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• W3041757748 abstract "PURPOSE: Autophagy is a degradation system where damaged cellular components can be recycled, resulting in higher cellular efficiency. White adipose tissue has been shown to have a catabolic response to exercise where autophagy will increase immediately after exercise. mTOR is an anabolic signaling pathway that inhibits autophagy, and plays a key role regulating cell size. Autophagy is sensitive to bioenergetic stressors such as exercise and has been shown to be regulated in a circadian fashion. However, it is currently unknown if exercise-induced autophagy is sensitive to the time-of-day at which exercise occurs. The purpose was to assess anabolic and catabolic signaling in white adipose tissue following exercise at two times of day; Zeitgeber time (ZT) 0 (light phase) and ZT12 (dark phase). METHODS: 21 week old male C57/BL6 mice (n=38) were habituated to treadmill exercise for 5 days under red light during the active phase, and allowed to recover for 2 days. Following a single 60-minute bout of treadmill exercise at 10 m/min, mice were sacrificed at 3 time points, pre exercise (SED), immediately post exercise (POST), and 1-hour post exercise (1HR). Tissue was analyzed for anabolic (p-mTOR (Ser2448) and p-S6 (Ser240/244)), and catabolic (LC3II/I) signaling pathways via western blotting. Results were analyzed with a 2x3 ANOVA and significance was accepted at p<0.05. RESULTS: Following exercise, there was a significant repression of mTOR (SED=0.990 ±0.17 vs POST=0.747 ± 0.14, p<0.05) and S6 (SED=0.702 ± 0.39 vs POST=0.186 ± 0.14, p<0.05) activation (Main Effect (ME) Exercise; p<0.05, both), which was significantly stronger following exercise performed at ZT12 (Interaction Effect for p-S6;; p<0.05). Autophagy signaling (LC3II/I) was increased at ZT12 (ZT0=1.22 ± 0.33 vs ZT12=2.28 ± 1.09, p<0.05), which appeared to be driven by changes in LC3I expression. LC3II (normalized to total protein) was increased following exercise (SED=0.81 ± 0.26 vs POST=1.28 ± 0.43 and 1HR=1.22 ± 0.28, p<0.05, both) and was higher at ZT0 (ZT0=1.33 ± 0.33 vs ZT12=0.91 ± 0.33, p<0.05), although no interaction was present. CONCLUSION: Anabolic and catabolic signaling in adipose tissue may be differentially impacted by exercise performed at different times of day." @default.
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• W3041757748 date "2020-07-01" @default.
• W3041757748 modified "2023-09-27" @default.
• W3041757748 title "Diurnal Regulation Of Exercise-induced Anabolic And Catabolic Signaling In White Adipose Tissue" @default.
• W3041757748 doi "https://doi.org/10.1249/01.mss.0000685540.93044.44" @default.
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