FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041776779> ?p ?o ?g. }

• W3041776779 abstract "Abstract Background Long-term benzodiazepine (BZD) use may lead to dependence, addiction, and neuropsychiatric disturbances. BZD discontinuation can cause severe withdrawal symptoms and resurgence of premorbid conditions. There are guidelines on how to stop BZD if it is necessary. Pharmacological management is an option among several other recommendations, but its benefit remains unclear. This study investigates whether certain pharmacological classes can manage or facilitate BZD withdrawal beyond BZD itself. Methods Data collected from (1985 to 2018) in Google Scholar, Medline Ovid, Scopus, PsychInfo, ClinicalTrials.gov, Cochrane Review Database, Embase, Scopus, Pubmed, and Proquest databases: involved controlled clinical trials on drugs studied for BZD withdrawal discontinuation. Single drugs were clustered into their pharmacological class (domain). The Oxford Quality Scoring System assessed the quality of a trial. The GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) was used for clinical practice recommendations. For publication bias, we visually inspected the Funnel plot. We adopted the Cochrane Risk of Bias Tool to assess biases inherent to individual trials. The standardized mean difference measured the magnitude of the benefit of a pharmacological class. Results We analyzed forty-nine controlled trials of 2815 assigned participants. Of fourteen classes, the BZD receptor antagonist class (d 0.671, CI 0.199 -1.143, p=0.005, I 2 =0),5-HT1A receptor partial agonist, and the glutamate class seemed to have the potentiality to manage BZD withdrawal discontinuation clinically. Around 61 % of the trials received an Oxford Quality score of three, 86% of the trials were granted a GRADE recommendation low. About 29 trials were at low risk of bias in general. Conclusions Even though we could not prove that the pharmacological classes of drugs we analyzed for the clinical management of BZD withdrawal discontinuation were efficacious, our investigation showed that some of these classes have the potentiality to manage BZD withdrawal discontinuation and clinically facilitate the process when it is necessary, relevant, and recommended based on established guidelines. Further investigations are warranted to support our findings." @default.
• W3041776779 created "2020-07-16" @default.
• W3041776779 creator A5010880318 @default.
• W3041776779 creator A5016762658 @default.
• W3041776779 creator A5083878749 @default.
• W3041776779 creator A5085114214 @default.
• W3041776779 date "2020-07-10" @default.
• W3041776779 modified "2023-09-26" @default.
• W3041776779 title "Pharmacological class interventions for benzodiazepine withdrawal discontinuation: a meta-analysis" @default.
• W3041776779 cites W1486315929 @default.
• W3041776779 cites W1552653847 @default.
• W3041776779 cites W1575307708 @default.
• W3041776779 cites W1589111048 @default.
• W3041776779 cites W1592645113 @default.
• W3041776779 cites W1682943049 @default.
• W3041776779 cites W1689430984 @default.
• W3041776779 cites W1965829294 @default.
• W3041776779 cites W1966408042 @default.
• W3041776779 cites W1969612147 @default.
• W3041776779 cites W1976321075 @default.
• W3041776779 cites W1978296118 @default.
• W3041776779 cites W1978539730 @default.
• W3041776779 cites W1978718865 @default.
• W3041776779 cites W1980843180 @default.
• W3041776779 cites W1981776119 @default.
• W3041776779 cites W1982344701 @default.
• W3041776779 cites W1984208027 @default.
• W3041776779 cites W1992643698 @default.
• W3041776779 cites W1995179943 @default.
• W3041776779 cites W2007168079 @default.
• W3041776779 cites W2007645247 @default.
• W3041776779 cites W2007872832 @default.
• W3041776779 cites W2020005761 @default.
• W3041776779 cites W2033856902 @default.
• W3041776779 cites W2035384587 @default.
• W3041776779 cites W2036895589 @default.
• W3041776779 cites W2037568976 @default.
• W3041776779 cites W2040418863 @default.
• W3041776779 cites W2041124713 @default.
• W3041776779 cites W2044368843 @default.
• W3041776779 cites W2044709796 @default.
• W3041776779 cites W2065747869 @default.
• W3041776779 cites W2068677212 @default.
• W3041776779 cites W2072672004 @default.
• W3041776779 cites W2083921747 @default.
• W3041776779 cites W2087980352 @default.
• W3041776779 cites W2091589270 @default.
• W3041776779 cites W2091919635 @default.
• W3041776779 cites W2092335293 @default.
• W3041776779 cites W2092914302 @default.
• W3041776779 cites W2094089029 @default.
• W3041776779 cites W2097536190 @default.
• W3041776779 cites W2107328434 @default.
• W3041776779 cites W2108608442 @default.
• W3041776779 cites W2114226116 @default.
• W3041776779 cites W2114928716 @default.
• W3041776779 cites W2116029648 @default.
• W3041776779 cites W2116273170 @default.
• W3041776779 cites W2117228789 @default.
• W3041776779 cites W2117896059 @default.
• W3041776779 cites W2129411932 @default.
• W3041776779 cites W2129632383 @default.
• W3041776779 cites W2139904895 @default.
• W3041776779 cites W2151756295 @default.
• W3041776779 cites W2160797858 @default.
• W3041776779 cites W2165010366 @default.
• W3041776779 cites W2301693649 @default.
• W3041776779 cites W2302737370 @default.
• W3041776779 cites W2323718767 @default.
• W3041776779 cites W2337498844 @default.
• W3041776779 cites W2337557559 @default.
• W3041776779 cites W2399493679 @default.
• W3041776779 cites W2558084536 @default.
• W3041776779 cites W2594625773 @default.
• W3041776779 cites W2598429061 @default.
• W3041776779 cites W2610021354 @default.
• W3041776779 cites W2790115166 @default.
• W3041776779 cites W2793017265 @default.
• W3041776779 cites W2793983403 @default.
• W3041776779 cites W2896792095 @default.
• W3041776779 cites W2927696747 @default.
• W3041776779 cites W2945116445 @default.
• W3041776779 cites W635630645 @default.
• W3041776779 doi "https://doi.org/10.1101/2020.07.07.20148403" @default.
• W3041776779 hasPublicationYear "2020" @default.
• W3041776779 type Work @default.
• W3041776779 sameAs 3041776779 @default.
• W3041776779 citedByCount "0" @default.
• W3041776779 crossrefType "posted-content" @default.
• W3041776779 hasAuthorship W3041776779A5010880318 @default.
• W3041776779 hasAuthorship W3041776779A5016762658 @default.
• W3041776779 hasAuthorship W3041776779A5083878749 @default.
• W3041776779 hasAuthorship W3041776779A5085114214 @default.
• W3041776779 hasBestOaLocation W30417767791 @default.
• W3041776779 hasConcept C118552586 @default.
• W3041776779 hasConcept C126322002 @default.
• W3041776779 hasConcept C168563851 @default.
• W3041776779 hasConcept C170493617 @default.
• W3041776779 hasConcept C17744445 @default.
• W3041776779 hasConcept C197934379 @default.

• next