Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041736262> ?p ?o ?g. }
Showing items 1 to 56 of
56
with 100 items per page.
- W3041736262 endingPage "324" @default.
- W3041736262 startingPage "323" @default.
- W3041736262 abstract "Lymphangioleiomyomatosis is an interstitial, cystic lung disease that destroys the lung parenchyma, ultimately leading to respiratory failure. This disease affects females almost exclusively. Only two long-term treatment options exist: 1) single or bilateral lung transplant, which only slows the disease as the newly-transplanted lungs will soon succumb to the disease, and 2) rapamycin (Rapamune), a costly mTOR inhibitor that may result in multiple side effects and is not always tolerated by users. We sought to examine if moderate- to high-intensity exercise could slow or reverse the pulmonary decline seen with LAM. PURPOSE: To determine if a three-month exercise intervention had a positive impact in women with LAM. METHODS: Eight women with LAM (aged 27-60) were recruited to participate in an in-person exercise training intervention consisting of moderate- to high-intensity aerobic and anaerobic exercise. Prior to the study VO2max was assessed, as well as pulmonary function (FEV1, FVC, FEV1/FVC, and peak flow) and bone mineral density (BMD). After three months these measures were again tested. RESULTS: After three months of training, VO2max increased 12% from baseline (p=0.06). FEV1 improved by 4%. While this was not statistically significant (p=0.19) this is nonetheless substantial, as this is the primary clinical measure used to assess a decline in pulmonary function. This is also the first non-pharmaceutical study to demonstrate an increase, rather than a decline, in lung function. Peak flow also improved by 11% (p=0.18). BMD also slightly improved over three months (p=0.12), also significant as LAM patients have been shown to demonstrate a loss of BMD at a five-fold increase compared with healthy females. Though underpowered, this is the first non-pharmaceutical intervention study to show improved exercise tolerance, lung function, and bone health in women with LAM." @default.
- W3041736262 created "2020-07-16" @default.
- W3041736262 creator A5008709175 @default.
- W3041736262 date "2020-07-01" @default.
- W3041736262 modified "2023-09-26" @default.
- W3041736262 title "Exercise To Treat Women With Pulmonary Lymphangioleiomyomatosis (LAM)" @default.
- W3041736262 doi "https://doi.org/10.1249/01.mss.0000677144.19352.29" @default.
- W3041736262 hasPublicationYear "2020" @default.
- W3041736262 type Work @default.
- W3041736262 sameAs 3041736262 @default.
- W3041736262 citedByCount "0" @default.
- W3041736262 crossrefType "journal-article" @default.
- W3041736262 hasAuthorship W3041736262A5008709175 @default.
- W3041736262 hasBestOaLocation W30417362621 @default.
- W3041736262 hasConcept C103038586 @default.
- W3041736262 hasConcept C126322002 @default.
- W3041736262 hasConcept C164705383 @default.
- W3041736262 hasConcept C1862650 @default.
- W3041736262 hasConcept C2777543607 @default.
- W3041736262 hasConcept C2777714996 @default.
- W3041736262 hasConcept C2779997425 @default.
- W3041736262 hasConcept C5140985 @default.
- W3041736262 hasConcept C71924100 @default.
- W3041736262 hasConcept C75603125 @default.
- W3041736262 hasConceptScore W3041736262C103038586 @default.
- W3041736262 hasConceptScore W3041736262C126322002 @default.
- W3041736262 hasConceptScore W3041736262C164705383 @default.
- W3041736262 hasConceptScore W3041736262C1862650 @default.
- W3041736262 hasConceptScore W3041736262C2777543607 @default.
- W3041736262 hasConceptScore W3041736262C2777714996 @default.
- W3041736262 hasConceptScore W3041736262C2779997425 @default.
- W3041736262 hasConceptScore W3041736262C5140985 @default.
- W3041736262 hasConceptScore W3041736262C71924100 @default.
- W3041736262 hasConceptScore W3041736262C75603125 @default.
- W3041736262 hasIssue "7S" @default.
- W3041736262 hasLocation W30417362621 @default.
- W3041736262 hasLocation W30417362622 @default.
- W3041736262 hasOpenAccess W3041736262 @default.
- W3041736262 hasPrimaryLocation W30417362621 @default.
- W3041736262 hasRelatedWork W1995293612 @default.
- W3041736262 hasRelatedWork W2011818327 @default.
- W3041736262 hasRelatedWork W2042031275 @default.
- W3041736262 hasRelatedWork W2104384006 @default.
- W3041736262 hasRelatedWork W2782684474 @default.
- W3041736262 hasRelatedWork W3007963219 @default.
- W3041736262 hasRelatedWork W3091903385 @default.
- W3041736262 hasRelatedWork W3210863073 @default.
- W3041736262 hasRelatedWork W4220850451 @default.
- W3041736262 hasRelatedWork W2287861750 @default.
- W3041736262 hasVolume "52" @default.
- W3041736262 isParatext "false" @default.
- W3041736262 isRetracted "false" @default.
- W3041736262 magId "3041736262" @default.
- W3041736262 workType "article" @default.