W2735256993 @default.
• W3040914718 cites W2746804366 @default.
• W3040914718 cites W2751041826 @default.
• W3040914718 cites W2801858894 @default.
• W3040914718 cites W2806295244 @default.
• W3040914718 cites W2891566871 @default.
• W3040914718 cites W2914596603 @default.
• W3040914718 cites W2967901922 @default.
• W3040914718 cites W2995276697 @default.
• W3040914718 cites W4205407119 @default.
• W3040914718 cites W4293247451 @default.
• W3040914718 cites W769835730 @default.
• W3040914718 doi "https://doi.org/10.1016/j.chemosphere.2020.127556" @default.
• W3040914718 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32682134" @default.
• W3040914718 hasPublicationYear "2020" @default.
• W3040914718 type Work @default.
• W3040914718 sameAs 3040914718 @default.
• W3040914718 citedByCount "6" @default.
• W3040914718 countsByYear W30409147182021 @default.
• W3040914718 countsByYear W30409147182022 @default.
• W3040914718 countsByYear W30409147182023 @default.
• W3040914718 crossrefType "journal-article" @default.
• W3040914718 hasAuthorship W3040914718A5005276291 @default.
• W3040914718 hasAuthorship W3040914718A5009378794 @default.
• W3040914718 hasAuthorship W3040914718A5019787655 @default.
• W3040914718 hasAuthorship W3040914718A5021043590 @default.
• W3040914718 hasAuthorship W3040914718A5033000817 @default.
• W3040914718 hasAuthorship W3040914718A5038089792 @default.
• W3040914718 hasAuthorship W3040914718A5043399981 @default.
• W3040914718 hasAuthorship W3040914718A5050606570 @default.
• W3040914718 hasAuthorship W3040914718A5059817117 @default.
• W3040914718 hasAuthorship W3040914718A5091880685 @default.
• W3040914718 hasConcept C126322002 @default.
• W3040914718 hasConcept C150903083 @default.
• W3040914718 hasConcept C16685009 @default.
• W3040914718 hasConcept C178790620 @default.
• W3040914718 hasConcept C185592680 @default.
• W3040914718 hasConcept C203014093 @default.
• W3040914718 hasConcept C207001950 @default.
• W3040914718 hasConcept C2777658100 @default.
• W3040914718 hasConcept C2780091579 @default.
• W3040914718 hasConcept C2780990795 @default.
• W3040914718 hasConcept C29730261 @default.
• W3040914718 hasConcept C502942594 @default.
• W3040914718 hasConcept C71924100 @default.
• W3040914718 hasConcept C82685317 @default.
• W3040914718 hasConcept C86803240 @default.
• W3040914718 hasConcept C98274493 @default.
• W3040914718 hasConceptScore W3040914718C126322002 @default.
• W3040914718 hasConceptScore W3040914718C150903083 @default.
• W3040914718 hasConceptScore W3040914718C16685009 @default.

• next