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- W3041596377 abstract "The aim of this study was to improve the solubility and dissolution of Ibrutinib (IBR), a biopharmaceutical classification system (BCS) class II drug, by coamorphization with four kind of carboxylic acids, tartaric acid (TA), citric acid (CA), malic acid (MA) and succinic acid (SA) at molar ratios of 1:1 and 2:1, and investigate the interaction mechanism between IBR and acids responsible for enhancement. Compared with crystalline IBR Form A, eight IBR-Acid coamorphous systems (CASs) showed prominent improvement in solubility and dissolution. The solubility and dissolution of IBR-TA (2:1) CAS were increased up to 3.5–5.5 times and 4.3 times than IBR Form A, which showed optimal properties. Moreover, IBR-TA (2:1) CAS kept stable amorphous state after 180 days under 40 °C/75 %RH condition and kept stable amorphous state for 30 days under 60 °C/0 %RH condition. From Fourier Transform-Infrared spectra and glass transition temperature analysis, the possible molecular interaction model in IBT-TA (2:1) CAS was proposed to explain the improvement of solubility and dissolution. The above investigation indicated that coamorphization of IBR and acid was an effective strategy to improve solubility and dissolution of poor soluble IBR." @default.
- W3041596377 created "2020-07-16" @default.
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- W3041596377 date "2020-10-01" @default.
- W3041596377 modified "2023-09-26" @default.
- W3041596377 title "Ibrutinib and carboxylic acid coamorphous system with increased solubility and dissolution: A potential interaction mechanism" @default.
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- W3041596377 doi "https://doi.org/10.1016/j.jddst.2020.101875" @default.
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