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• W3040929984 abstract "Current theory suggests that treatment-resistant depression (TRD) involves impaired neuroplasticity resulting in cognitive and neural rigidity, and that clinical improvement may require increasing brain flexibility and adaptability.In this hypothesis-generating study, we sought to identify preliminary evidence of brain flexibility correlates of clinical change within the context of an open-label ketamine trial in adolescents with TRD, focusing on two promising candidate markers of neural flexibility: (a) entropy of resting-state functional magnetic resonance imaging (fMRI) signals; and (b) insulin-stimulated phosphorylation of mammalian target of rapamycin (mTOR) and glycogen synthase-3-beta (GSK3β) in peripheral blood mononuclear cells.We collected resting-state functional magnetic resonance imaging data and blood samples from 13 adolescents with TRD before and after a series of six ketamine infusions over 2 weeks. Usable pre/post ketamine data were available from 11 adolescents for imaging and from 10 adolescents for molecular signaling. We examined correlations between treatment response and changes in the central and peripheral flexibility markers.Depression reduction correlated with increased nucleus accumbens entropy. Follow-up analyses suggested that physiological changes were associated with treatment response. In contrast to treatment non-responders (n=6), responders (n=5) showed greater increase in nucleus accumbens entropy after ketamine, together with greater post-treatment insulin/mTOR/GSK3β signaling.These data provide preliminary evidence that changes in neural flexibility may underlie symptom relief in adolescents with TRD following ketamine. Future research with adequately powered samples is needed to confirm resting-state entropy and insulin-stimulated mTOR and GSK3β as brain flexibility markers and candidate targets for future clinical trials.Ketamine in adolescents with treatment-resistant depressionURL: https://clinicaltrials.gov/ct2/show/NCT02078817Registration number: NCT02078817." @default.
• W3040929984 created "2020-07-16" @default.
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• W3040929984 date "2020-07-09" @default.
• W3040929984 modified "2023-10-18" @default.
• W3040929984 title "Brain entropy and neurotrophic molecular markers accompanying clinical improvement after ketamine: Preliminary evidence in adolescents with treatment-resistant depression" @default.
• W3040929984 cites W171724531 @default.
• W3040929984 cites W1963525383 @default.
• W3040929984 cites W1969644317 @default.
• W3040929984 cites W1973676387 @default.
• W3040929984 cites W1983183519 @default.
• W3040929984 cites W1983302342 @default.
• W3040929984 cites W1983617759 @default.
• W3040929984 cites W1984615306 @default.
• W3040929984 cites W1990134753 @default.
• W3040929984 cites W1997894884 @default.
• W3040929984 cites W2001307591 @default.
• W3040929984 cites W2010687070 @default.
• W3040929984 cites W2013336473 @default.
• W3040929984 cites W2017923649 @default.
• W3040929984 cites W2018920598 @default.
• W3040929984 cites W2020906215 @default.
• W3040929984 cites W2037096268 @default.
• W3040929984 cites W2040073285 @default.
• W3040929984 cites W2047931034 @default.
• W3040929984 cites W2051187163 @default.
• W3040929984 cites W2055862036 @default.
• W3040929984 cites W2063835360 @default.
• W3040929984 cites W2067121720 @default.
• W3040929984 cites W2067963436 @default.
• W3040929984 cites W2071881327 @default.
• W3040929984 cites W2072810539 @default.
• W3040929984 cites W2073259618 @default.
• W3040929984 cites W2078280300 @default.
• W3040929984 cites W2080744486 @default.
• W3040929984 cites W2088599339 @default.
• W3040929984 cites W2089351762 @default.
• W3040929984 cites W2090357978 @default.
• W3040929984 cites W2095438393 @default.
• W3040929984 cites W2098750661 @default.
• W3040929984 cites W2100036649 @default.
• W3040929984 cites W2101356492 @default.
• W3040929984 cites W2104811988 @default.
• W3040929984 cites W2105824687 @default.
• W3040929984 cites W2106636235 @default.
• W3040929984 cites W2109543774 @default.
• W3040929984 cites W2111728433 @default.
• W3040929984 cites W2113423210 @default.
• W3040929984 cites W2114809469 @default.
• W3040929984 cites W2117621792 @default.
• W3040929984 cites W2118826874 @default.
• W3040929984 cites W2143463042 @default.
• W3040929984 cites W2148726987 @default.
• W3040929984 cites W2152292563 @default.
• W3040929984 cites W2156447271 @default.
• W3040929984 cites W2280212519 @default.
• W3040929984 cites W2337400527 @default.
• W3040929984 cites W2529625357 @default.
• W3040929984 cites W2589179208 @default.
• W3040929984 cites W2592351868 @default.
• W3040929984 cites W2605399484 @default.
• W3040929984 cites W2755167598 @default.
• W3040929984 cites W2762798648 @default.
• W3040929984 cites W2770346924 @default.
• W3040929984 cites W2777987555 @default.
• W3040929984 cites W2785432401 @default.
• W3040929984 cites W2793484468 @default.
• W3040929984 cites W2797697710 @default.
• W3040929984 cites W2801747013 @default.
• W3040929984 cites W2802275219 @default.
• W3040929984 cites W2804644885 @default.
• W3040929984 cites W2884469025 @default.
• W3040929984 cites W2895232125 @default.
• W3040929984 cites W2912867888 @default.
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• W3040929984 cites W2968777126 @default.
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• W3040929984 doi "https://doi.org/10.1177/0269881120928203" @default.
• W3040929984 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8569740" @default.
• W3040929984 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32643995" @default.
• W3040929984 hasPublicationYear "2020" @default.
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