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- W3042148907 abstract "Multiple sclerosis (MS) is a central nervous system inflammatory demyelinating disease and the most common cause of non-traumatic disability in young adults. Despite progress in the treatment of the active relapsing disease, therapeutic options targeting irreversible progressive decline remain limited. Studies using skin fibroblasts derived from patients with neurodegenerative disorders demonstrate that cell stress pathways and bioenergetics are altered when compared to healthy individuals. However, findings in MS skin fibroblasts are limited. Here, we collected skin fibroblasts from 24 healthy control individuals, 30 patients with MS, and ten with amyotrophic lateral sclerosis (ALS) to investigate altered cell stress profiles. We observed endoplasmic reticulum swelling in MS skin fibroblasts, and increased gene expression of cell stress markers including BIP, ATF4, CHOP, GRP94, P53, and P21. When challenged against hydrogen peroxide, MS skin fibroblasts had reduced resiliency compared to ALS and controls. Mitochondrial and glycolytic functions were perturbed in MS skin fibroblasts while exhibiting a significant increase in lactate production over ALS and controls. Our results suggest that MS skin fibroblasts have an underlying stress phenotype, which may be disease specific. Interrogating MS skin fibroblasts may provide patient specific molecular insights and aid in prognosis, diagnosis, and therapeutic testing enhancing individualized medicine." @default.
- W3042148907 created "2020-07-16" @default.
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- W3042148907 date "2020-07-08" @default.
- W3042148907 modified "2023-10-18" @default.
- W3042148907 title "Signatures of cell stress and altered bioenergetics in skin fibroblasts from patients with multiple sclerosis" @default.
- W3042148907 cites W1524549603 @default.
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- W3042148907 cites W1755032422 @default.
- W3042148907 cites W1871573964 @default.
- W3042148907 cites W1890354534 @default.
- W3042148907 cites W1930183105 @default.
- W3042148907 cites W1968431957 @default.
- W3042148907 cites W1974825648 @default.
- W3042148907 cites W1975175488 @default.
- W3042148907 cites W1975182142 @default.
- W3042148907 cites W1990782273 @default.
- W3042148907 cites W1996772579 @default.
- W3042148907 cites W2009741382 @default.
- W3042148907 cites W2013234597 @default.
- W3042148907 cites W2018487770 @default.
- W3042148907 cites W2024399152 @default.
- W3042148907 cites W2027226224 @default.
- W3042148907 cites W2027366885 @default.
- W3042148907 cites W2049020904 @default.
- W3042148907 cites W2051661723 @default.
- W3042148907 cites W2059769914 @default.
- W3042148907 cites W2073143133 @default.
- W3042148907 cites W2073833993 @default.
- W3042148907 cites W2084994800 @default.
- W3042148907 cites W2086047469 @default.
- W3042148907 cites W2092814619 @default.
- W3042148907 cites W2107277218 @default.
- W3042148907 cites W2112286580 @default.
- W3042148907 cites W2130458932 @default.
- W3042148907 cites W2131391897 @default.
- W3042148907 cites W2135141709 @default.
- W3042148907 cites W2160822774 @default.
- W3042148907 cites W2161068028 @default.
- W3042148907 cites W2180696344 @default.
- W3042148907 cites W2193792657 @default.
- W3042148907 cites W2239053864 @default.
- W3042148907 cites W2265894166 @default.
- W3042148907 cites W2272462464 @default.
- W3042148907 cites W2331721074 @default.
- W3042148907 cites W2398660216 @default.
- W3042148907 cites W2426149297 @default.
- W3042148907 cites W2461952548 @default.
- W3042148907 cites W2597603553 @default.
- W3042148907 cites W2618219849 @default.
- W3042148907 cites W2752428554 @default.
- W3042148907 cites W2763147694 @default.
- W3042148907 cites W2763364508 @default.
- W3042148907 cites W2766700447 @default.
- W3042148907 cites W2766751114 @default.
- W3042148907 cites W2775627975 @default.
- W3042148907 cites W2784329444 @default.
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- W3042148907 cites W2791870944 @default.
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- W3042148907 cites W2885069150 @default.
- W3042148907 cites W2887456892 @default.
- W3042148907 cites W2889708457 @default.
- W3042148907 cites W2892390537 @default.
- W3042148907 cites W2913940235 @default.
- W3042148907 cites W2920380346 @default.
- W3042148907 cites W2923125845 @default.
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- W3042148907 cites W2943993219 @default.
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- W3042148907 doi "https://doi.org/10.18632/aging.103612" @default.
- W3042148907 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7425440" @default.
- W3042148907 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32640422" @default.
- W3042148907 hasPublicationYear "2020" @default.
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