Matches in SemOpenAlex for { <https://semopenalex.org/work/W30421115> ?p ?o ?g. }
Showing items 1 to 68 of
68
with 100 items per page.
- W30421115 abstract "Biomolekulak mikrospeciacioja Az elő vilag sokfelesegenek egyik oka, hogy ugyanazon molekula tobbfele toltessel es szerkezettel (azaz mikroreszecske, mikrospecies formajaban) fordulhat elő es vehet reszt az egyes kemiai es biokemiai folyamatokban, valtozatos reakciotermekeket eredmenyezve. E nanosecundum egyedi elettartamu, egymasba folytonosan atalakulo, ezert elvalaszthatatlan, csak kozvetett modszerekkel vizsgalhato reszecskek koncentraciojanak es tulajdonsagainak meghatarozasaban (mikrospeciaciojaban) - tobbek kozt - megvalositottuk: Uj tipusu, az irodalomban le nem irt mikroszkopikus fizikai-kemiai mennyisegek bevezeteset (rotamer-specifikus megoszlasi hanyados, eszter hidrolizis sebessegi mikroallando) Elettani vagy gyogyszertani jelentősegű molekulak jellemzeset reszecske-specifikus parameterekkel (stressz elleni glutation, magzatvedő folsav, tumorgatlo metotrexat es imatinib, kohogescsillapito folkodin, penicillin es kefalosporin antibiotikumok, gyulladasgatlo tenoxikam, stb.) A mikro- es szubmikro speciacio korebe tartozo elvi kerdesek tisztazasat (mikroallandok es rotamer populaciok NMR-alapu meghatarozasanak kritikai ertekelese, az első irodalmi negycsoportos mikrospeciacio, a hisztamin biologiai kemiaja). Eredmenyeink vilagszinvonalu nemzetkozi folyoiratokban kaptak nyilvanossagot (J. Med. Chem., J. Phys. Chem. B, Anal. Bioanal. Chem., Eur. J. Pharm, Electrophoresis, stb.) | MICROSPECIATION OF BIOMOLECULES The chemical and biological diversity of the world stems partly from the fact that the molecules - especially the bio- and drug molecules - occur and react in various forms of protonation and conformation (i.e. microspecies), resulting in a cornucopia of products. Microspecies are of nanoseconds individual lifetime, which makes them inseparable, coexisting ones. In the research of their analytical determination and physicochemical characterization (i.e. microspeciation) our results include: Introduction and determination of previously undefined microscopic physicochemical quantities (rotamer-specific partition coefficient, microscopic rate constants of ester hydrolysis) Characterization of bio- and drug molecules in terms of species-specific parameters (anti-stress glutathione, fetus-protective folic acid, anti-cancer methotrexate and imatinib, anti inflammatory tenoxicame, penicilline and cephalosporine antibiotics, glutamate receptor ligand NMDA, etc.) Elucidation of some principal questions concerning microspeciation (critical reviews on NMR methods to evaluate microconstants and rotamer populations, microscopic characterization of a tetradentate ligand for the first time, the biological chemistry of histamine) Our results appeared in world-class journals of the field (J. Med. Chem., J. Phys. Chem. B, Anal. Bioanal. Chem., Eur. J. Pharm, Electrophoresis, etc.)" @default.
- W30421115 created "2016-06-24" @default.
- W30421115 creator A5011326231 @default.
- W30421115 creator A5018923620 @default.
- W30421115 creator A5024564610 @default.
- W30421115 creator A5030208047 @default.
- W30421115 creator A5034145752 @default.
- W30421115 creator A5036366502 @default.
- W30421115 creator A5039562373 @default.
- W30421115 creator A5051500156 @default.
- W30421115 creator A5073519039 @default.
- W30421115 creator A5086371482 @default.
- W30421115 date "2007-01-01" @default.
- W30421115 modified "2023-09-30" @default.
- W30421115 title "Biomolekulák mikrospeciációja = Microspeciation and Biomolecules" @default.
- W30421115 hasPublicationYear "2007" @default.
- W30421115 type Work @default.
- W30421115 sameAs 30421115 @default.
- W30421115 citedByCount "0" @default.
- W30421115 crossrefType "journal-article" @default.
- W30421115 hasAuthorship W30421115A5011326231 @default.
- W30421115 hasAuthorship W30421115A5018923620 @default.
- W30421115 hasAuthorship W30421115A5024564610 @default.
- W30421115 hasAuthorship W30421115A5030208047 @default.
- W30421115 hasAuthorship W30421115A5034145752 @default.
- W30421115 hasAuthorship W30421115A5036366502 @default.
- W30421115 hasAuthorship W30421115A5039562373 @default.
- W30421115 hasAuthorship W30421115A5051500156 @default.
- W30421115 hasAuthorship W30421115A5073519039 @default.
- W30421115 hasAuthorship W30421115A5086371482 @default.
- W30421115 hasConcept C145148216 @default.
- W30421115 hasConcept C178790620 @default.
- W30421115 hasConcept C185592680 @default.
- W30421115 hasConcept C18705241 @default.
- W30421115 hasConcept C30095370 @default.
- W30421115 hasConcept C32909587 @default.
- W30421115 hasConcept C49853544 @default.
- W30421115 hasConcept C55493867 @default.
- W30421115 hasConcept C71240020 @default.
- W30421115 hasConceptScore W30421115C145148216 @default.
- W30421115 hasConceptScore W30421115C178790620 @default.
- W30421115 hasConceptScore W30421115C185592680 @default.
- W30421115 hasConceptScore W30421115C18705241 @default.
- W30421115 hasConceptScore W30421115C30095370 @default.
- W30421115 hasConceptScore W30421115C32909587 @default.
- W30421115 hasConceptScore W30421115C49853544 @default.
- W30421115 hasConceptScore W30421115C55493867 @default.
- W30421115 hasConceptScore W30421115C71240020 @default.
- W30421115 hasLocation W304211151 @default.
- W30421115 hasOpenAccess W30421115 @default.
- W30421115 hasPrimaryLocation W304211151 @default.
- W30421115 hasRelatedWork W1011087368 @default.
- W30421115 hasRelatedWork W101370217 @default.
- W30421115 hasRelatedWork W1026832617 @default.
- W30421115 hasRelatedWork W1041540435 @default.
- W30421115 hasRelatedWork W1042496447 @default.
- W30421115 hasRelatedWork W154335387 @default.
- W30421115 hasRelatedWork W155186963 @default.
- W30421115 hasRelatedWork W359739026 @default.
- W30421115 hasRelatedWork W431554445 @default.
- W30421115 hasRelatedWork W563668995 @default.
- W30421115 hasRelatedWork W82301685 @default.
- W30421115 hasRelatedWork W951274497 @default.
- W30421115 hasRelatedWork W969988895 @default.
- W30421115 isParatext "false" @default.
- W30421115 isRetracted "false" @default.
- W30421115 magId "30421115" @default.
- W30421115 workType "article" @default.