FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040948319> ?p ?o ?g. }

• W3040948319 abstract "Ingestion of food- or waterborne antibiotic-resistant bacteria may lead to the dissemination of antibiotic-resistance genes in the gut microbiota and the development of antibiotic-resistant bacterial infection, a significant threat to animal and public health. Food or water may be contaminated with multiple resistant bacteria, but animal models on gene transfer were mainly based on single-strain infections. In this study, we investigated the mobility of β-lactam resistance following infection with single- versus multi-strain of resistant bacteria under ampicillin treatment. We characterized three bacterial strains isolated from food-animal production systems, Escherichia coli O80:H26 and Salmonella enterica serovars Bredeney and Heidelberg. Each strain carries at least one conjugative plasmid that encodes a β-lactamase. We orally infected mice with each or all three bacterial strain(s) in the presence or absence of ampicillin treatment. We assessed plasmid transfer from the three donor bacteria to an introduced E. coli CV601gfp recipient in the mouse gut, and evaluated the impacts of the bacterial infection on gut microbiota and gut health. In the absence of ampicillin treatment, none of the donor or recipient bacteria established in the normal gut microbiota and plasmid transfer was not detected. In contrast, the ampicillin treatment disrupted the gut microbiota and enabled S. Bredeney and Heidelberg to colonize and transfer their plasmids to the E. coli CV601gfp recipient. E. coli O80:H26 on its own failed to colonize the mouse gut. However, during co-infection with the two Salmonella strains, E. coli O80:H26 colonized and transferred its plasmid to the E. coli CV601gfp recipient and a residential E. coli O2:H6 strain. The co-infection significantly increased plasmid transfer frequency, enhanced Proteobacteria expansion and resulted in inflammation in the mouse gut. Our findings suggest that single-strain infection models for evaluating in vivo gene transfer may underrepresent the consequences of multi-strain infections following the consumption of heavily contaminated food or water." @default.
• W3040948319 created "2020-07-16" @default.
• W3040948319 creator A5003009699 @default.
• W3040948319 creator A5003087172 @default.
• W3040948319 creator A5003437544 @default.
• W3040948319 creator A5004675827 @default.
• W3040948319 creator A5007489172 @default.
• W3040948319 creator A5025131528 @default.
• W3040948319 creator A5031228946 @default.
• W3040948319 creator A5035117260 @default.
• W3040948319 creator A5037798225 @default.
• W3040948319 creator A5038985005 @default.
• W3040948319 creator A5043689231 @default.
• W3040948319 creator A5044682771 @default.
• W3040948319 creator A5049095430 @default.
• W3040948319 creator A5050534790 @default.
• W3040948319 creator A5051278398 @default.
• W3040948319 creator A5069038894 @default.
• W3040948319 date "2020-07-07" @default.
• W3040948319 modified "2023-10-16" @default.
• W3040948319 title "Mobility of β-Lactam Resistance Under Bacterial Co-infection and Ampicillin Treatment in a Mouse Model" @default.
• W3040948319 cites W1608285835 @default.
• W3040948319 cites W1963871485 @default.
• W3040948319 cites W1966223820 @default.
• W3040948319 cites W1982479612 @default.
• W3040948319 cites W1993830991 @default.
• W3040948319 cites W1999699598 @default.
• W3040948319 cites W2032347305 @default.
• W3040948319 cites W2032782331 @default.
• W3040948319 cites W2051619765 @default.
• W3040948319 cites W2063107371 @default.
• W3040948319 cites W2064077946 @default.
• W3040948319 cites W2096093282 @default.
• W3040948319 cites W2098466396 @default.
• W3040948319 cites W2099176808 @default.
• W3040948319 cites W2108638835 @default.
• W3040948319 cites W2113532719 @default.
• W3040948319 cites W2115701239 @default.
• W3040948319 cites W2117235103 @default.
• W3040948319 cites W2129917444 @default.
• W3040948319 cites W2134519766 @default.
• W3040948319 cites W2134893590 @default.
• W3040948319 cites W2140353364 @default.
• W3040948319 cites W2147692019 @default.
• W3040948319 cites W2152127318 @default.
• W3040948319 cites W2154017836 @default.
• W3040948319 cites W2160452746 @default.
• W3040948319 cites W2160555071 @default.
• W3040948319 cites W2164030271 @default.
• W3040948319 cites W2165853813 @default.
• W3040948319 cites W2168056522 @default.
• W3040948319 cites W2168156515 @default.
• W3040948319 cites W2207760002 @default.
• W3040948319 cites W2319515304 @default.
• W3040948319 cites W2515781381 @default.
• W3040948319 cites W2517497469 @default.
• W3040948319 cites W2611882427 @default.
• W3040948319 cites W2626417943 @default.
• W3040948319 cites W2768892520 @default.
• W3040948319 cites W2791729250 @default.
• W3040948319 cites W2794623497 @default.
• W3040948319 cites W2800561326 @default.
• W3040948319 cites W2883838322 @default.
• W3040948319 cites W2888365760 @default.
• W3040948319 cites W2923307408 @default.
• W3040948319 cites W2946594166 @default.
• W3040948319 cites W2946980189 @default.
• W3040948319 cites W2951093118 @default.
• W3040948319 cites W2952167528 @default.
• W3040948319 cites W4242789727 @default.
• W3040948319 cites W7012447 @default.
• W3040948319 doi "https://doi.org/10.3389/fmicb.2020.01591" @default.
• W3040948319 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7358583" @default.
• W3040948319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32733428" @default.
• W3040948319 hasPublicationYear "2020" @default.
• W3040948319 type Work @default.
• W3040948319 sameAs 3040948319 @default.
• W3040948319 citedByCount "5" @default.
• W3040948319 countsByYear W30409483192021 @default.
• W3040948319 countsByYear W30409483192022 @default.
• W3040948319 countsByYear W30409483192023 @default.
• W3040948319 crossrefType "journal-article" @default.
• W3040948319 hasAuthorship W3040948319A5003009699 @default.
• W3040948319 hasAuthorship W3040948319A5003087172 @default.
• W3040948319 hasAuthorship W3040948319A5003437544 @default.
• W3040948319 hasAuthorship W3040948319A5004675827 @default.
• W3040948319 hasAuthorship W3040948319A5007489172 @default.
• W3040948319 hasAuthorship W3040948319A5025131528 @default.
• W3040948319 hasAuthorship W3040948319A5031228946 @default.
• W3040948319 hasAuthorship W3040948319A5035117260 @default.
• W3040948319 hasAuthorship W3040948319A5037798225 @default.
• W3040948319 hasAuthorship W3040948319A5038985005 @default.
• W3040948319 hasAuthorship W3040948319A5043689231 @default.
• W3040948319 hasAuthorship W3040948319A5044682771 @default.
• W3040948319 hasAuthorship W3040948319A5049095430 @default.
• W3040948319 hasAuthorship W3040948319A5050534790 @default.
• W3040948319 hasAuthorship W3040948319A5051278398 @default.
• W3040948319 hasAuthorship W3040948319A5069038894 @default.
• W3040948319 hasBestOaLocation W30409483191 @default.
• W3040948319 hasConcept C104317684 @default.

• next