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• W3040984737 abstract "Overexpression of human epidermal growth factor receptor 2 (HER2) has been reported in glioblastoma as well as breast, gastric, lung, colorectal, and pancreatic cancers. Its expression is associated with poor clinical outcomes. Anti-HER2 antibodies have provided significant survival benefits to patients with HER2-overexpressing breast and gastric cancers. We recently developed an anti-HER2 monoclonal antibody (mAb), H2Mab-19 (IgG2b, kappa), by immunizing mice with the extracellular domain of HER2, which is expressed in LN229 glioblastoma cells. In this study, we investigated the antitumor activity of H2Mab-19 in an LN229 glioblastoma xenograft model. H2Mab-19 showed high binding affinity (KD: 1.1 × 10−8 M) against LN229 cells. Furthermore, H2Mab-19 significantly reduced tumor development in an LN229 xenograft. These results suggest that treatment with H2Mab-19 may be a useful therapy for patients with HER2-expressing glioblastomas." @default.
• W3040984737 created "2020-07-16" @default.
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• W3040984737 date "2020-08-01" @default.
• W3040984737 modified "2023-09-23" @default.
• W3040984737 title "An Antihuman Epidermal Growth Factor Receptor 2 Monoclonal Antibody (H₂Mab-19) Exerts Antitumor Activity in Glioblastoma Xenograft Models" @default.
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• W3040984737 doi "https://doi.org/10.1089/mab.2020.0013" @default.
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