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- W3040965854 abstract "A 49-year-old man with chronic hepatitis B and resected 14-cm hepatocellular carcinoma (HCC) presented with a rapidly enlarging exophytic upper palate lesion, 4 months postsurgery (Figure A). It displaced his frontal teeth, causing pain, bleeding, and difficulty with oral intake. Computed tomography of the facial bones demonstrated a 3.3 × 2.9 × 2.7 cm erosive soft tissue density (Figure B). Excisional biopsy initially suggested a pyogenic granuloma; however, immunostaining was positive for Hep Par-1 and polyclonal carcinoembryonic antigen in canalicular pattern, confirming metastatic HCC (Figure C). The lesion initially responded to radiation therapy (Figure D); however, it eventually progressed despite further radiation, lenvatinib, and immunotherapy. He subsequently developed lung and brain metastases, and passed away 1 year later. Oral metastases are rare, accounting for 1%–3% of all oral neoplasms. This occurs through the hematogenous route, or via Batson plexus. An oral lesion may be the first sign of malignancy, and clinicians should consider HCC if the patient has a background of viral hepatitis or cirrhosis. HCC with oral metastasis has a poor prognosis, hence alleviating symptoms is vital to maintaining quality of life, and adequate oral function. Treatment options are palliative, including systemic therapy, radiation, and best supportive care." @default.
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- W3040965854 date "2020-07-01" @default.
- W3040965854 modified "2023-09-25" @default.
- W3040965854 title "An Unusual Extrahepatic Hepatocellular Carcinoma" @default.
- W3040965854 doi "https://doi.org/10.1016/j.cgh.2020.07.010" @default.
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