Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041861850> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W3041861850 endingPage "2346" @default.
- W3041861850 startingPage "2341" @default.
- W3041861850 abstract ": Leptomeningeal metastasis (LM) is one of the most severe complications of non-small cell lung cancer (NSCLC), and it lacks standard treatment guidelines and is always accompanied by poor prognosis. We report a patient who was definitively diagnosed as LM from NSCLC with a targeted mutation of epidermal growth factor receptor (EGFR) via magnetic resonance imaging (MRI) and positive cerebrospinal fluid (CSF) cytology. Tyrosine kinase inhibitors (TKIs) were implemented but ineffective. Then the patient received the installation of an intraventricular Ommaya reservoir. Thirty mg of pemetrexed and other adjuvant treatments were implemented on days 1 and 8 every 3 weeks via the Ommaya reservoir. This treatment regimen resulted in the alleviation of the neurological symptoms, the clearing of CSF cytology and a reduced lesion of LM without notable side effects. At recent follow-ups, MRI examinations revealed the sustained stable LM lesion. We report the first successful example of administering intrathecal chemotherapy with pemetrexed via an Ommaya reservoir, providing a new therapeutic approach against LM from NSCLC." @default.
- W3041861850 created "2020-07-16" @default.
- W3041861850 creator A5000952543 @default.
- W3041861850 creator A5002189428 @default.
- W3041861850 creator A5009324842 @default.
- W3041861850 creator A5057076853 @default.
- W3041861850 creator A5058628358 @default.
- W3041861850 creator A5061976160 @default.
- W3041861850 creator A5080440228 @default.
- W3041861850 creator A5082139492 @default.
- W3041861850 creator A5088304835 @default.
- W3041861850 date "2020-07-01" @default.
- W3041861850 modified "2023-10-16" @default.
- W3041861850 title "Treatment response to intrathecal chemotherapy with pemetrexed via an Ommaya reservoir in EGFR-mutated leptomeningeal metastases from non-small cell lung cancer: a case report" @default.
- W3041861850 cites W1769635431 @default.
- W3041861850 cites W1937707643 @default.
- W3041861850 cites W1976138879 @default.
- W3041861850 cites W1998621572 @default.
- W3041861850 cites W2009261997 @default.
- W3041861850 cites W2055309515 @default.
- W3041861850 cites W2065073049 @default.
- W3041861850 cites W2099635182 @default.
- W3041861850 cites W2160313599 @default.
- W3041861850 cites W2342032414 @default.
- W3041861850 cites W2494292000 @default.
- W3041861850 cites W2513221119 @default.
- W3041861850 cites W2561905602 @default.
- W3041861850 cites W2776743180 @default.
- W3041861850 cites W2803149877 @default.
- W3041861850 cites W2805868473 @default.
- W3041861850 cites W605487159 @default.
- W3041861850 cites W2510104963 @default.
- W3041861850 doi "https://doi.org/10.21037/apm-19-521" @default.
- W3041861850 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32648459" @default.
- W3041861850 hasPublicationYear "2020" @default.
- W3041861850 type Work @default.
- W3041861850 sameAs 3041861850 @default.
- W3041861850 citedByCount "4" @default.
- W3041861850 countsByYear W30418618502021 @default.
- W3041861850 countsByYear W30418618502023 @default.
- W3041861850 crossrefType "journal-article" @default.
- W3041861850 hasAuthorship W3041861850A5000952543 @default.
- W3041861850 hasAuthorship W3041861850A5002189428 @default.
- W3041861850 hasAuthorship W3041861850A5009324842 @default.
- W3041861850 hasAuthorship W3041861850A5057076853 @default.
- W3041861850 hasAuthorship W3041861850A5058628358 @default.
- W3041861850 hasAuthorship W3041861850A5061976160 @default.
- W3041861850 hasAuthorship W3041861850A5080440228 @default.
- W3041861850 hasAuthorship W3041861850A5082139492 @default.
- W3041861850 hasAuthorship W3041861850A5088304835 @default.
- W3041861850 hasBestOaLocation W30418618501 @default.
- W3041861850 hasConcept C121608353 @default.
- W3041861850 hasConcept C126322002 @default.
- W3041861850 hasConcept C126838900 @default.
- W3041861850 hasConcept C143409427 @default.
- W3041861850 hasConcept C143998085 @default.
- W3041861850 hasConcept C2776256026 @default.
- W3041861850 hasConcept C2776694085 @default.
- W3041861850 hasConcept C2777240266 @default.
- W3041861850 hasConcept C2778239845 @default.
- W3041861850 hasConcept C2779438470 @default.
- W3041861850 hasConcept C2779651940 @default.
- W3041861850 hasConcept C2781393001 @default.
- W3041861850 hasConcept C71924100 @default.
- W3041861850 hasConceptScore W3041861850C121608353 @default.
- W3041861850 hasConceptScore W3041861850C126322002 @default.
- W3041861850 hasConceptScore W3041861850C126838900 @default.
- W3041861850 hasConceptScore W3041861850C143409427 @default.
- W3041861850 hasConceptScore W3041861850C143998085 @default.
- W3041861850 hasConceptScore W3041861850C2776256026 @default.
- W3041861850 hasConceptScore W3041861850C2776694085 @default.
- W3041861850 hasConceptScore W3041861850C2777240266 @default.
- W3041861850 hasConceptScore W3041861850C2778239845 @default.
- W3041861850 hasConceptScore W3041861850C2779438470 @default.
- W3041861850 hasConceptScore W3041861850C2779651940 @default.
- W3041861850 hasConceptScore W3041861850C2781393001 @default.
- W3041861850 hasConceptScore W3041861850C71924100 @default.
- W3041861850 hasIssue "4" @default.
- W3041861850 hasLocation W30418618501 @default.
- W3041861850 hasOpenAccess W3041861850 @default.
- W3041861850 hasPrimaryLocation W30418618501 @default.
- W3041861850 hasRelatedWork W2027821191 @default.
- W3041861850 hasRelatedWork W2167650070 @default.
- W3041861850 hasRelatedWork W2290188865 @default.
- W3041861850 hasRelatedWork W2358450743 @default.
- W3041861850 hasRelatedWork W2606568050 @default.
- W3041861850 hasRelatedWork W2768988395 @default.
- W3041861850 hasRelatedWork W3011176692 @default.
- W3041861850 hasRelatedWork W3029430426 @default.
- W3041861850 hasRelatedWork W3082709647 @default.
- W3041861850 hasRelatedWork W4254666574 @default.
- W3041861850 hasVolume "9" @default.
- W3041861850 isParatext "false" @default.
- W3041861850 isRetracted "false" @default.
- W3041861850 magId "3041861850" @default.
- W3041861850 workType "article" @default.