FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041452504> ?p ?o ?g. }

• W3041452504 endingPage "650" @default.
• W3041452504 startingPage "650" @default.
• W3041452504 abstract "The use of controlled delivery therapy in colorectal cancer (CRC) reduces toxicity and side effects. Recently, we have suggested that the Frizzled 10 (FZD10) protein, a cell surface receptor belonging to the FZD protein family that is overexpressed in CRC cells, is a novel candidate for targeting and treatment of CRC. Here, the anticancer effect of novel immuno-liposomes loaded with 5-Fluorouracil (5-FU), decorated with an antibody against FZD10 (anti-FZD10/5-FU/LPs), was evaluated in vitro on two different CRC cell lines, namely metastatic CoLo-205 and nonmetastatic CaCo-2 cells, that were found to overexpress FZD10. The anti-FZD10/5-FU/LPs obtained were extensively characterized and their preclinical therapeutic efficacy was evaluated with the MTS cell proliferation assay based on reduction of tetrazolium compound, scratch test, Field Emission Scanning Electron Microscopes (FE-SEM) investigation and immunofluorescence analysis. The results highlighted that the cytotoxic activity of 5-FU was enhanced when encapsulated in the anti-FZD10 /5-FU/LPs at the lowest tested concentrations, as compared to the free 5-FU counterparts. The immuno-liposomes proposed herein possess a great potential for selective treatment of CRC because, in future clinical applications, they can be encapsulated in gastro-resistant capsules or suppositories for oral or rectal delivery, thereby successfully reaching the intestinal tract in a minimally invasive manner." @default.
• W3041452504 created "2020-07-16" @default.
• W3041452504 creator A5001899541 @default.
• W3041452504 creator A5021199408 @default.
• W3041452504 creator A5025868627 @default.
• W3041452504 creator A5034343115 @default.
• W3041452504 creator A5059230325 @default.
• W3041452504 creator A5075457339 @default.
• W3041452504 creator A5084004711 @default.
• W3041452504 creator A5091296814 @default.
• W3041452504 date "2020-07-10" @default.
• W3041452504 modified "2023-09-27" @default.
• W3041452504 title "Effectiveness of a Controlled 5-FU Delivery Based on FZD10 Antibody-Conjugated Liposomes in Colorectal Cancer In vitro Models" @default.
• W3041452504 cites W1520580849 @default.
• W3041452504 cites W1593773421 @default.
• W3041452504 cites W1842994045 @default.
• W3041452504 cites W1973955570 @default.
• W3041452504 cites W1977748829 @default.
• W3041452504 cites W1981280742 @default.
• W3041452504 cites W1984400293 @default.
• W3041452504 cites W1985822043 @default.
• W3041452504 cites W1985856395 @default.
• W3041452504 cites W1995097523 @default.
• W3041452504 cites W2000467802 @default.
• W3041452504 cites W2023182484 @default.
• W3041452504 cites W2035639954 @default.
• W3041452504 cites W2038887440 @default.
• W3041452504 cites W2042767443 @default.
• W3041452504 cites W2049807473 @default.
• W3041452504 cites W2074075725 @default.
• W3041452504 cites W2074913968 @default.
• W3041452504 cites W2082511916 @default.
• W3041452504 cites W2087876668 @default.
• W3041452504 cites W2091513731 @default.
• W3041452504 cites W2093823863 @default.
• W3041452504 cites W2095142763 @default.
• W3041452504 cites W2100592123 @default.
• W3041452504 cites W2125775002 @default.
• W3041452504 cites W2130392703 @default.
• W3041452504 cites W2136222218 @default.
• W3041452504 cites W2142287269 @default.
• W3041452504 cites W2156279250 @default.
• W3041452504 cites W2168209392 @default.
• W3041452504 cites W2207065060 @default.
• W3041452504 cites W2238976895 @default.
• W3041452504 cites W2314430385 @default.
• W3041452504 cites W2338323471 @default.
• W3041452504 cites W2555270343 @default.
• W3041452504 cites W2560322684 @default.
• W3041452504 cites W2583187361 @default.
• W3041452504 cites W2588121804 @default.
• W3041452504 cites W2594440456 @default.
• W3041452504 cites W2601865694 @default.
• W3041452504 cites W2775498213 @default.
• W3041452504 cites W2790095183 @default.
• W3041452504 cites W2804103434 @default.
• W3041452504 cites W2889835308 @default.
• W3041452504 cites W2895022487 @default.
• W3041452504 cites W2915957883 @default.
• W3041452504 cites W2946884700 @default.
• W3041452504 cites W2957127208 @default.
• W3041452504 cites W2961496244 @default.
• W3041452504 cites W2985825177 @default.
• W3041452504 cites W2997015672 @default.
• W3041452504 cites W3000072346 @default.
• W3041452504 cites W3009908793 @default.
• W3041452504 cites W3045342994 @default.
• W3041452504 cites W4237212024 @default.
• W3041452504 doi "https://doi.org/10.3390/pharmaceutics12070650" @default.
• W3041452504 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7408534" @default.
• W3041452504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32664186" @default.
• W3041452504 hasPublicationYear "2020" @default.
• W3041452504 type Work @default.
• W3041452504 sameAs 3041452504 @default.
• W3041452504 citedByCount "18" @default.
• W3041452504 countsByYear W30414525042021 @default.
• W3041452504 countsByYear W30414525042022 @default.
• W3041452504 countsByYear W30414525042023 @default.
• W3041452504 crossrefType "journal-article" @default.
• W3041452504 hasAuthorship W3041452504A5001899541 @default.
• W3041452504 hasAuthorship W3041452504A5021199408 @default.
• W3041452504 hasAuthorship W3041452504A5025868627 @default.
• W3041452504 hasAuthorship W3041452504A5034343115 @default.
• W3041452504 hasAuthorship W3041452504A5059230325 @default.
• W3041452504 hasAuthorship W3041452504A5075457339 @default.
• W3041452504 hasAuthorship W3041452504A5084004711 @default.
• W3041452504 hasAuthorship W3041452504A5091296814 @default.
• W3041452504 hasBestOaLocation W30414525041 @default.
• W3041452504 hasConcept C121608353 @default.
• W3041452504 hasConcept C126322002 @default.
• W3041452504 hasConcept C159654299 @default.
• W3041452504 hasConcept C185154212 @default.
• W3041452504 hasConcept C185592680 @default.
• W3041452504 hasConcept C202751555 @default.
• W3041452504 hasConcept C203014093 @default.
• W3041452504 hasConcept C2778236600 @default.
• W3041452504 hasConcept C502942594 @default.
• W3041452504 hasConcept C526805850 @default.

• next