Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041024760> ?p ?o ?g. }
- W3041024760 endingPage "614" @default.
- W3041024760 startingPage "599" @default.
- W3041024760 abstract "Neural stem cells (NSCs) can generate new neurons to repair brain injury and central nervous system disease by promoting neural regeneration. MicroRNAs (miRNAs) involve in neural development, brain damage, and neurological diseases repair. Recent reports show that several miRNAs express in NSCs and are important to neurogenesis. Neurites play a key role in NSC-related neurogenesis. However, the mechanism of NSC neurite generation is rarely studied. We surprisingly noticed that the neurites increased after bone morphogenetic protein (BMP) treatment in rat NSCs. This process was accompanied by the dynamic change of miRNA-29. Then we discovered that miR-29a regulated neural neurites in rat hippocampus NSCs. Overexpression of miR-29a reduced the cell soma area and promoted the neurite outgrowth of NSCs. Cell soma area became small, whereas the number of neurite increased. Moreover, neurite complexity increased dramatically, with more primary and secondary branches after miR-29a overexpression. In addition, miR-29a overexpression still maintained the stemness of NSCs. Besides, we identified that miR-29a can promote the neurite outgrowth by targeting extracellular matrix-related genes like Fibrillin 1 (Fbn1), Follistatin-like 1 (Fstl1), and laminin subunit gamma 2 (Lamc2). These findings may provide a novel role of miR-29a to regulate neurite outgrowth and development of NSCs. We also offered a possible theoretical basis to the migration mechanism of NSCs in brain development and damage repair." @default.
- W3041024760 created "2020-07-16" @default.
- W3041024760 creator A5006469973 @default.
- W3041024760 creator A5015102287 @default.
- W3041024760 creator A5020430386 @default.
- W3041024760 creator A5020738242 @default.
- W3041024760 creator A5026567475 @default.
- W3041024760 creator A5028555994 @default.
- W3041024760 creator A5031939400 @default.
- W3041024760 creator A5032750577 @default.
- W3041024760 creator A5035551158 @default.
- W3041024760 creator A5037069151 @default.
- W3041024760 creator A5040829339 @default.
- W3041024760 creator A5058055982 @default.
- W3041024760 creator A5078092925 @default.
- W3041024760 creator A5087446215 @default.
- W3041024760 creator A5089000611 @default.
- W3041024760 date "2020-05-01" @default.
- W3041024760 modified "2023-10-15" @default.
- W3041024760 title "miR-29a Promotes the Neurite Outgrowth of Rat Neural Stem Cells by Targeting Extracellular Matrix to Repair Brain Injury" @default.
- W3041024760 cites W144423133 @default.
- W3041024760 cites W1503727145 @default.
- W3041024760 cites W1563316806 @default.
- W3041024760 cites W1909663747 @default.
- W3041024760 cites W1963820950 @default.
- W3041024760 cites W1975998453 @default.
- W3041024760 cites W1985498551 @default.
- W3041024760 cites W1995924726 @default.
- W3041024760 cites W1997624559 @default.
- W3041024760 cites W1999574084 @default.
- W3041024760 cites W2000418014 @default.
- W3041024760 cites W2014946489 @default.
- W3041024760 cites W2024997276 @default.
- W3041024760 cites W2025902983 @default.
- W3041024760 cites W2032702875 @default.
- W3041024760 cites W2035106298 @default.
- W3041024760 cites W2036470943 @default.
- W3041024760 cites W2046157151 @default.
- W3041024760 cites W2048794781 @default.
- W3041024760 cites W2059935149 @default.
- W3041024760 cites W2068298721 @default.
- W3041024760 cites W2077630079 @default.
- W3041024760 cites W2084652820 @default.
- W3041024760 cites W2088005129 @default.
- W3041024760 cites W2088405783 @default.
- W3041024760 cites W2092758369 @default.
- W3041024760 cites W2094357849 @default.
- W3041024760 cites W2099022510 @default.
- W3041024760 cites W2102278945 @default.
- W3041024760 cites W2103177465 @default.
- W3041024760 cites W2108319506 @default.
- W3041024760 cites W2120055234 @default.
- W3041024760 cites W2126436396 @default.
- W3041024760 cites W2131282078 @default.
- W3041024760 cites W2135518234 @default.
- W3041024760 cites W2136863003 @default.
- W3041024760 cites W2137247854 @default.
- W3041024760 cites W2143470156 @default.
- W3041024760 cites W2146104000 @default.
- W3041024760 cites W2149146453 @default.
- W3041024760 cites W2152284832 @default.
- W3041024760 cites W2155290141 @default.
- W3041024760 cites W2157868064 @default.
- W3041024760 cites W2158482287 @default.
- W3041024760 cites W2160390633 @default.
- W3041024760 cites W2162983737 @default.
- W3041024760 cites W2169034821 @default.
- W3041024760 cites W2169754078 @default.
- W3041024760 cites W2170551349 @default.
- W3041024760 cites W2172270516 @default.
- W3041024760 cites W2187985754 @default.
- W3041024760 cites W2188517806 @default.
- W3041024760 cites W2319254066 @default.
- W3041024760 cites W2547225283 @default.
- W3041024760 cites W2576977194 @default.
- W3041024760 cites W2580496556 @default.
- W3041024760 cites W2597736860 @default.
- W3041024760 cites W2732147874 @default.
- W3041024760 cites W2756139356 @default.
- W3041024760 cites W2770383780 @default.
- W3041024760 cites W2770989231 @default.
- W3041024760 cites W2799538301 @default.
- W3041024760 cites W2808361199 @default.
- W3041024760 cites W2885519415 @default.
- W3041024760 cites W2910931852 @default.
- W3041024760 cites W4212820007 @default.
- W3041024760 cites W571974440 @default.
- W3041024760 doi "https://doi.org/10.1089/scd.2019.0174" @default.
- W3041024760 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31885334" @default.
- W3041024760 hasPublicationYear "2020" @default.
- W3041024760 type Work @default.
- W3041024760 sameAs 3041024760 @default.
- W3041024760 citedByCount "22" @default.
- W3041024760 countsByYear W30410247602020 @default.
- W3041024760 countsByYear W30410247602021 @default.
- W3041024760 countsByYear W30410247602022 @default.
- W3041024760 countsByYear W30410247602023 @default.
- W3041024760 crossrefType "journal-article" @default.