Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041751306> ?p ?o ?g. }
- W3041751306 abstract "Abstract Background Parkinson’s disease (PD) is a disease of the central nervous system that progressively affects the motor system. Epidemiological studies have provided evidence that exposure to agriculture-related occupations or agrichemicals elevate a person’s risk for PD. Here, we sought to examine the possible epigenetic changes associated with working on a plantation on Oahu, HI and/or exposure to organochlorines (OGC) in PD cases. Results We measured genome-wide DNA methylation using the Illumina Infinium HumanMethylation450K BeadChip array in matched peripheral blood and postmortem brain biospecimens in PD cases (n = 20) assessed for years of plantation work and presence of organochlorines in brain tissue. The comparison of 10+ to 0 years of plantation work exposure detected 7 and 123 differentially methylated loci (DML) in brain and blood DNA, respectively ( p < 0.0001). The comparison of cases with 4+ to 0–2 detectable levels of OGCs, identified 8 and 18 DML in brain and blood DNA, respectively ( p < 0.0001). Pathway analyses revealed links to key neurotoxic and neuropathologic pathways related to impaired immune and proinflammatory responses as well as impaired clearance of damaged proteins, as found in the predominantly glial cell population in these environmental exposure-related PD cases. Conclusions These results suggest that distinct DNA methylation biomarker profiles related to environmental exposures in PD cases with previous exposure can be found in both brain and blood." @default.
- W3041751306 created "2020-07-16" @default.
- W3041751306 creator A5009648410 @default.
- W3041751306 creator A5014295522 @default.
- W3041751306 creator A5058972938 @default.
- W3041751306 creator A5061871901 @default.
- W3041751306 creator A5064296356 @default.
- W3041751306 creator A5065958472 @default.
- W3041751306 creator A5087563406 @default.
- W3041751306 creator A5088482571 @default.
- W3041751306 date "2020-07-10" @default.
- W3041751306 modified "2023-10-18" @default.
- W3041751306 title "Genome-wide epigenetic analyses in Japanese immigrant plantation workers with Parkinson’s disease and exposure to organochlorines reveal possible involvement of glial genes and pathways involved in neurotoxicity" @default.
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