Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041370355> ?p ?o ?g. }
- W3041370355 abstract "Macrophages are components of the innate immune system with key roles in tissue inflammation and repair. It is now evident that macrophages also support organogenesis, but few studies have characterized their identity, ontogeny and function during heart development. Here, we show that the distribution and prevalence of resident macrophages in the subepicardial compartment of the developing heart coincides with the emergence of new lymphatics, and that macrophages interact closely with the nascent lymphatic capillaries. Consequently, global macrophage deficiency led to extensive vessel disruption, with mutant hearts exhibiting shortened and mis-patterned lymphatics. The origin of cardiac macrophages was linked to the yolk sac and foetal liver. Moreover, the Cx3cr1+ myeloid lineage was found to play essential functions in the remodelling of the lymphatic endothelium. Mechanistically, macrophage hyaluronan was required for lymphatic sprouting by mediating direct macrophage-lymphatic endothelial cell interactions. Together, these findings reveal insight into the role of macrophages as indispensable mediators of lymphatic growth during the development of the mammalian cardiac vasculature." @default.
- W3041370355 created "2020-07-16" @default.
- W3041370355 creator A5001124897 @default.
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- W3041370355 creator A5086937841 @default.
- W3041370355 date "2021-02-01" @default.
- W3041370355 modified "2023-10-15" @default.
- W3041370355 title "Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart" @default.
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- W3041370355 doi "https://doi.org/10.1242/dev.194563" @default.