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- W3042152090 abstract "Abstract Rapid evolution and propagation of multidrug resistance among bacterial pathogens are outpacing the development of new antibiotics, but antimicrobial photodynamic therapy (aPDT) provides an excellent alternative. This treatment depends on the interaction between light and photoactivated sensitizer to generate reactive oxygen species (ROS), which are highly cytotoxic to induce apoptosis in virtually all microorganisms without resistance concern. When replacing light with low-frequency ultrasonic wave to activate sensitizer, a novel ultrasound-driven treatment emerges as antimicrobial sonodynamic therapy (aSDT). Recent advances in aPDT and aSDT reveal golden opportunities for the management of multidrug resistant bacterial infections, especially in the theranostic application where imaging diagnosis can be accomplished facilely with the inherent optical characteristics of sensitizers, and the generated ROS by aPDT/SDT cause broad-spectrum oxidative damage for sterilization. In this review, we systemically outline the mechanisms, targets, and current progress of aPDT/SDT for bacterial theranostic application. Furthermore, potential limitations and future perspectives are also highlighted." @default.
- W3042152090 created "2020-07-16" @default.
- W3042152090 creator A5000170594 @default.
- W3042152090 creator A5030287019 @default.
- W3042152090 creator A5031128531 @default.
- W3042152090 creator A5058637832 @default.
- W3042152090 creator A5074097453 @default.
- W3042152090 date "2020-07-10" @default.
- W3042152090 modified "2023-10-16" @default.
- W3042152090 title "Beyond Antibiotics: Photo/Sonodynamic Approaches for Bacterial Theranostics" @default.
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