Matches in SemOpenAlex for { <https://semopenalex.org/work/W3041943364> ?p ?o ?g. }
- W3041943364 endingPage "3179" @default.
- W3041943364 startingPage "3169" @default.
- W3041943364 abstract "Abstract Transplant-associated thrombotic microangiopathy (TA-TMA) is a fatal complication of allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, so far, no large cohort study determined the risk factors and the most effective therapeutic strategies for TA-TMA. Thus, the present study aimed to clarify these clinical aspects based on a large multicenter cohort. This retrospective cohort study was performed by the Kyoto Stem Cell Transplantation Group (KSCTG). A total of 2425 patients were enrolled from 14 institutions. All patients were aged ≥16 years, presented with hematological diseases, and received allo-HSCT after the year 2000. TA-TMA was observed in 121 patients (5.0%) on day 35 (median) and was clearly correlated with inferior overall survival (OS) (hazard ratio [HR], 4.93). Pre- and post-HSCT statistically significant risk factors identified by multivariate analyses included poorer performance status (HR, 1.69), HLA mismatch (HR, 2.17), acute graft-versus-host disease (aGVHD; grades 3-4) (HR, 4.02), Aspergillus infection (HR, 2.29), and veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS; HR, 4.47). The response rate and OS significantly better with the continuation or careful reduction of calcineurin inhibitors (CNI) than the conventional treatment strategy of switching from CNI to corticosteroids (response rate, 64.7% vs 20.0%). In summary, we identified the risk factors and the most appropriate therapeutic strategies for TA-TMA. The described treatment strategy could improve the outcomes of patients with TA-TMA in the future." @default.
- W3041943364 created "2020-07-16" @default.
- W3041943364 creator A5003005479 @default.
- W3041943364 creator A5008228398 @default.
- W3041943364 creator A5017171769 @default.
- W3041943364 creator A5020234186 @default.
- W3041943364 creator A5021783559 @default.
- W3041943364 creator A5026760618 @default.
- W3041943364 creator A5032508712 @default.
- W3041943364 creator A5037832946 @default.
- W3041943364 creator A5038408710 @default.
- W3041943364 creator A5038837090 @default.
- W3041943364 creator A5039784657 @default.
- W3041943364 creator A5044291196 @default.
- W3041943364 creator A5048379630 @default.
- W3041943364 creator A5052615919 @default.
- W3041943364 creator A5058058394 @default.
- W3041943364 creator A5061453456 @default.
- W3041943364 creator A5067597137 @default.
- W3041943364 creator A5072808833 @default.
- W3041943364 creator A5083955022 @default.
- W3041943364 creator A5089002578 @default.
- W3041943364 creator A5089860514 @default.
- W3041943364 date "2020-07-13" @default.
- W3041943364 modified "2023-10-17" @default.
- W3041943364 title "Risk factors and appropriate therapeutic strategies for thrombotic microangiopathy after allogeneic HSCT" @default.
- W3041943364 cites W1779344217 @default.
- W3041943364 cites W1859210543 @default.
- W3041943364 cites W1972172571 @default.
- W3041943364 cites W1986077158 @default.
- W3041943364 cites W2010802708 @default.
- W3041943364 cites W2037119492 @default.
- W3041943364 cites W2047010928 @default.
- W3041943364 cites W2048009057 @default.
- W3041943364 cites W2048984662 @default.
- W3041943364 cites W2052963776 @default.
- W3041943364 cites W2053278212 @default.
- W3041943364 cites W2085290177 @default.
- W3041943364 cites W2093903773 @default.
- W3041943364 cites W2094076572 @default.
- W3041943364 cites W2095078549 @default.
- W3041943364 cites W2106449858 @default.
- W3041943364 cites W2112756201 @default.
- W3041943364 cites W2125312770 @default.
- W3041943364 cites W2167765664 @default.
- W3041943364 cites W2297424987 @default.
- W3041943364 cites W2528374605 @default.
- W3041943364 cites W2645692333 @default.
- W3041943364 cites W2798240688 @default.
- W3041943364 cites W2887339279 @default.
- W3041943364 cites W2887792780 @default.
- W3041943364 cites W2897515101 @default.
- W3041943364 cites W2898432878 @default.
- W3041943364 cites W2960694113 @default.
- W3041943364 cites W2967174380 @default.
- W3041943364 doi "https://doi.org/10.1182/bloodadvances.2020002007" @default.
- W3041943364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7362379" @default.
- W3041943364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32658984" @default.
- W3041943364 hasPublicationYear "2020" @default.
- W3041943364 type Work @default.
- W3041943364 sameAs 3041943364 @default.
- W3041943364 citedByCount "13" @default.
- W3041943364 countsByYear W30419433642020 @default.
- W3041943364 countsByYear W30419433642021 @default.
- W3041943364 countsByYear W30419433642022 @default.
- W3041943364 countsByYear W30419433642023 @default.
- W3041943364 crossrefType "journal-article" @default.
- W3041943364 hasAuthorship W3041943364A5003005479 @default.
- W3041943364 hasAuthorship W3041943364A5008228398 @default.
- W3041943364 hasAuthorship W3041943364A5017171769 @default.
- W3041943364 hasAuthorship W3041943364A5020234186 @default.
- W3041943364 hasAuthorship W3041943364A5021783559 @default.
- W3041943364 hasAuthorship W3041943364A5026760618 @default.
- W3041943364 hasAuthorship W3041943364A5032508712 @default.
- W3041943364 hasAuthorship W3041943364A5037832946 @default.
- W3041943364 hasAuthorship W3041943364A5038408710 @default.
- W3041943364 hasAuthorship W3041943364A5038837090 @default.
- W3041943364 hasAuthorship W3041943364A5039784657 @default.
- W3041943364 hasAuthorship W3041943364A5044291196 @default.
- W3041943364 hasAuthorship W3041943364A5048379630 @default.
- W3041943364 hasAuthorship W3041943364A5052615919 @default.
- W3041943364 hasAuthorship W3041943364A5058058394 @default.
- W3041943364 hasAuthorship W3041943364A5061453456 @default.
- W3041943364 hasAuthorship W3041943364A5067597137 @default.
- W3041943364 hasAuthorship W3041943364A5072808833 @default.
- W3041943364 hasAuthorship W3041943364A5083955022 @default.
- W3041943364 hasAuthorship W3041943364A5089002578 @default.
- W3041943364 hasAuthorship W3041943364A5089860514 @default.
- W3041943364 hasBestOaLocation W30419433641 @default.
- W3041943364 hasConcept C126322002 @default.
- W3041943364 hasConcept C128057223 @default.
- W3041943364 hasConcept C141071460 @default.
- W3041943364 hasConcept C167135981 @default.
- W3041943364 hasConcept C207103383 @default.
- W3041943364 hasConcept C2777408962 @default.
- W3041943364 hasConcept C2777878052 @default.
- W3041943364 hasConcept C2779134260 @default.
- W3041943364 hasConcept C2911091166 @default.