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- W3041560940 abstract "PURPOSE: Clinical use of platelet-rich plasma (PRP) and mesenchymal stem cells (MSCs) have gained momentum as viable treatment options for muscle injuries. Exosomes, or small cell-derived vesicles, could be helpful if they could deliver the same or better physiological effect without cell transplantation into the muscle. The purpose of this work was to determine if local delivery of exosomes derived from PRP (PRP-exos) or MSCs (MSC-exos) to injured muscles hastens recovery of contractile function. METHODS: Using Sprague-Dawley rats, platelets were isolated from blood and MSCs were isolated from bone marrow and expanded in culture; exosomes from both were isolated through ultracentrifugation. The tibialis anterior muscles were injured in vivo by maximal lengthening contractions. Muscles were injected with PRP-exos or MSC-exos (immediately after injury, and days 5 and 10 after injury); shams received an equal volume of saline. In addition, histological and biochemical analysis was performed on tissues for all groups. RESULTS: Injury resulted in a significant loss of maximal isometric torque (66 ± 3 %) that gradually recovered over 2 weeks. Both PRP-exos and MSC-exos accelerated recovery, with similar improved recovery of contractile function over the saline treated group at days 5, 10, and 15 (P < 0.05). A significant increase in centrally nucleated fibers was seen with both exos groups by day 15 (P < 0.05). Muscles treated with PRP-exos had increased expression of Myogenin gene expression (P < 0.05), whereas muscles treated with MSC-exos had reduced expression of TGF-β ten days after muscle injury. CONCLUSIONS: Exosomes derived from PRP or MSCs can facilitate recovery after a muscle strain injury in a small-animal model, likely due to factors that can modulate inflammation, fibrosis and myogenesis. With their small size, low immunogenicity, and ease with which they can be obtained, exosomes could represent a novel therapy for many orthopedic ailments." @default.
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- W3041560940 date "2020-07-01" @default.
- W3041560940 modified "2023-10-16" @default.
- W3041560940 title "Exosomes Isolated From Platelet-rich Plasma And Mesenchymal Stem Cells Promote Functional Recovery After Muscle Injury" @default.
- W3041560940 doi "https://doi.org/10.1249/01.mss.0000679516.67474.56" @default.
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