FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041001978> ?p ?o ?g. }

• W3041001978 endingPage "1879" @default.
• W3041001978 startingPage "1879" @default.
• W3041001978 abstract "Epidemiologic studies have shown that vast majority of lung cancers (85–90%) are causally linked to tobacco smoking. Although much information has been gained about the effects of smoking on various signaling pathways, little is known about how deregulation of miRNAs leads to activation of oncogenes and inhibition of tumor suppressor genes in non-small cell lung cancer (NSCLC). Our previous study showed that smoking inhibits TGF-β-induced tumor suppressor functions through downregulation of Smad3 in lung cancer cells. In order to understand the upstream mechanism of downregulation of Smad3 by smoking, we performed miRNA microarray analyses after treating human lung adenocarcinoma A549 and immortalized peripheral lung epithelial HPL1A cells with cigarette smoke condensate (CSC). We identified miR-216b as being upregulated in CSC treated cells. MiR-216b overexpression decreases Smad3 protein expression by binding to its 3′-UTR, and attenuates transforming growth factor beta (TGF-β) signaling and target gene expression. MiR-216b increases B-cell lymphoma 2 (BCL-2) expression and promotes chemoresistance of NSCLC cells by decreasing apoptosis. Increased acetylation of histones H3 and H4 in miR-216b gene promoter plays a role in CSC induced miR-216b expression. Taken together, these results suggest that smoking-mediated upregulation of miR-216b increases NSCLC cell growth by downregulating Smad3 and inhibiting TGF-β-induced tumor suppressor function, and induces resistance to platinum-based therapy." @default.
• W3041001978 created "2020-07-16" @default.
• W3041001978 creator A5013835810 @default.
• W3041001978 creator A5019676060 @default.
• W3041001978 creator A5047037927 @default.
• W3041001978 date "2020-07-13" @default.
• W3041001978 modified "2023-09-25" @default.
• W3041001978 title "MiR-216b/Smad3/BCL-2 Axis Is Involved in Smoking-Mediated Drug Resistance in Non-Small Cell Lung Cancer" @default.
• W3041001978 cites W1899174622 @default.
• W3041001978 cites W1945014698 @default.
• W3041001978 cites W1969721873 @default.
• W3041001978 cites W1977004529 @default.
• W3041001978 cites W1993534135 @default.
• W3041001978 cites W1995624011 @default.
• W3041001978 cites W1999792045 @default.
• W3041001978 cites W2014946489 @default.
• W3041001978 cites W2017986614 @default.
• W3041001978 cites W2018146396 @default.
• W3041001978 cites W2024016490 @default.
• W3041001978 cites W2039797050 @default.
• W3041001978 cites W2043076602 @default.
• W3041001978 cites W2043635888 @default.
• W3041001978 cites W2047218894 @default.
• W3041001978 cites W2064689265 @default.
• W3041001978 cites W2070777085 @default.
• W3041001978 cites W2072331122 @default.
• W3041001978 cites W2075201743 @default.
• W3041001978 cites W2082557336 @default.
• W3041001978 cites W2083832226 @default.
• W3041001978 cites W2084242910 @default.
• W3041001978 cites W2086608137 @default.
• W3041001978 cites W2106286289 @default.
• W3041001978 cites W2116845070 @default.
• W3041001978 cites W2117864836 @default.
• W3041001978 cites W2118686454 @default.
• W3041001978 cites W2119363473 @default.
• W3041001978 cites W2119779058 @default.
• W3041001978 cites W2132997519 @default.
• W3041001978 cites W2136280424 @default.
• W3041001978 cites W2144971212 @default.
• W3041001978 cites W2147131744 @default.
• W3041001978 cites W2148575470 @default.
• W3041001978 cites W2155954232 @default.
• W3041001978 cites W2159864284 @default.
• W3041001978 cites W2162674813 @default.
• W3041001978 cites W2163674184 @default.
• W3041001978 cites W2614986188 @default.
• W3041001978 cites W2763057023 @default.
• W3041001978 cites W2990440648 @default.
• W3041001978 cites W2999417355 @default.
• W3041001978 cites W3003526695 @default.
• W3041001978 doi "https://doi.org/10.3390/cancers12071879" @default.
• W3041001978 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408725" @default.
• W3041001978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32668597" @default.
• W3041001978 hasPublicationYear "2020" @default.
• W3041001978 type Work @default.
• W3041001978 sameAs 3041001978 @default.
• W3041001978 citedByCount "7" @default.
• W3041001978 countsByYear W30410019782020 @default.
• W3041001978 countsByYear W30410019782021 @default.
• W3041001978 countsByYear W30410019782022 @default.
• W3041001978 countsByYear W30410019782023 @default.
• W3041001978 crossrefType "journal-article" @default.
• W3041001978 hasAuthorship W3041001978A5013835810 @default.
• W3041001978 hasAuthorship W3041001978A5019676060 @default.
• W3041001978 hasAuthorship W3041001978A5047037927 @default.
• W3041001978 hasBestOaLocation W30410019781 @default.
• W3041001978 hasConcept C104317684 @default.
• W3041001978 hasConcept C121608353 @default.
• W3041001978 hasConcept C126322002 @default.
• W3041001978 hasConcept C127561419 @default.
• W3041001978 hasConcept C142724271 @default.
• W3041001978 hasConcept C145059251 @default.
• W3041001978 hasConcept C2776256026 @default.
• W3041001978 hasConcept C2781182431 @default.
• W3041001978 hasConcept C502942594 @default.
• W3041001978 hasConcept C55493867 @default.
• W3041001978 hasConcept C71924100 @default.
• W3041001978 hasConcept C86803240 @default.
• W3041001978 hasConceptScore W3041001978C104317684 @default.
• W3041001978 hasConceptScore W3041001978C121608353 @default.
• W3041001978 hasConceptScore W3041001978C126322002 @default.
• W3041001978 hasConceptScore W3041001978C127561419 @default.
• W3041001978 hasConceptScore W3041001978C142724271 @default.
• W3041001978 hasConceptScore W3041001978C145059251 @default.
• W3041001978 hasConceptScore W3041001978C2776256026 @default.
• W3041001978 hasConceptScore W3041001978C2781182431 @default.
• W3041001978 hasConceptScore W3041001978C502942594 @default.
• W3041001978 hasConceptScore W3041001978C55493867 @default.
• W3041001978 hasConceptScore W3041001978C71924100 @default.
• W3041001978 hasConceptScore W3041001978C86803240 @default.
• W3041001978 hasIssue "7" @default.
• W3041001978 hasLocation W30410019781 @default.
• W3041001978 hasLocation W30410019782 @default.
• W3041001978 hasLocation W30410019783 @default.
• W3041001978 hasOpenAccess W3041001978 @default.
• W3041001978 hasPrimaryLocation W30410019781 @default.
• W3041001978 hasRelatedWork W2121354878 @default.

• next