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• W3041796688 abstract "The anti-inflammatory property of ratite oils as well as its ability to act as a penetration enhancer makes it an ideal agent to be used in transdermal formulations. The present study aims to develop an effective transfersomal delivery of 4-hydroxytamoxifen (4-OHT), an anti-cancer drug, using ratite oil as a carrier agent for the treatment of breast cancer (BC). The 4-OHT transfersomes were prepared with and without ratite oils using soy phosphatidylcholine and three different edge activators (EAs) in five different molar ratios using the rotary evaporation-ultrasonication method. Optimal transfersome formulations were selected using physical-chemical characterization and ex vivo studies. Results from physical-chemical characterization of the developed formulations found sodium taurocholate to be the most suitable EA, which recorded highest entrapment efficiency of 95.1 ± 2.70% with 85:15, (w/w) and lowest vesicle size of 82.3 ± 0.02 nm with 75:25, (w/w) molar ratios. TEM and DSC studies showed that the vesicles were readily identified and present in a nearly perfect spherical shape. In addition, formulations with emu oil had better stability than formulations with ostrich oil. Physical stability studies at 4 °C showed that ratite oil transfersomes were stable up to 4 weeks, while transfersomes without ratite oils were stable for 8 weeks. Ex vivo permeability studies using porcine skin concluded that 4-OHT transfersomal formulations with (85:15, w/w) without emu oil have the potential to be used in transdermal delivery approach to enhance permeation of 4-OHT, which may be beneficial in the treatment of BC." @default.
• W3041796688 created "2020-07-16" @default.
• W3041796688 creator A5050802043 @default.
• W3041796688 creator A5058592400 @default.
• W3041796688 creator A5072088724 @default.
• W3041796688 creator A5077771427 @default.
• W3041796688 date "2020-08-30" @default.
• W3041796688 modified "2023-09-27" @default.
• W3041796688 title "Ratite oils for local transdermal therapy of 4-OH tamoxifen: development, characterization, and <i>ex vivo</i> evaluation" @default.
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• W3041796688 doi "https://doi.org/10.1080/08982104.2020.1777155" @default.
• W3041796688 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32648792" @default.
• W3041796688 hasPublicationYear "2020" @default.
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