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• W3042163073 startingPage "1035" @default.
• W3042163073 abstract "The aim of the present research is to investigate the efficacy of L-carnitine (LC) as a complementary therapy to diclofenac sodium (Dic) treatment in a mono-iodoacetate (MIA) induced knee osteoarthritis (OA) rat model, with respect to pain relief and the underlying pathology.Fifty adult male albino rats were randomly divided into five groups (n=10): Control, OA, OA/Dic, OA/LC, and OA/Dic+LC. Knee diameter and pain assessment tests were done weekly. After four weeks, serum malondialdehyde, reduced glutathione, interleukin 1-β, tumor necrosis factor-alpha, prostaglandin E2, and bone-specific alkaline phosphatase were measured. The injected knees were removed and processed for the histological and immunohistological study of matrix metalloproteinase-13 (MMP-13) and cyclooxygenase 2 (COX-2). Also, histological examination of dorsal root ganglia and calcitonin gene-related peptide (CGRP) expression in the spinal cord were assessed.Treatment with Dic and/or LC significantly reduced knee swelling, improved pain-related behaviors, inflammatory and oxidative stress markers, attenuated the MIA-mediated histopathological alteration in the knee joint, and down-regulated expression of MMP-13 and COX-2 in the knee joint. It, also, significantly reduced CGRP expression, compared with the OA group. Dic+LC showed a better effect in improving some parameters than each treatment alone.LC plus Dic is a more effective therapy than Dic alone for OA treatment." @default.
• W3042163073 created "2020-07-16" @default.
• W3042163073 creator A5013176645 @default.
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• W3042163073 date "2020-08-01" @default.
• W3042163073 modified "2023-09-23" @default.
• W3042163073 title "L-Carnitine potentiates the anti-inflammatory and antinociceptive effects of diclofenac sodium in an experimentally-induced knee osteoarthritis rat model." @default.
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• W3042163073 doi "https://doi.org/10.22038/ijbms.2020.43136.10138" @default.
• W3042163073 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7478254" @default.
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• W3042163073 hasPublicationYear "2020" @default.
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