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• W3042110588 startingPage "106427" @default.
• W3042110588 abstract "Orphan and conventional kinesin dimers represent two families of the kinesin superfamily molecular motors. Conventional kinesin, having a 14-residue neck linker (NL) in each head, can step processively on microtubule (MT), with an ATP hydrolysis being coupled with a mechanical stepping under no load. Orphan kinesin phragmoplast-associated kinesin-related protein 2 (PAKRP2) dimer, despite having a NL of 32 residues in each head, can also step processively on MT and exhibits tight chemomechanical coupling under no load. However, the dynamic properties of the wild type PAKRP2 and the mutant one with each NL truncated to 14 residues are very different from those of the wild type conventional kinesin and the mutant one with each NL being replaced by the 32-residue NL from PAKRP2. Here, based on a common chemomechanical coupling model we study computationally the dynamics of the two families of the kinesin dimers, with the simulated results explaining quantitatively the available experimental data. The large differences in the dynamics between the two families of kinesin dimers arise mainly from different rate constants of NL docking and ATPase activity and different weak affinities of the head in ADP state for MT. The studies indicate that both the orphan kinesin PAKRP2 and conventional kinesin use the same mechanism for processive motility." @default.
• W3042110588 created "2020-07-16" @default.
• W3042110588 creator A5026658937 @default.
• W3042110588 creator A5083698715 @default.
• W3042110588 date "2020-09-01" @default.
• W3042110588 modified "2023-10-16" @default.
• W3042110588 title "A common chemomechanical coupling model for orphan and conventional kinesin molecular motors" @default.
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• W3042110588 doi "https://doi.org/10.1016/j.bpc.2020.106427" @default.
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• W3042110588 hasPublicationYear "2020" @default.
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