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• W3042079074 abstract "Studies of families and twins show the importance of genetic factors affecting susceptibility to bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN. Strong evidence exists for a polygenic contribution to risk (ie, many risk alleles of small effect). A notable finding is the overlap of susceptibility between bipolar disorder and schizophrenia for several individual risk alleles and for the polygenic risk. By contrast, genomic structural variation seems to play a smaller part in bipolar disorder than it does in schizophrenia. Together, these genetic findings suggest directions for future studies to delineate the aetiology and pathogenesis of bipolar disorder, indicate the need to re-evaluate our diagnostic classifications, and might eventually pave the way for major improvements in clinical management. Studies of families and twins show the importance of genetic factors affecting susceptibility to bipolar disorder and suggest substantial genetic and phenotypic complexity. Robust and replicable genome-wide significant associations have recently been reported in genome-wide association studies at several common polymorphisms, including variants within the genes CACNA1C, ODZ4, and NCAN. Strong evidence exists for a polygenic contribution to risk (ie, many risk alleles of small effect). A notable finding is the overlap of susceptibility between bipolar disorder and schizophrenia for several individual risk alleles and for the polygenic risk. By contrast, genomic structural variation seems to play a smaller part in bipolar disorder than it does in schizophrenia. Together, these genetic findings suggest directions for future studies to delineate the aetiology and pathogenesis of bipolar disorder, indicate the need to re-evaluate our diagnostic classifications, and might eventually pave the way for major improvements in clinical management. Diagnosis of bipolar disorder: who is in a mixed state?Mixed states have long contributed to the concept of manic-depressive illness.1,2 Defined broadly as the coexistence of depressive and manic features within the same mood episode, the criteria for mixed states have narrowed in successive editions of the Diagnostic and Statistical Manual for Mental Disorders (DSM) I to IV from manic-depressive reaction mixed type, to mixed episodes. However, in DSM-5, this trend has been reversed and the mixed episode diagnosis replaced by a mixed features specifier (MxFS). Full-Text PDF Nick Craddock: a world leader in psychiatric geneticsNick Craddock says that he cannot imagine a more rewarding job than the one he has now, as Director of the National Centre for Mental Health at Cardiff University, UK. “My work is challenging, but the desire for new knowledge and to help people with often very complex psychiatric problems, and my chosen path in academic psychiatry, is all incredibly rewarding.” And advancing knowledge of bipolar disorder and other mood and psychotic illness is central to this work. Full-Text PDF" @default.
• W3042079074 created "2020-07-16" @default.
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• W3042079074 date "2013-05-01" @default.
• W3042079074 modified "2023-10-18" @default.
• W3042079074 title "Genetics of bipolar disorder" @default.
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• W3042079074 doi "https://doi.org/10.1016/s0140-6736(13)60855-7" @default.
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