Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041729595> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3041729595 abstract "Lithium carbonate, a drug known for more than 100 years, has been successfully used as a psychiatric medication. Currently, it is a commonly used drug to treat patients with unipolar and bipolar depression, and for the prophylaxis of bipolar disorders and acute mania. Lithium salts may cause the development of goiter, hypothyroidism, or rarely hyperthyroidism. The present review examined the current state of knowledge on the effect of lithium carbonate on the thyroid gland. The Pubmed database and Google Scholar were searched for articles related to the effects of lithium therapy on the thyroid gland function published up to February 2020. Studies that examined the mechanism of action of lithium at the molecular level, including pharmacokinetics, and focused on its effects on the thyroid gland were included. Lithium as a mood-stabilizing drug has a complex mechanism of action. Because of the active transport of Na+/I- ions, lithium, despite its concentration gradient, is accumulated in the thyroid gland at a concentration 3 - 4 times higher than that in the plasma. It can inhibit the formation of colloid in thyrocytes, change the structure of thyroglobulin, weaken the iodination of tyrosines, and disrupt their coupling. In addition, it reduces the clearance of free thyroxine in the serum, thereby indirectly reducing the activity of 5-deiodinase type 1 and 2 and reducing the deiodination of these hormones in the liver. Taken together, this review provides recommendations for monitoring the thyroid gland in patients who require long-term lithium therapy. Prior to the initiation of lithium therapy, thyroid ultrasound should be performed, and the levels of thyroid hormones (fT3 and fT4), TSH, and antithyroid peroxidase and antithyroglobulin antibodies should be measured. If the patient shows normal thyroid function, TSH level measurement and thyroid ultrasound should be performed at 6- to 12-month intervals for long term." @default.
- W3041729595 created "2020-07-16" @default.
- W3041729595 creator A5004941553 @default.
- W3041729595 creator A5010799497 @default.
- W3041729595 creator A5019040298 @default.
- W3041729595 creator A5020770773 @default.
- W3041729595 creator A5037025071 @default.
- W3041729595 creator A5060538403 @default.
- W3041729595 creator A5074750100 @default.
- W3041729595 date "2020-07-02" @default.
- W3041729595 modified "2023-09-23" @default.
- W3041729595 title "Effect of lithium carbonate on the function of the thyroid gland: mechanism of action and clinical implications." @default.
- W3041729595 doi "https://doi.org/10.26402/jpp.2020.2.03" @default.
- W3041729595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32633237" @default.
- W3041729595 hasPublicationYear "2020" @default.
- W3041729595 type Work @default.
- W3041729595 sameAs 3041729595 @default.
- W3041729595 citedByCount "2" @default.
- W3041729595 countsByYear W30417295952021 @default.
- W3041729595 countsByYear W30417295952023 @default.
- W3041729595 crossrefType "journal-article" @default.
- W3041729595 hasAuthorship W3041729595A5004941553 @default.
- W3041729595 hasAuthorship W3041729595A5010799497 @default.
- W3041729595 hasAuthorship W3041729595A5019040298 @default.
- W3041729595 hasAuthorship W3041729595A5020770773 @default.
- W3041729595 hasAuthorship W3041729595A5037025071 @default.
- W3041729595 hasAuthorship W3041729595A5060538403 @default.
- W3041729595 hasAuthorship W3041729595A5074750100 @default.
- W3041729595 hasConcept C126322002 @default.
- W3041729595 hasConcept C134018914 @default.
- W3041729595 hasConcept C145148216 @default.
- W3041729595 hasConcept C178790620 @default.
- W3041729595 hasConcept C185592680 @default.
- W3041729595 hasConcept C2182769 @default.
- W3041729595 hasConcept C2776174506 @default.
- W3041729595 hasConcept C2776809841 @default.
- W3041729595 hasConcept C2778541603 @default.
- W3041729595 hasConcept C2778835679 @default.
- W3041729595 hasConcept C2780550438 @default.
- W3041729595 hasConcept C2781046926 @default.
- W3041729595 hasConcept C2993291352 @default.
- W3041729595 hasConcept C526584372 @default.
- W3041729595 hasConcept C71924100 @default.
- W3041729595 hasConcept C98274493 @default.
- W3041729595 hasConceptScore W3041729595C126322002 @default.
- W3041729595 hasConceptScore W3041729595C134018914 @default.
- W3041729595 hasConceptScore W3041729595C145148216 @default.
- W3041729595 hasConceptScore W3041729595C178790620 @default.
- W3041729595 hasConceptScore W3041729595C185592680 @default.
- W3041729595 hasConceptScore W3041729595C2182769 @default.
- W3041729595 hasConceptScore W3041729595C2776174506 @default.
- W3041729595 hasConceptScore W3041729595C2776809841 @default.
- W3041729595 hasConceptScore W3041729595C2778541603 @default.
- W3041729595 hasConceptScore W3041729595C2778835679 @default.
- W3041729595 hasConceptScore W3041729595C2780550438 @default.
- W3041729595 hasConceptScore W3041729595C2781046926 @default.
- W3041729595 hasConceptScore W3041729595C2993291352 @default.
- W3041729595 hasConceptScore W3041729595C526584372 @default.
- W3041729595 hasConceptScore W3041729595C71924100 @default.
- W3041729595 hasConceptScore W3041729595C98274493 @default.
- W3041729595 hasIssue "2" @default.
- W3041729595 hasLocation W30417295951 @default.
- W3041729595 hasOpenAccess W3041729595 @default.
- W3041729595 hasPrimaryLocation W30417295951 @default.
- W3041729595 hasRelatedWork W1983856716 @default.
- W3041729595 hasRelatedWork W2013235616 @default.
- W3041729595 hasRelatedWork W2029175984 @default.
- W3041729595 hasRelatedWork W2032455423 @default.
- W3041729595 hasRelatedWork W2051002618 @default.
- W3041729595 hasRelatedWork W2051635262 @default.
- W3041729595 hasRelatedWork W2095428609 @default.
- W3041729595 hasRelatedWork W2152645367 @default.
- W3041729595 hasRelatedWork W2163349720 @default.
- W3041729595 hasRelatedWork W2338142079 @default.
- W3041729595 hasRelatedWork W2391850557 @default.
- W3041729595 hasRelatedWork W2407169661 @default.
- W3041729595 hasRelatedWork W2898646785 @default.
- W3041729595 hasRelatedWork W3022260604 @default.
- W3041729595 hasRelatedWork W3125724402 @default.
- W3041729595 hasRelatedWork W3202058017 @default.
- W3041729595 hasRelatedWork W35859246 @default.
- W3041729595 hasRelatedWork W632800365 @default.
- W3041729595 hasRelatedWork W953738836 @default.
- W3041729595 hasRelatedWork W1964385957 @default.
- W3041729595 hasVolume "71" @default.
- W3041729595 isParatext "false" @default.
- W3041729595 isRetracted "false" @default.
- W3041729595 magId "3041729595" @default.
- W3041729595 workType "article" @default.