FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041279191> ?p ?o ?g. }

• W3041279191 endingPage "110079" @default.
• W3041279191 startingPage "110079" @default.
• W3041279191 abstract "The traditional formulation of ibuprofen is poorly soluble in water, so the administered dose must be 10 times higher than the dose required for a therapeutic effect. The development of a hydrosoluble form of ibuprofen can be a strategy to reach a high concentration in the lungs by using modern inhalation devices. Therefore, the development of an inhalable formulation with high bioavailability in the lungs was the leitmotiv of our investigation. The hypertonic ibuprofen solution to be nebulized (NIH) presents great relevant characteristics: bactericidal, virucidal, mucolytic and has a known anti-inflammatory property. Bactericidal and virucidal effects are related to the physico-chemical properties of Na-ibuprofenate as an amphipathic molecule. It has the capability to insert into the bilayer membranes destabilizing the structure, altering its biological properties and avoiding the duplication or infection. Our preliminary results indicate that the presence of this high ionic strength solution reduces 10 times the amount of ibuprofen necessary to kill bacteria, but also the time to kill 1x106 bacteria, from 4 h (in its absence) to only three minutes (in its presence). That was observed using Pseudomona aeruginosa, methicillin-resistant Staphylococcus aureus and Burkholderia cepacia. Also, “in vitro'' ibuprofen demonstrated virucidal activity against the so-called enveloped virus, a family that includes coronavirus strain (2019-nCoV). We observed too, the markedly reduced local inflammation in the airways after administering NIH lays on its ability to inhibit the enzyme cyclooxygenase and to markedly diminish reactive oxygen species (ROS). Other investigators also showed the importance of actin in the rapid spread of virus infection. Furthermore, reorganization of the actin filaments is a key step in lung inflammation induced by systemic inflammatory responses caused by SARS-CoV-2. These findings suggest that the interaction between actin proteins and S1 is involved in the 2019-nCoV infection and pathogenesis. Consequently, the possibility of interfering in this interaction could represent a valid hypothesis for the development of promising therapeutic and prevention strategies. In conclusion, we consider that treating people with COVID-19 with NIH may be beneficial and an opportunity to contribute for the current global health emergency." @default.
• W3041279191 created "2020-07-16" @default.
• W3041279191 creator A5029719116 @default.
• W3041279191 creator A5044158052 @default.
• W3041279191 creator A5058682795 @default.
• W3041279191 creator A5071772768 @default.
• W3041279191 creator A5079891750 @default.
• W3041279191 date "2020-11-01" @default.
• W3041279191 modified "2023-10-06" @default.
• W3041279191 title "Ibuprofen, a traditional drug that may impact the course of COVID-19 new effective formulation in nebulizable solution" @default.
• W3041279191 cites W2010674927 @default.
• W3041279191 cites W2017736108 @default.
• W3041279191 cites W2020009024 @default.
• W3041279191 cites W2029221341 @default.
• W3041279191 cites W2065542923 @default.
• W3041279191 cites W2070573469 @default.
• W3041279191 cites W2080480863 @default.
• W3041279191 cites W2091046843 @default.
• W3041279191 cites W2110959690 @default.
• W3041279191 cites W2123039694 @default.
• W3041279191 cites W2126672298 @default.
• W3041279191 cites W2147678877 @default.
• W3041279191 cites W2336210752 @default.
• W3041279191 cites W2466466163 @default.
• W3041279191 cites W2782418238 @default.
• W3041279191 cites W2804271522 @default.
• W3041279191 cites W2806716492 @default.
• W3041279191 cites W3021939159 @default.
• W3041279191 cites W4235662627 @default.
• W3041279191 doi "https://doi.org/10.1016/j.mehy.2020.110079" @default.
• W3041279191 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7340056" @default.
• W3041279191 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32758897" @default.
• W3041279191 hasPublicationYear "2020" @default.
• W3041279191 type Work @default.
• W3041279191 sameAs 3041279191 @default.
• W3041279191 citedByCount "12" @default.
• W3041279191 countsByYear W30412791912020 @default.
• W3041279191 countsByYear W30412791912021 @default.
• W3041279191 countsByYear W30412791912022 @default.
• W3041279191 countsByYear W30412791912023 @default.
• W3041279191 crossrefType "journal-article" @default.
• W3041279191 hasAuthorship W3041279191A5029719116 @default.
• W3041279191 hasAuthorship W3041279191A5044158052 @default.
• W3041279191 hasAuthorship W3041279191A5058682795 @default.
• W3041279191 hasAuthorship W3041279191A5071772768 @default.
• W3041279191 hasAuthorship W3041279191A5079891750 @default.
• W3041279191 hasBestOaLocation W30412791911 @default.
• W3041279191 hasConcept C181389837 @default.
• W3041279191 hasConcept C185592680 @default.
• W3041279191 hasConcept C202751555 @default.
• W3041279191 hasConcept C2779944601 @default.
• W3041279191 hasConcept C2780035454 @default.
• W3041279191 hasConcept C523546767 @default.
• W3041279191 hasConcept C54355233 @default.
• W3041279191 hasConcept C55493867 @default.
• W3041279191 hasConcept C71924100 @default.
• W3041279191 hasConcept C86803240 @default.
• W3041279191 hasConcept C89423630 @default.
• W3041279191 hasConcept C98274493 @default.
• W3041279191 hasConceptScore W3041279191C181389837 @default.
• W3041279191 hasConceptScore W3041279191C185592680 @default.
• W3041279191 hasConceptScore W3041279191C202751555 @default.
• W3041279191 hasConceptScore W3041279191C2779944601 @default.
• W3041279191 hasConceptScore W3041279191C2780035454 @default.
• W3041279191 hasConceptScore W3041279191C523546767 @default.
• W3041279191 hasConceptScore W3041279191C54355233 @default.
• W3041279191 hasConceptScore W3041279191C55493867 @default.
• W3041279191 hasConceptScore W3041279191C71924100 @default.
• W3041279191 hasConceptScore W3041279191C86803240 @default.
• W3041279191 hasConceptScore W3041279191C89423630 @default.
• W3041279191 hasConceptScore W3041279191C98274493 @default.
• W3041279191 hasFunder F4320321594 @default.
• W3041279191 hasLocation W30412791911 @default.
• W3041279191 hasLocation W30412791912 @default.
• W3041279191 hasLocation W30412791913 @default.
• W3041279191 hasLocation W30412791914 @default.
• W3041279191 hasOpenAccess W3041279191 @default.
• W3041279191 hasPrimaryLocation W30412791911 @default.
• W3041279191 hasRelatedWork W118449968 @default.
• W3041279191 hasRelatedWork W1508531867 @default.
• W3041279191 hasRelatedWork W2030193124 @default.
• W3041279191 hasRelatedWork W2616206605 @default.
• W3041279191 hasRelatedWork W2744667494 @default.
• W3041279191 hasRelatedWork W3024440267 @default.
• W3041279191 hasRelatedWork W4307128310 @default.
• W3041279191 hasRelatedWork W1803920969 @default.
• W3041279191 hasRelatedWork W2181418653 @default.
• W3041279191 hasRelatedWork W2184264123 @default.
• W3041279191 hasVolume "144" @default.
• W3041279191 isParatext "false" @default.
• W3041279191 isRetracted "false" @default.
• W3041279191 magId "3041279191" @default.
• W3041279191 workType "article" @default.