FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041636698> ?p ?o ?g. }

• W3041636698 endingPage "1039" @default.
• W3041636698 startingPage "1039" @default.
• W3041636698 abstract "Neutrophils are the most abundant innate cell population and a key immune player against invading pathogens. Neutrophils can kill both bacterium and spores of Bacillus anthracis, the causative anthrax pathogen. Unlike interactions with professional phagocytes, the molecular recognition of anthrax by neutrophils is largely unknown. In this study, we investigated the role of complement C3 deposition on anthrax particles for neutrophil recognition of bacterium and/or its cell wall peptidoglycan, an abundant pathogen-associated molecular pattern that supports anthrax sepsis. C3 opsonization and recognition by complement receptors accounted for 70–80% of the affinity interactions between neutrophils and anthrax particles at subphysiologic temperatures. In contrast, C3 supported up to 50% of the anthrax particle ingestion under thermophysiologic conditions. Opsonin-dependent low affinity interactions and, to a lower extent, opsonin-independent mechanisms, provide alternative entry routes. Similarly, C3 supported 58% of peptidoglycan-induced degranulation and, to a lower extent, 23% of bacterium-induced degranulation. Interestingly, an opsonin independent mechanism mediated by complement C5, likely through C5a anaphylatoxin, primes azurophilic granules in response to anthrax particles. Overall, we show that C3 deposition supports anthrax recognition by neutrophils but is dispensable for pathogen ingestion and neutrophil degranulation, highlighting immune recognition redundancies that minimize the risk of pathogen evasion." @default.
• W3041636698 created "2020-07-16" @default.
• W3041636698 creator A5018200317 @default.
• W3041636698 creator A5023265932 @default.
• W3041636698 creator A5023330760 @default.
• W3041636698 creator A5056174184 @default.
• W3041636698 creator A5083245117 @default.
• W3041636698 date "2020-07-13" @default.
• W3041636698 modified "2023-10-06" @default.
• W3041636698 title "C3 Opsonization of Anthrax Bacterium and Peptidoglycan Supports Recognition and Activation of Neutrophils" @default.
• W3041636698 cites W1482128986 @default.
• W3041636698 cites W1520756401 @default.
• W3041636698 cites W1551894652 @default.
• W3041636698 cites W1559668074 @default.
• W3041636698 cites W1567665718 @default.
• W3041636698 cites W1575925203 @default.
• W3041636698 cites W1597610606 @default.
• W3041636698 cites W1610022685 @default.
• W3041636698 cites W1828020944 @default.
• W3041636698 cites W1916559700 @default.
• W3041636698 cites W1930649809 @default.
• W3041636698 cites W1964162643 @default.
• W3041636698 cites W1966964426 @default.
• W3041636698 cites W1973289394 @default.
• W3041636698 cites W1978547780 @default.
• W3041636698 cites W1991767888 @default.
• W3041636698 cites W1997839876 @default.
• W3041636698 cites W2001095885 @default.
• W3041636698 cites W2004995617 @default.
• W3041636698 cites W2015732610 @default.
• W3041636698 cites W2018147541 @default.
• W3041636698 cites W2023018499 @default.
• W3041636698 cites W2041896408 @default.
• W3041636698 cites W2041912799 @default.
• W3041636698 cites W2046380830 @default.
• W3041636698 cites W2046518441 @default.
• W3041636698 cites W2054541213 @default.
• W3041636698 cites W2057763292 @default.
• W3041636698 cites W2063847765 @default.
• W3041636698 cites W2068309990 @default.
• W3041636698 cites W2070256030 @default.
• W3041636698 cites W2080942704 @default.
• W3041636698 cites W2082218499 @default.
• W3041636698 cites W2084069113 @default.
• W3041636698 cites W2087015119 @default.
• W3041636698 cites W2090181845 @default.
• W3041636698 cites W2098557986 @default.
• W3041636698 cites W2100249681 @default.
• W3041636698 cites W2101116633 @default.
• W3041636698 cites W2101522607 @default.
• W3041636698 cites W2132252339 @default.
• W3041636698 cites W2135069977 @default.
• W3041636698 cites W2149114563 @default.
• W3041636698 cites W2149443281 @default.
• W3041636698 cites W2149709370 @default.
• W3041636698 cites W2150832852 @default.
• W3041636698 cites W2159228469 @default.
• W3041636698 cites W2627004073 @default.
• W3041636698 cites W2770867713 @default.
• W3041636698 cites W2793472432 @default.
• W3041636698 cites W2794105417 @default.
• W3041636698 cites W2808147594 @default.
• W3041636698 cites W2809067157 @default.
• W3041636698 cites W2886580403 @default.
• W3041636698 cites W2966314303 @default.
• W3041636698 cites W2968804169 @default.
• W3041636698 cites W3016627180 @default.
• W3041636698 cites W4229630303 @default.
• W3041636698 cites W4249235188 @default.
• W3041636698 cites W4253268777 @default.
• W3041636698 cites W2792460085 @default.
• W3041636698 doi "https://doi.org/10.3390/microorganisms8071039" @default.
• W3041636698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7409185" @default.
• W3041636698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32668703" @default.
• W3041636698 hasPublicationYear "2020" @default.
• W3041636698 type Work @default.
• W3041636698 sameAs 3041636698 @default.
• W3041636698 citedByCount "6" @default.
• W3041636698 countsByYear W30416366982021 @default.
• W3041636698 countsByYear W30416366982022 @default.
• W3041636698 countsByYear W30416366982023 @default.
• W3041636698 crossrefType "journal-article" @default.
• W3041636698 hasAuthorship W3041636698A5018200317 @default.
• W3041636698 hasAuthorship W3041636698A5023265932 @default.
• W3041636698 hasAuthorship W3041636698A5023330760 @default.
• W3041636698 hasAuthorship W3041636698A5056174184 @default.
• W3041636698 hasAuthorship W3041636698A5083245117 @default.
• W3041636698 hasBestOaLocation W30416366981 @default.
• W3041636698 hasConcept C136449434 @default.
• W3041636698 hasConcept C160448771 @default.
• W3041636698 hasConcept C168507396 @default.
• W3041636698 hasConcept C170493617 @default.
• W3041636698 hasConcept C174106267 @default.
• W3041636698 hasConcept C203014093 @default.
• W3041636698 hasConcept C203565725 @default.
• W3041636698 hasConcept C2776460866 @default.
• W3041636698 hasConcept C2776634448 @default.
• W3041636698 hasConcept C2776914184 @default.

• next