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- W3041041105 abstract "Abstract Background Low-risk HPV infection has not been the subject of epigenetic investigation. The present study was carried out in order to investigate the methylation status of CpG sites in non-genital cutaneous warts. Methods Genomic DNA was extracted from 24 paired epidermal samples of warts and normal skin. DNA samples were bisulfite converted and underwent genome-wide methylation profiling using the Infinium MethylationEPIC BeadChip Kit. Results From a total of 844,234 CpG sites, 56,960 and 43,040 CpG sites were found to be hypo- and hypermethylated, respectively, in non-genital cutaneous warts. The most differentially methylated CpG sites in warts were located within the C10orf26 , FAM83H-AS1 , ZNF644 , LINC00702 , GSAP , STAT5A , HDAC4 , NCALD , and EXOC4 genes. Conclusion Non-genital cutaneous warts exhibit a unique CpG methylation signature." @default.
- W3041041105 created "2020-07-16" @default.
- W3041041105 creator A5036659681 @default.
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- W3041041105 date "2020-07-08" @default.
- W3041041105 modified "2023-09-23" @default.
- W3041041105 title "Genome-wide identification of methylated CpG sites in nongenital cutaneous warts" @default.
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- W3041041105 doi "https://doi.org/10.1186/s12920-020-00745-6" @default.
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