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• W3041723601 endingPage "105564" @default.
• W3041723601 startingPage "105564" @default.
• W3041723601 abstract "Millions of pharmaceuticals are prescribed each year. Wastewater treatment plants fail to remove all pharmaceuticals from discharge leading to detectable concentrations entering aquatic ecosystems where the compounds can encounter nontarget organisms. Selective serotonin reuptake inhibitor (SSRI) class of antidepressants interact with transporters in the brain and peripheral nervous system to change serotonin levels in the synapse. Sublethal exposure to SSRIs can impact fish feeding behaviors, which can have impacts on ecological fitness. We exposed hybrid striped bass (Morone saxatilis x Morone chrysops) to low, medium, and high concentrations of sertraline (4.5 ± 0.84 μg/L, 35.4 ± 2.18 μg/L, and 96.8 ± 6.4 μg/L) over six days with six additional recovery days. Concentrations were chosen to compare results with a mixture study previously completed in our lab. Every three days we tracked how long each bass took to consume four fathead minnows (Pimephales promelas) and conducted destructive sampling to obtain brain and plasma samples. Brain and plasma samples were analyzed for sertraline levels and we calculated whole brain serotonin levels. During the exposure period, bass showed an increased time to capture prey, but time to capture prey returned to control levels during the six-day recovery period. Sertraline was detected in brain and plasma during the duration of the experiment, though not always in a dose-dependent fashion. While we demonstrated a relationship between time to capture prey and decrease whole brain serotonin levels, the decrease in time to capture prey during the recovery period suggests the serotonin levels in the brain are not solely responsible for the outward behavioral expression observed." @default.
• W3041723601 created "2020-07-16" @default.
• W3041723601 creator A5018835103 @default.
• W3041723601 creator A5023301596 @default.
• W3041723601 date "2020-09-01" @default.
• W3041723601 modified "2023-09-26" @default.
• W3041723601 title "Effects of selective serotonin reuptake inhibitor sertraline on hybrid striped bass predatory behavior and brain chemistry" @default.
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• W3041723601 doi "https://doi.org/10.1016/j.aquatox.2020.105564" @default.
• W3041723601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32683169" @default.
• W3041723601 hasPublicationYear "2020" @default.
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