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- W3041482856 endingPage "100747" @default.
- W3041482856 startingPage "100747" @default.
- W3041482856 abstract "• Formation of cell aggregates was discussed in two aspects: conventional and novel substrate-based preparation methods. • Interaction between cells and hydrogels was emphasized to reveal how hydrogels influence the formation of cell aggregates on two-dimensional (2D) hydrogel surfaces or inside three-dimensional (3D) hydrogels. • Biomedical applications of cell aggregates using 2D and 3D hydrogel-based preparation methods were compared. Cell aggregates are widely used either as in-vitro models for drug screening, fundamental studies on disease progression and developmental biology, as well as in-vivo injectable cells for tissue regeneration. Compared to single-cell suspensions, cell aggregates retain superior cell viability, mimic in-vivo microenvironments and enhance functional properties, such as superior anti-inflammatory properties of mesenchymal stem/stromal cell aggregates or enhanced albumin production by hepatocyte aggregates. Cell aggregates can be either prepared by conventional spontaneous aggregation, or advanced substrate-based and technology-assisted methods, which have been well described in previous reviews. However, hydrogel-based preparation of cell aggregates is a novel, hitherto rarely considered method compared to conventional preparation of cell aggregates, such as hanging drops and commercial AggreWell TM plates. This review will mainly focus on two-dimensional (2D) hydrogel surface -based and three-dimensional (3D) hydrogel embedding-based preparation of cell aggregates by revealing the underlying mechanisms and highlighting some of their potential biomedical applications." @default.
- W3041482856 created "2020-07-16" @default.
- W3041482856 creator A5023965532 @default.
- W3041482856 creator A5044067189 @default.
- W3041482856 creator A5060207778 @default.
- W3041482856 creator A5081392286 @default.
- W3041482856 creator A5085941424 @default.
- W3041482856 date "2020-09-01" @default.
- W3041482856 modified "2023-09-26" @default.
- W3041482856 title "Hydrogel-based preparation of cell aggregates for biomedical applications" @default.
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