FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041844545> ?p ?o ?g. }

• W3041844545 endingPage "381" @default.
• W3041844545 startingPage "375" @default.
• W3041844545 abstract "In the last months great efforts have been developed to evaluate the more efficient therapeutic agents in the management of patients with COVID-19. Currently, no specific drug combination has consistently demonstrated an association with mortality. The aim of this study was to assess the pattern of associations observed between the different in-hospital treatments administered to a series of 238 patients admitted for COVID-19 and their relationship with mortality. The electronic medical records of patients that discharged or died from COVID-19 in the Hospital Universitario San Cecilio (Granada, Spain) between March 16 and April 10, 2020 were analysed. From these records, information was obtained on sex, age, comorbidities at admission, clinical information, analytical parameters, imaging tests and empirical treatments used. The outcome variable was the in-hospital mortality. To estimate the associations between the different therapeutic alternatives and the risk of mortality, Hazard Ratios adjusted for age, sex, previous pathologies and severity at discharge were estimated using Cox Regression models. The most frequently used combination of drugs was low molecular weight heparins, hydroxychloroquine, and ritonavir/lopinavir. None of the analysed treatments showed independent association with mortality. The drugs that showed a greater inverse association with mortality were tocilizumab and corticoids. The observed association patterns are consistent with previous literature. It seems necessary to design randomized controlled clinical trials that evaluate the possible protector effect of tocilizumab and corticoids in the risk of mortality for some subgroups of COVID-19 hospitalized patients. En los últimos meses se han realizado grandes esfuerzos para evaluar las terapias más eficaces en el manejo de pacientes con COVID-19. Actualmente ninguna combinación ha demostrado de manera consistente una relación clara con la mortalidad. Nuestro objetivo fue valorar el patrón de asociaciones observado entre los distintos tratamientos intrahospitalarios administrados a 238 pacientes ingresados por COVID-19 y la mortalidad. Se analizaron las historias clínicas electrónicas de aquellos pacientes dados de alta o que fallecieron por COVID-19 entre el 16 de marzo y el 10 de abril de 2020 en el Hospital Universitario San Cecilio (Granada, España). Se obtuvo información sobre sexo, edad, comorbilidades al ingreso, parámetros clínicos, analíticos, pruebas de imagen y tratamientos empíricos empleados. La variable de desenlace fue la mortalidad intrahospitalaria. Para estimar las asociaciones entre los diferentes tratamientos y el riesgo de mortalidad se estimaron, mediante modelos de regresión de Cox, hazard ratio ajustadas por edad, sexo, patologías previas y gravedad al ingreso. La combinación de fármacos más frecuentemente empleada fue la formada por heparinade bajo peso molecular (HBPM), hidroxicloroquina y ritonavir/lopinavir. Ninguno de los tratamientos utilizados mostró una asociación independiente con la mortalidad. Los fármacos que mostraron una asociación inversa de mayor magnitud fueron el tocilizumab y los corticoides. El patrón se asociaciones obtenido es consistente con lo reportado en la bibliografía. Parece oportuno diseñar ensayos aleatorizados que valoren el posible efecto protector de los corticoides y el tocilizumab sobre el riesgo de muerte en algunos subgrupos de pacientes hospitalizados por COVID-19." @default.
• W3041844545 created "2020-07-16" @default.
• W3041844545 creator A5000657763 @default.
• W3041844545 creator A5005560749 @default.
• W3041844545 creator A5007505846 @default.
• W3041844545 creator A5009675744 @default.
• W3041844545 creator A5010305553 @default.
• W3041844545 creator A5016148497 @default.
• W3041844545 creator A5016588220 @default.
• W3041844545 creator A5018264749 @default.
• W3041844545 creator A5019656171 @default.
• W3041844545 creator A5032587001 @default.
• W3041844545 creator A5034660696 @default.
• W3041844545 creator A5039501099 @default.
• W3041844545 creator A5041968387 @default.
• W3041844545 creator A5059847648 @default.
• W3041844545 creator A5066890863 @default.
• W3041844545 creator A5078392217 @default.
• W3041844545 creator A5082793632 @default.
• W3041844545 creator A5086274611 @default.
• W3041844545 creator A5086835128 @default.
• W3041844545 creator A5089137154 @default.
• W3041844545 date "2020-11-01" @default.
• W3041844545 modified "2023-10-16" @default.
• W3041844545 title "Therapeutic agents tested in 238 COVID-19 hospitalized patients and their relationship with mortality" @default.
• W3041844545 cites W3001118548 @default.
• W3041844545 cites W3004878749 @default.
• W3041844545 cites W3004919484 @default.
• W3041844545 cites W3005212621 @default.
• W3041844545 cites W3005403371 @default.
• W3041844545 cites W3008526620 @default.
• W3041844545 cites W3008763357 @default.
• W3041844545 cites W3008827533 @default.
• W3041844545 cites W3009567932 @default.
• W3041844545 cites W3009577418 @default.
• W3041844545 cites W3009828946 @default.
• W3041844545 cites W3010930696 @default.
• W3041844545 cites W3010992334 @default.
• W3041844545 cites W3012379316 @default.
• W3041844545 cites W3013306614 @default.
• W3041844545 cites W3013336676 @default.
• W3041844545 cites W3013899502 @default.
• W3041844545 cites W3014203610 @default.
• W3041844545 cites W3014333693 @default.
• W3041844545 cites W3014502060 @default.
• W3041844545 cites W3014524604 @default.
• W3041844545 cites W3014962324 @default.
• W3041844545 cites W3015016176 @default.
• W3041844545 cites W3015323620 @default.
• W3041844545 cites W3015993909 @default.
• W3041844545 cites W3016084006 @default.
• W3041844545 cites W3016143592 @default.
• W3041844545 cites W3016620140 @default.
• W3041844545 cites W3017790741 @default.
• W3041844545 cites W3018023298 @default.
• W3041844545 cites W3019394879 @default.
• W3041844545 cites W3021915688 @default.
• W3041844545 cites W3022970339 @default.
• W3041844545 cites W3023002160 @default.
• W3041844545 cites W3023346879 @default.
• W3041844545 cites W3027630905 @default.
• W3041844545 cites W3031597737 @default.
• W3041844545 cites W3091988413 @default.
• W3041844545 doi "https://doi.org/10.1016/j.medcle.2020.06.024" @default.
• W3041844545 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7546238" @default.
• W3041844545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33072869" @default.
• W3041844545 hasPublicationYear "2020" @default.
• W3041844545 type Work @default.
• W3041844545 sameAs 3041844545 @default.
• W3041844545 citedByCount "1" @default.
• W3041844545 countsByYear W30418445452021 @default.
• W3041844545 crossrefType "journal-article" @default.
• W3041844545 hasAuthorship W3041844545A5000657763 @default.
• W3041844545 hasAuthorship W3041844545A5005560749 @default.
• W3041844545 hasAuthorship W3041844545A5007505846 @default.
• W3041844545 hasAuthorship W3041844545A5009675744 @default.
• W3041844545 hasAuthorship W3041844545A5010305553 @default.
• W3041844545 hasAuthorship W3041844545A5016148497 @default.
• W3041844545 hasAuthorship W3041844545A5016588220 @default.
• W3041844545 hasAuthorship W3041844545A5018264749 @default.
• W3041844545 hasAuthorship W3041844545A5019656171 @default.
• W3041844545 hasAuthorship W3041844545A5032587001 @default.
• W3041844545 hasAuthorship W3041844545A5034660696 @default.
• W3041844545 hasAuthorship W3041844545A5039501099 @default.
• W3041844545 hasAuthorship W3041844545A5041968387 @default.
• W3041844545 hasAuthorship W3041844545A5059847648 @default.
• W3041844545 hasAuthorship W3041844545A5066890863 @default.
• W3041844545 hasAuthorship W3041844545A5078392217 @default.
• W3041844545 hasAuthorship W3041844545A5082793632 @default.
• W3041844545 hasAuthorship W3041844545A5086274611 @default.
• W3041844545 hasAuthorship W3041844545A5086835128 @default.
• W3041844545 hasAuthorship W3041844545A5089137154 @default.
• W3041844545 hasBestOaLocation W30418445451 @default.
• W3041844545 hasConcept C126322002 @default.
• W3041844545 hasConcept C179755657 @default.
• W3041844545 hasConcept C194828623 @default.
• W3041844545 hasConcept C195910791 @default.
• W3041844545 hasConcept C207103383 @default.

• next