Matches in SemOpenAlex for { <https://semopenalex.org/work/W3040981623> ?p ?o ?g. }
- W3040981623 endingPage "32" @default.
- W3040981623 startingPage "32" @default.
- W3040981623 abstract "Therapeutic anti-HER2 antibodies and antibody–drug conjugates (ADCs) have undoubtedly benefitted patients. Nonetheless, patients ultimately relapse—some sooner than others. Currently approved anti-HER2 drugs are expensive and their cost-effectiveness is debated. There is increased awareness that internalization and lysosomal processing including subsequent payload intracellular accumulation and retention for ADCs are critical therapeutic attributes. Although HER2 preferential overexpression on the surface of tumor cells is attractive, its poor internalization and trafficking to lysosomes has been linked to poor therapeutic outcomes. To help address such issues, this review will comprehensively detail the most relevant findings on internalization and cellular accumulation for approved and investigational anti-HER2 antibodies and ADCs. The improved clarity of the HER2 system could improve antibody and ADC designs and approaches for next-generation anti-HER2 and other receptor targeting agents." @default.
- W3040981623 created "2020-07-16" @default.
- W3040981623 creator A5031022558 @default.
- W3040981623 date "2020-07-13" @default.
- W3040981623 modified "2023-10-18" @default.
- W3040981623 title "Improving Receptor-Mediated Intracellular Access and Accumulation of Antibody Therapeutics—The Tale of HER2" @default.
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