Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041465124> ?p ?o ?g. }
- W3041465124 endingPage "4945" @default.
- W3041465124 startingPage "4945" @default.
- W3041465124 abstract "Hepatitis C virus (HCV) infections can cause permanent liver-related diseases, including hepatocellular carcinoma (HCC). Low mortality and incidence of HCC have been observed in patients with chronic hepatitis C undergoing direct-acting antiviral therapy. Tumor suppressive let-7 family members are down-regulated in HCC. The present study, therefore, aimed to investigate whether expression levels for the full spectrum of let-7 family members (let-7a, 7b, 7c, 7d, 7e, 7f, 7g, 7i, and miR-98) in the circulatory system are useful as surveillance biomarkers for liver-related diseases to monitor treatment efficacy during HCV infection. To this end, we measured the levels of mature circulating let-7 family members using quantitative reverse transcription-PCR in 236 patients with HCV infection, and 147 age- and sex-matched controls. Using hierarchical cluster analysis and principal component analysis, three clusters were obtained after measuring expression levels of let-7 family members in the patients and controls. Cluster 1 included let-7a/d/e/g, Cluster 2 comprised let-7b and let-7i, and Cluster 3 comprised let-7c/f/miR-98. Let-7b/c/g represented the three clusters and showed the best survival response to liver cancer when analyzed with respect to patient data. Therefore, considering the circulating levels of let7 b/c/g as representatives of the let-7 family may facilitate effective monitoring of liver-related disease." @default.
- W3041465124 created "2020-07-16" @default.
- W3041465124 creator A5006299777 @default.
- W3041465124 creator A5009330208 @default.
- W3041465124 creator A5029851407 @default.
- W3041465124 creator A5046862705 @default.
- W3041465124 creator A5049658299 @default.
- W3041465124 creator A5053770056 @default.
- W3041465124 creator A5057578521 @default.
- W3041465124 creator A5062736490 @default.
- W3041465124 creator A5071989098 @default.
- W3041465124 creator A5072593323 @default.
- W3041465124 creator A5078365368 @default.
- W3041465124 creator A5081580592 @default.
- W3041465124 creator A5091602628 @default.
- W3041465124 date "2020-07-13" @default.
- W3041465124 modified "2023-10-17" @default.
- W3041465124 title "Clusters of Circulating let-7 Family Tumor Suppressors Are Associated with Clinical Characteristics of Chronic Hepatitis C" @default.
- W3041465124 cites W1798005823 @default.
- W3041465124 cites W1964787482 @default.
- W3041465124 cites W1965152588 @default.
- W3041465124 cites W1973027060 @default.
- W3041465124 cites W1983932066 @default.
- W3041465124 cites W1993346317 @default.
- W3041465124 cites W2005440577 @default.
- W3041465124 cites W2012913468 @default.
- W3041465124 cites W2013040998 @default.
- W3041465124 cites W2014666790 @default.
- W3041465124 cites W2037155102 @default.
- W3041465124 cites W2048422492 @default.
- W3041465124 cites W2053978445 @default.
- W3041465124 cites W2054312277 @default.
- W3041465124 cites W2065582958 @default.
- W3041465124 cites W2083381199 @default.
- W3041465124 cites W2097233439 @default.
- W3041465124 cites W2102577928 @default.
- W3041465124 cites W2115093090 @default.
- W3041465124 cites W2122906372 @default.
- W3041465124 cites W2123049088 @default.
- W3041465124 cites W2127060044 @default.
- W3041465124 cites W2136095707 @default.
- W3041465124 cites W2137417346 @default.
- W3041465124 cites W2142489285 @default.
- W3041465124 cites W2149918501 @default.
- W3041465124 cites W2150536104 @default.
- W3041465124 cites W2152310279 @default.
- W3041465124 cites W2153720399 @default.
- W3041465124 cites W2157085831 @default.
- W3041465124 cites W2165104559 @default.
- W3041465124 cites W2329116257 @default.
- W3041465124 cites W2401657071 @default.
- W3041465124 cites W2419287127 @default.
- W3041465124 cites W2584683409 @default.
- W3041465124 cites W2590432698 @default.
- W3041465124 cites W2744914748 @default.
- W3041465124 cites W2761184186 @default.
- W3041465124 doi "https://doi.org/10.3390/ijms21144945" @default.
- W3041465124 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7404305" @default.
- W3041465124 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32668728" @default.
- W3041465124 hasPublicationYear "2020" @default.
- W3041465124 type Work @default.
- W3041465124 sameAs 3041465124 @default.
- W3041465124 citedByCount "8" @default.
- W3041465124 countsByYear W30414651242021 @default.
- W3041465124 countsByYear W30414651242022 @default.
- W3041465124 countsByYear W30414651242023 @default.
- W3041465124 crossrefType "journal-article" @default.
- W3041465124 hasAuthorship W3041465124A5006299777 @default.
- W3041465124 hasAuthorship W3041465124A5009330208 @default.
- W3041465124 hasAuthorship W3041465124A5029851407 @default.
- W3041465124 hasAuthorship W3041465124A5046862705 @default.
- W3041465124 hasAuthorship W3041465124A5049658299 @default.
- W3041465124 hasAuthorship W3041465124A5053770056 @default.
- W3041465124 hasAuthorship W3041465124A5057578521 @default.
- W3041465124 hasAuthorship W3041465124A5062736490 @default.
- W3041465124 hasAuthorship W3041465124A5071989098 @default.
- W3041465124 hasAuthorship W3041465124A5072593323 @default.
- W3041465124 hasAuthorship W3041465124A5078365368 @default.
- W3041465124 hasAuthorship W3041465124A5081580592 @default.
- W3041465124 hasAuthorship W3041465124A5091602628 @default.
- W3041465124 hasBestOaLocation W30414651241 @default.
- W3041465124 hasConcept C120665830 @default.
- W3041465124 hasConcept C121332964 @default.
- W3041465124 hasConcept C121608353 @default.
- W3041465124 hasConcept C126322002 @default.
- W3041465124 hasConcept C143998085 @default.
- W3041465124 hasConcept C164866538 @default.
- W3041465124 hasConcept C199360897 @default.
- W3041465124 hasConcept C203014093 @default.
- W3041465124 hasConcept C2522874641 @default.
- W3041465124 hasConcept C2776029263 @default.
- W3041465124 hasConcept C2776231280 @default.
- W3041465124 hasConcept C2776408679 @default.
- W3041465124 hasConcept C2776455275 @default.
- W3041465124 hasConcept C2777075537 @default.
- W3041465124 hasConcept C2778019345 @default.
- W3041465124 hasConcept C3020491458 @default.
- W3041465124 hasConcept C41008148 @default.