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- W3042174902 abstract "Fenugreek is a popular spice which has been evaluated for hormone related disorders. The present randomized, double-blinded, placebo-controlled study investigated the effect of a unique extract of fenugreek (FHE), at a dose of 250 mg × 2/day for 42 days on hormone balance and postmenopausal discomforts. Postmenopausal women (n = 48) having characteristic postmenopausal symptoms, as assessed by MRS questionnaire, were randomized either to FHE (n = 24) or placebo (n = 24) groups. The FHE-treated participants reported the feel of well-being within two weeks of supplementation and further improvement was observed in somatic, psychological and urogenital scores towards the end of the study period. There were 2.9, 4.2 and 7.2 times reduction respectively in hot flashes, night sweats and pain on leg muscles and joints with significant improvement in irritability and vaginal dryness when compared to placebo. Hormone analysis revealed significant increase in estradiol, free testosterone, progesterone and decrease in FSH, SHBG and CTX-1 concentrations, though within the safe range, indicating the trend towards attaining a hormonal balance. Supplementation of FHE regulated various hormones in postmenopausal women and offered a significant reduction in vasomotor effects and leg pain without showing any significant variations in hematological and biochemical parameters." @default.
- W3042174902 created "2020-07-16" @default.
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- W3042174902 date "2020-12-01" @default.
- W3042174902 modified "2023-09-27" @default.
- W3042174902 title "Phytoestrogenic effect of fenugreek seed extract helps in ameliorating the leg pain and vasomotor symptoms in postmenopausal women: A randomized, double-blinded, placebo-controlled study" @default.
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- W3042174902 doi "https://doi.org/10.1016/j.phanu.2020.100209" @default.
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