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• W3040919076 abstract "Abstract Background Possible variation in bronchodilator response (BDR) according to age at the diagnosis of adult-onset asthma is unknown. Our aim was to assess if BDR in FEV 1 is related to age at diagnosis of adult-onset asthma and how many subjects fulfill the 400 mL criterion of BDR, the suggested cut-off for asthma-like reversibility in asthma-COPD overlap (ACO). Methods A total of 1030 patients with adult-onset asthma were included; 245 from SAAS (Seinäjoki Adult Asthma Study, Finland) and 785 from COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) cohorts. BDR in FEV 1 at the diagnosis of asthma was assessed. Patients were divided into groups based on age at asthma diagnosis: < 40, 40–59.9, and ≥ 60 years. The cohorts were analyzed separately. Results BDR % in FEV 1 did not differ between the groups of different age at asthma diagnosis and no correlation between BDR and age was found. Of patients aged ≥40 years, only 18% (SAAS-cohort) and 5% (COREA-cohort) reached the 400 mL BDR in FEV 1 . After exclusion of possible ACO patients, the results remained similar. Conclusion By using two large cohorts of steroid-naive patients with asthma, we have shown that BDR at diagnosis of asthma is constant over large age span range, and the limit of 400 mL in BDR in FEV 1 is rarely reached. Trial registration Seinäjoki Adult Asthma Study is registered at ClinicalTrials.gov with identifier number NCT02733016 ." @default.
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• W3040919076 date "2020-07-13" @default.
• W3040919076 modified "2023-10-18" @default.
• W3040919076 title "Relationship between age and bronchodilator response at diagnosis in adult-onset asthma" @default.
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• W3040919076 doi "https://doi.org/10.1186/s12931-020-01441-w" @default.
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