Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041503457> ?p ?o ?g. }
- W3041503457 endingPage "188" @default.
- W3041503457 startingPage "153" @default.
- W3041503457 abstract "Novel therapies are needed to treat Parkinson's disease (PD) in which the clinical unmet need is pressing. Currently, no clinically available therapeutic strategy can either retard or reverse PD or repair its pathological consequences. l-DOPA (levodopa) is still the gold standard therapy for motor symptoms yet symptomatic therapies for both motor and non-motor symptoms are improving. Many on-going, intervention trials cover a broad range of targets, including cell replacement and gene therapy approaches, quality of life improving technologies, and disease-modifying strategies (e.g., controlling aberrant α-synuclein accumulation and regulating cellular/neuronal bioenergetics). Notably, the repurposing of glucagon-like peptide-1 analogues with potential disease-modifying effects based on metabolic pathology associated with PD has been promising. Nevertheless, there is a clear need for improved therapeutic and diagnostic options, disease progression tracking and patient stratification capabilities to deliver personalized treatment and optimize trial design. This review discusses some of the risk factors and consequent pathology associated with PD and particularly the metabolic aspects of PD, novel therapies targeting these pathologies (e.g., mitochondrial and lysosomal dysfunction, oxidative stress, and inflammation/neuroinflammation), including the repurposing of metabolic therapies, and unmet needs as potential drivers for future clinical trials and research in PD." @default.
- W3041503457 created "2020-07-16" @default.
- W3041503457 creator A5043002493 @default.
- W3041503457 date "2020-01-01" @default.
- W3041503457 modified "2023-09-25" @default.
- W3041503457 title "Status and future directions of clinical trials in Parkinson's disease" @default.
- W3041503457 cites W1468234800 @default.
- W3041503457 cites W1500139954 @default.
- W3041503457 cites W1544196343 @default.
- W3041503457 cites W1561611826 @default.
- W3041503457 cites W1813466775 @default.
- W3041503457 cites W1829183563 @default.
- W3041503457 cites W1829275570 @default.
- W3041503457 cites W1848685510 @default.
- W3041503457 cites W1885594328 @default.
- W3041503457 cites W1966918485 @default.
- W3041503457 cites W1975112659 @default.
- W3041503457 cites W1977817124 @default.
- W3041503457 cites W1978793506 @default.
- W3041503457 cites W1985398552 @default.
- W3041503457 cites W1985538633 @default.
- W3041503457 cites W1993829231 @default.
- W3041503457 cites W1994295468 @default.
- W3041503457 cites W1999502797 @default.
- W3041503457 cites W2014413787 @default.
- W3041503457 cites W2015283405 @default.
- W3041503457 cites W2018461735 @default.
- W3041503457 cites W2021356347 @default.
- W3041503457 cites W2031340015 @default.
- W3041503457 cites W2032870207 @default.
- W3041503457 cites W2034424279 @default.
- W3041503457 cites W2034532609 @default.
- W3041503457 cites W2035787181 @default.
- W3041503457 cites W2037752501 @default.
- W3041503457 cites W2037891639 @default.
- W3041503457 cites W2040241220 @default.
- W3041503457 cites W2044407202 @default.
- W3041503457 cites W2050647292 @default.
- W3041503457 cites W2050786534 @default.
- W3041503457 cites W2050855365 @default.
- W3041503457 cites W2055008822 @default.
- W3041503457 cites W2055308573 @default.
- W3041503457 cites W2056546282 @default.
- W3041503457 cites W2058522899 @default.
- W3041503457 cites W2060657561 @default.
- W3041503457 cites W2063448633 @default.
- W3041503457 cites W2065372294 @default.
- W3041503457 cites W2073279468 @default.
- W3041503457 cites W2077360634 @default.
- W3041503457 cites W2078589597 @default.
- W3041503457 cites W2080785707 @default.
- W3041503457 cites W2083757931 @default.
- W3041503457 cites W2091788949 @default.
- W3041503457 cites W2098097762 @default.
- W3041503457 cites W2102491127 @default.
- W3041503457 cites W2106045149 @default.
- W3041503457 cites W2111171093 @default.
- W3041503457 cites W2121562021 @default.
- W3041503457 cites W2127670282 @default.
- W3041503457 cites W2130749065 @default.
- W3041503457 cites W2133779349 @default.
- W3041503457 cites W2134369114 @default.
- W3041503457 cites W2136511786 @default.
- W3041503457 cites W2142430469 @default.
- W3041503457 cites W2144140825 @default.
- W3041503457 cites W2152728004 @default.
- W3041503457 cites W2159340140 @default.
- W3041503457 cites W2164738639 @default.
- W3041503457 cites W2168432448 @default.
- W3041503457 cites W2265657751 @default.
- W3041503457 cites W2270971263 @default.
- W3041503457 cites W2297558431 @default.
- W3041503457 cites W2301404923 @default.
- W3041503457 cites W2305411941 @default.
- W3041503457 cites W2316672773 @default.
- W3041503457 cites W2337871602 @default.
- W3041503457 cites W2340005882 @default.
- W3041503457 cites W2394573997 @default.
- W3041503457 cites W2406302344 @default.
- W3041503457 cites W2415242066 @default.
- W3041503457 cites W2465564629 @default.
- W3041503457 cites W2472509986 @default.
- W3041503457 cites W2475621263 @default.
- W3041503457 cites W2511725062 @default.
- W3041503457 cites W2516348886 @default.
- W3041503457 cites W2518558719 @default.
- W3041503457 cites W2528919078 @default.
- W3041503457 cites W2529564975 @default.
- W3041503457 cites W2555613116 @default.
- W3041503457 cites W2561600098 @default.
- W3041503457 cites W2562545595 @default.
- W3041503457 cites W2563082987 @default.
- W3041503457 cites W2574388565 @default.
- W3041503457 cites W2581159721 @default.
- W3041503457 cites W2587861045 @default.
- W3041503457 cites W2589875191 @default.
- W3041503457 cites W2590626278 @default.
- W3041503457 cites W2592063047 @default.