Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041330471> ?p ?o ?g. }
- W3041330471 endingPage "339" @default.
- W3041330471 startingPage "326" @default.
- W3041330471 abstract "The transcription factor (TF) GATA2 plays a key role in organ development and cell fate control in the central nervous, urogenital, respiratory, and reproductive systems, and in primitive and definitive hematopoiesis. Here, we generate a knockin protein reporter mouse line expressing a GATA2VENUS fusion from the endogenous Gata2 genomic locus, with correct expression and localization of GATA2VENUS in different organs. GATA2VENUS expression is heterogeneous in different hematopoietic stem and progenitor cell populations (HSPCs), identifies functionally distinct subsets, and suggests a novel monocyte and mast cell lineage bifurcation point. GATA2 levels further correlate with proliferation and lineage outcome of hematopoietic progenitors. The GATA2VENUS mouse line improves the identification of specific live cell types during embryonic and adult development and will be crucial for analyzing GATA2 protein dynamics in TF networks." @default.
- W3041330471 created "2020-07-16" @default.
- W3041330471 creator A5018642486 @default.
- W3041330471 creator A5022038247 @default.
- W3041330471 creator A5028825630 @default.
- W3041330471 creator A5030702637 @default.
- W3041330471 creator A5048767709 @default.
- W3041330471 creator A5066305023 @default.
- W3041330471 creator A5083048041 @default.
- W3041330471 creator A5087616533 @default.
- W3041330471 date "2020-08-01" @default.
- W3041330471 modified "2023-10-04" @default.
- W3041330471 title "A Novel GATA2 Protein Reporter Mouse Reveals Hematopoietic Progenitor Cell Types" @default.
- W3041330471 cites W1588611448 @default.
- W3041330471 cites W1631782483 @default.
- W3041330471 cites W1669533272 @default.
- W3041330471 cites W1908752021 @default.
- W3041330471 cites W1967558440 @default.
- W3041330471 cites W1968838156 @default.
- W3041330471 cites W1971075145 @default.
- W3041330471 cites W1971958267 @default.
- W3041330471 cites W1985739269 @default.
- W3041330471 cites W1988438225 @default.
- W3041330471 cites W1988479465 @default.
- W3041330471 cites W1992904489 @default.
- W3041330471 cites W1994254285 @default.
- W3041330471 cites W1994892791 @default.
- W3041330471 cites W2008300544 @default.
- W3041330471 cites W2013587414 @default.
- W3041330471 cites W2021516648 @default.
- W3041330471 cites W2023229889 @default.
- W3041330471 cites W2024520070 @default.
- W3041330471 cites W2026640401 @default.
- W3041330471 cites W2027703497 @default.
- W3041330471 cites W2031911979 @default.
- W3041330471 cites W2039210066 @default.
- W3041330471 cites W2040476278 @default.
- W3041330471 cites W2041106449 @default.
- W3041330471 cites W2045362835 @default.
- W3041330471 cites W2045960786 @default.
- W3041330471 cites W2052426861 @default.
- W3041330471 cites W2062818637 @default.
- W3041330471 cites W2070154483 @default.
- W3041330471 cites W2072910248 @default.
- W3041330471 cites W2076116049 @default.
- W3041330471 cites W2077330278 @default.
- W3041330471 cites W2078904484 @default.
- W3041330471 cites W2083385452 @default.
- W3041330471 cites W2085587042 @default.
- W3041330471 cites W2085588348 @default.
- W3041330471 cites W2089659692 @default.
- W3041330471 cites W2090786449 @default.
- W3041330471 cites W2094930641 @default.
- W3041330471 cites W2103121534 @default.
- W3041330471 cites W2104994033 @default.
- W3041330471 cites W2106522553 @default.
- W3041330471 cites W2112010307 @default.
- W3041330471 cites W2112344820 @default.
- W3041330471 cites W2112616936 @default.
- W3041330471 cites W2127424952 @default.
- W3041330471 cites W2130699016 @default.
- W3041330471 cites W2136182167 @default.
- W3041330471 cites W2137465688 @default.
- W3041330471 cites W2145064410 @default.
- W3041330471 cites W2150731845 @default.
- W3041330471 cites W2161300409 @default.
- W3041330471 cites W2169635206 @default.
- W3041330471 cites W2192104980 @default.
- W3041330471 cites W2288267116 @default.
- W3041330471 cites W2325223081 @default.
- W3041330471 cites W2473235403 @default.
- W3041330471 cites W2583305789 @default.
- W3041330471 cites W2592920807 @default.
- W3041330471 cites W2622865236 @default.
- W3041330471 cites W2767482076 @default.
- W3041330471 cites W2770857514 @default.
- W3041330471 cites W2772643960 @default.
- W3041330471 cites W2777312512 @default.
- W3041330471 cites W2791981702 @default.
- W3041330471 cites W2794765397 @default.
- W3041330471 cites W2891873583 @default.
- W3041330471 cites W2896178814 @default.
- W3041330471 cites W2911864427 @default.
- W3041330471 cites W3002219094 @default.
- W3041330471 doi "https://doi.org/10.1016/j.stemcr.2020.06.008" @default.
- W3041330471 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7419669" @default.
- W3041330471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32649900" @default.
- W3041330471 hasPublicationYear "2020" @default.
- W3041330471 type Work @default.
- W3041330471 sameAs 3041330471 @default.
- W3041330471 citedByCount "11" @default.
- W3041330471 countsByYear W30413304712021 @default.
- W3041330471 countsByYear W30413304712022 @default.
- W3041330471 countsByYear W30413304712023 @default.
- W3041330471 crossrefType "journal-article" @default.
- W3041330471 hasAuthorship W3041330471A5018642486 @default.
- W3041330471 hasAuthorship W3041330471A5022038247 @default.
- W3041330471 hasAuthorship W3041330471A5028825630 @default.