FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041159306> ?p ?o ?g. }

• W3041159306 endingPage "109863" @default.
• W3041159306 startingPage "109863" @default.
• W3041159306 abstract "Phthalate exposure and oxidative stress have been linked to adverse reproductive outcomes in experimental studies, whereas no clear line has been drawn for human, especially in pregnant women. This study explored relationships between urinary phthalate metabolites and biomarkers of lipid peroxidation and oxidative and nitrosative DNA damage. Measurements from 97 Taiwanese pregnant women were taken at three different times during second and third trimesters. Five oxidative/nitrosative stress biomarkers – 8-hydroxy-2′-deoxyguanosine (8-OHdG), 8-nitroguanine (8-NO2Gua), 4-hydroxy-2-nonenal-mercapturic acid (HNE-MA), 8-isoprostaglandin F2α (8-isoPF2α), and malondialdehyde (MDA), and 11 phthalate metabolites were measured in urine samples. Linear regressions in each visit and linear mixed-model regressions were fitted to estimate percent changes in oxidative/nitrosative stress biomarkers resulting from inter-tertile increase of phthalate metabolite level and the cumulative concentrations of di (2-ethylhexyl) phthalate (DEHP) and dibutyl phthalate. The highest urine concentrations of phthalate metabolites and the greatest number of significant positive associations between phthalate metabolites and oxidative/nitrosative stress biomarkers were observed in the third visit and in repeated measurements analysis, respectively. Of the biomarkers related to DNA damage, 8-OHdG (25.4% inter-tertile increase for mono-iso-butyl phthalate) was more sensitive to phthalate exposure than 8-NO2Gua. Among the biomarkers of lipid peroxidation, HNE-MA (61.2% inter-tertile increase for sum of DEHP metabolites) was more sensitive than 8-isoPF2α and MDA. Our findings support the hypothesis that pregnant phthalate exposure increases the oxidative stress biomarkers of DNA damage and lipid peroxidation. Future research may elucidate the mediating roles of oxidative/nitrosative stress biomarkers in the link between phthalate exposure and adverse reproductive outcomes." @default.
• W3041159306 created "2020-07-16" @default.
• W3041159306 creator A5000633365 @default.
• W3041159306 creator A5027663338 @default.
• W3041159306 creator A5030837193 @default.
• W3041159306 creator A5035134037 @default.
• W3041159306 creator A5052417550 @default.
• W3041159306 creator A5064364450 @default.
• W3041159306 creator A5068541288 @default.
• W3041159306 creator A5075837730 @default.
• W3041159306 date "2020-09-01" @default.
• W3041159306 modified "2023-10-16" @default.
• W3041159306 title "Urinary phthalate metabolites are associated with biomarkers of DNA damage and lipid peroxidation in pregnant women – Tainan Birth Cohort Study (TBCS)" @default.
• W3041159306 cites W1964043583 @default.
• W3041159306 cites W1971246747 @default.
• W3041159306 cites W1976828750 @default.
• W3041159306 cites W1987452241 @default.
• W3041159306 cites W1989123468 @default.
• W3041159306 cites W1991428500 @default.
• W3041159306 cites W2002528012 @default.
• W3041159306 cites W2012396605 @default.
• W3041159306 cites W2016709601 @default.
• W3041159306 cites W2019095198 @default.
• W3041159306 cites W2020126595 @default.
• W3041159306 cites W2033984972 @default.
• W3041159306 cites W2041454621 @default.
• W3041159306 cites W2049692921 @default.
• W3041159306 cites W2081462451 @default.
• W3041159306 cites W2088501367 @default.
• W3041159306 cites W2094343211 @default.
• W3041159306 cites W2104577684 @default.
• W3041159306 cites W2117843333 @default.
• W3041159306 cites W2117897211 @default.
• W3041159306 cites W2259771847 @default.
• W3041159306 cites W2294869239 @default.
• W3041159306 cites W2295495663 @default.
• W3041159306 cites W2496298352 @default.
• W3041159306 cites W2523520347 @default.
• W3041159306 cites W2558797449 @default.
• W3041159306 cites W2562133714 @default.
• W3041159306 cites W2568114621 @default.
• W3041159306 cites W2599106007 @default.
• W3041159306 cites W2612650112 @default.
• W3041159306 cites W2761041711 @default.
• W3041159306 cites W2767711320 @default.
• W3041159306 cites W2769640448 @default.
• W3041159306 cites W2794079576 @default.
• W3041159306 cites W2808132051 @default.
• W3041159306 cites W2886795625 @default.
• W3041159306 cites W2887527191 @default.
• W3041159306 cites W2896861660 @default.
• W3041159306 cites W2916689280 @default.
• W3041159306 cites W2917712239 @default.
• W3041159306 cites W2943397447 @default.
• W3041159306 cites W2945426393 @default.
• W3041159306 cites W2946588445 @default.
• W3041159306 cites W2962800071 @default.
• W3041159306 cites W2969842276 @default.
• W3041159306 cites W2980416691 @default.
• W3041159306 cites W2988436201 @default.
• W3041159306 cites W2991616727 @default.
• W3041159306 cites W3018522334 @default.
• W3041159306 cites W3019905638 @default.
• W3041159306 cites W3030477812 @default.
• W3041159306 cites W571529032 @default.
• W3041159306 doi "https://doi.org/10.1016/j.envres.2020.109863" @default.
• W3041159306 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32846647" @default.
• W3041159306 hasPublicationYear "2020" @default.
• W3041159306 type Work @default.
• W3041159306 sameAs 3041159306 @default.
• W3041159306 citedByCount "24" @default.
• W3041159306 countsByYear W30411593062021 @default.
• W3041159306 countsByYear W30411593062022 @default.
• W3041159306 countsByYear W30411593062023 @default.
• W3041159306 crossrefType "journal-article" @default.
• W3041159306 hasAuthorship W3041159306A5000633365 @default.
• W3041159306 hasAuthorship W3041159306A5027663338 @default.
• W3041159306 hasAuthorship W3041159306A5030837193 @default.
• W3041159306 hasAuthorship W3041159306A5035134037 @default.
• W3041159306 hasAuthorship W3041159306A5052417550 @default.
• W3041159306 hasAuthorship W3041159306A5064364450 @default.
• W3041159306 hasAuthorship W3041159306A5068541288 @default.
• W3041159306 hasAuthorship W3041159306A5075837730 @default.
• W3041159306 hasConcept C126322002 @default.
• W3041159306 hasConcept C178790620 @default.
• W3041159306 hasConcept C185592680 @default.
• W3041159306 hasConcept C2776151105 @default.
• W3041159306 hasConcept C2777477808 @default.
• W3041159306 hasConcept C2778401633 @default.
• W3041159306 hasConcept C2779643248 @default.
• W3041159306 hasConcept C2780026642 @default.
• W3041159306 hasConcept C2780829032 @default.
• W3041159306 hasConcept C2781005124 @default.
• W3041159306 hasConcept C42407357 @default.
• W3041159306 hasConcept C55493867 @default.
• W3041159306 hasConcept C71924100 @default.
• W3041159306 hasConcept C77411442 @default.
• W3041159306 hasConceptScore W3041159306C126322002 @default.

• next