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- W3041185009 abstract "Ferroptosis is an iron-dependent form of cell death characterized by intracellular lipid peroxide accumulation and redox imbalance. Ferroptosis shows specific biological and morphological features when compared to the other cell death patterns. The loss of lipid peroxide repair activity by glutathione peroxidase 4 (GPX4), the presence of redox-active iron and the oxidation of polyunsaturated fatty acid (PUFA)-containing phospholipids are considered as distinct fingerprints of ferroptosis. Several pathways, including amino acid and iron metabolism, ferritinophagy, cell adhesion, p53, Keap1/Nrf2 and phospholipid biosynthesis, can modify susceptibility to ferroptosis. Through the decades, various diseases, including acute kidney injury; cancer; ischemia–reperfusion injury; and cardiovascular, neurodegenerative and hepatic disorders, have been associated with ferroptosis. In this review, we provide a comprehensive analysis of the main biological and biochemical mechanisms of ferroptosis and an overview of chemicals used as inducers and inhibitors. Then, we report the contribution of ferroptosis to the spectrum of liver diseases, acute or chronic. Finally, we discuss the use of ferroptosis as a therapeutic approach against hepatocellular carcinoma, the most common form of primary liver cancer." @default.
- W3041185009 created "2020-07-16" @default.
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- W3041185009 date "2020-07-11" @default.
- W3041185009 modified "2023-10-17" @default.
- W3041185009 title "Ferroptosis in Liver Diseases: An Overview" @default.
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- W3041185009 cites W1798710600 @default.
- W3041185009 cites W1966824235 @default.
- W3041185009 cites W197322975 @default.
- W3041185009 cites W1976197525 @default.
- W3041185009 cites W1992724001 @default.
- W3041185009 cites W1994940056 @default.
- W3041185009 cites W1996152690 @default.
- W3041185009 cites W1997183854 @default.
- W3041185009 cites W2000087607 @default.
- W3041185009 cites W2006999442 @default.
- W3041185009 cites W2017498511 @default.
- W3041185009 cites W2035898183 @default.
- W3041185009 cites W2057632732 @default.
- W3041185009 cites W2062812115 @default.
- W3041185009 cites W2071980307 @default.
- W3041185009 cites W2089755573 @default.
- W3041185009 cites W2100671540 @default.
- W3041185009 cites W2138015656 @default.
- W3041185009 cites W2145202143 @default.
- W3041185009 cites W2151866938 @default.
- W3041185009 cites W2163005196 @default.
- W3041185009 cites W2165072468 @default.
- W3041185009 cites W2180777157 @default.
- W3041185009 cites W2265062179 @default.
- W3041185009 cites W2514722514 @default.
- W3041185009 cites W2529409645 @default.
- W3041185009 cites W2549188196 @default.
- W3041185009 cites W2559023847 @default.
- W3041185009 cites W2587925611 @default.
- W3041185009 cites W2592029987 @default.
- W3041185009 cites W2592384159 @default.
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- W3041185009 cites W2599336749 @default.
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- W3041185009 doi "https://doi.org/10.3390/ijms21144908" @default.
- W3041185009 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7404091" @default.
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