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- W3040983516 abstract "A number of novel drugs targeting the fibroblast growth factor receptor (FGFR) signaling pathway have been developed, including mostly tyrosine kinase inhibitors, selective inhibitors or monoclonal antibodies. Multiple preclinical and clinical studies have been conducted worldwide to ascertain their effects on diverse solid tumors. Drugs, such as lenvatinib, dovitinib and other non‑specific FGFR inhibitors, widely used in clinical practice, have been approved by the Food and Drug Administration for cancer therapy, although the majority of drugs remain in preclinical tests or clinical research. The resistance to a single agent for FGFR inhibition with synthetic lethal action may be overcome by a combination of therapeutic approaches and FGFR inhibitors, which could also enhance the sensitivity to other therapeutics. Therefore, the aim of the present review is to describe the pharmacological characteristics of FGFR inhibitors that may be combined with other therapeutic agents and the preclinical data supporting their combination. Additionally, their clinical implications and the remaining challenges for FGFR inhibitor combination regimens are discussed." @default.
- W3040983516 created "2020-07-16" @default.
- W3040983516 creator A5002840745 @default.
- W3040983516 creator A5011125335 @default.
- W3040983516 creator A5021221579 @default.
- W3040983516 creator A5021602427 @default.
- W3040983516 creator A5035701638 @default.
- W3040983516 creator A5044089988 @default.
- W3040983516 creator A5054400065 @default.
- W3040983516 creator A5056036725 @default.
- W3040983516 date "2020-07-10" @default.
- W3040983516 modified "2023-10-17" @default.
- W3040983516 title "Therapeutic implications of fibroblast growth factor receptor inhibitors in a combination regimen for solid tumors (Review)" @default.
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