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• W3041022014 abstract "Neurotrophic corneal ulcers are difficult to treat and the conventional treatment often results in failure. A new matrix regenerative agent (“ReGeneraTing Agents”, RGTA), Cacicol® (Laboratoires Théa), has demonstrated good results over the last years. Therefore, the aim of this study was to evaluate the response to Cacicol® in a series of cases with corneal ulcers neurotrophic. Retrospective case series. 11 patients with corneal ulcers unresponsive to conventional therapy underwent treatment with Cacicol®. One cycle included 1 drop every two days for 5 days. The range of conventional therapy prior to Cacicol® was 0–91 days. Upon introducing Cacicol® 82% (9/11) of the cases were cured and 18% (2/11) failed requiring an amniotic membrane transplant or penetrating keratoplasty. 67% (6/9) of the patients who had experienced healing required only one cycle of Cacicol®. 45% (5/11) patients needed more than one cycle of Cacicol®. One corneal bacterial ulcer responded favorably and one case related to Acanthamoeba failed. Most of the patients improved or maintained their visual acuity. Cacicol® was a useful therapy in a high number of difficult neurotrophic corneal ulcers, including corneal infections. Some cases may require more than one cycle of Cacicol® or its immediate use to achieve the desired result. Las úlceras corneales neurotróficas son difíciles de tratar y las terapias convencionales fracasan con frecuencia. Un nuevo agente regenerativo de la matriz extracelular (“ReGeneraTing Agents”, RGTA), Cacicol® (Laboratoires Théa), ha demostrado buenos resultados en los últimos años. El objetivo de este estudio fue evaluar la respuesta a Cacicol® en una serie de casos con úlceras corneales neurotróficas. Serie de casos retrospectiva. 11 pacientes con úlceras corneales neurotróficas que no respondieron a una terapia convencional fueron tratados con Cacicol®. Un ciclo incluyó 1 gota cada 2 días durante 5 días. El rango de duración de la terapia convencional, previa al comienzo del tratamiento con Cacicol®, fue 0 a 91 días. Tras introducir Cacicol® el 82% (9/11) de los casos se curaron y el 18% (2/11) no lo hicieron, llegando a requerir un trasplante de membrana amniótica o una queratoplastia penetrante, respectivamente. El 67% (6/9) de los pacientes curados requirieron solo un ciclo de Cacicol® y el 45% (5/11) pacientes necesitaron más de un ciclo. Un caso de úlcera corneal bacteriana respondió favorablemente pero un caso infectado por Acamthamoeba fracasó. En la mayoría de los pacientes, la agudeza visual mejoró o se mantuvo. Cacicol® resultó una terapia exitosa en una alta proporción de úlceras neurotróficas, incluidas las infecciosas. Algunos casosrequieren más de un ciclo de Cacicol® o su uso como primer línea de tratamiento." @default.
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• W3041022014 date "2020-09-01" @default.
• W3041022014 modified "2023-10-18" @default.
• W3041022014 title "Management of corneal neurotrophic ulcers with Cacicol®-RGTA (ReGeneraTing Agent): a case series" @default.
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• W3041022014 doi "https://doi.org/10.1016/j.oftale.2020.04.005" @default.
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