Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042203985> ?p ?o ?g. }
- W3042203985 endingPage "108463" @default.
- W3042203985 startingPage "108463" @default.
- W3042203985 abstract "The objective of this study was to develop a well-characterized mouse model of nonalcoholic steatohepatitis (NASH) with a strong manifestation of liver fibrosis. The progression of metabolic, inflammatory and fibrotic features of this mouse model was monitored by performing in vivo time-course study. Male C57BL/6J mice were fed a high-fat/high-sucrose/high-cholesterol diet (34% fat, 34% sucrose and 2.0% cholesterol, by weight) for 2, 4, 6, 8, 10, 12, 14 or 16 weeks to induce obesity-associated metabolic dysfunctions, inflammation and fibrosis in the liver and white adipose tissue (WAT). Body and liver weights were gradually increased with significant hepatic triglyceride accumulation, i.e., liver steatosis, and marked elevation of serum alanine transaminase levels at week 10. While hepatic inflammation was displayed with the highest expression of macrophage markers and M1 markers at week 6, liver fibrosis determined by collagen accumulation was continuously increased to week 16. In epididymal WAT, weights and adipocyte size peaked at week 6–8. The increased expression of fibrogenic genes preceded inflammatory features (week 2 to 6 vs. week 6 to 16), suggesting that early fibrosis may trigger inflammatory events in the WAT. This study established a mouse model of diet-induced NASH with a strong manifestation of liver fibrosis. This mouse model will be a valuable in vivo tool in studying the pathophysiology of NASH and also in testing preventive and therapeutic potentials of dietary components and drugs against NASH with liver fibrosis." @default.
- W3042203985 created "2020-07-16" @default.
- W3042203985 creator A5002218759 @default.
- W3042203985 creator A5011967545 @default.
- W3042203985 creator A5028516688 @default.
- W3042203985 creator A5053388117 @default.
- W3042203985 creator A5068002440 @default.
- W3042203985 creator A5080891156 @default.
- W3042203985 creator A5084009935 @default.
- W3042203985 creator A5087538716 @default.
- W3042203985 date "2020-11-01" @default.
- W3042203985 modified "2023-10-17" @default.
- W3042203985 title "Comprehensive characterization of metabolic, inflammatory and fibrotic changes in a mouse model of diet-derived nonalcoholic steatohepatitis" @default.
- W3042203985 cites W1699654400 @default.
- W3042203985 cites W1953103451 @default.
- W3042203985 cites W1967702906 @default.
- W3042203985 cites W1970136916 @default.
- W3042203985 cites W1986988638 @default.
- W3042203985 cites W1991552651 @default.
- W3042203985 cites W1994809630 @default.
- W3042203985 cites W2000369852 @default.
- W3042203985 cites W2014718725 @default.
- W3042203985 cites W2019317175 @default.
- W3042203985 cites W2019694067 @default.
- W3042203985 cites W2022790785 @default.
- W3042203985 cites W2035237584 @default.
- W3042203985 cites W2042823470 @default.
- W3042203985 cites W2047823058 @default.
- W3042203985 cites W2059992589 @default.
- W3042203985 cites W2065788317 @default.
- W3042203985 cites W2085170886 @default.
- W3042203985 cites W2085957571 @default.
- W3042203985 cites W2090286224 @default.
- W3042203985 cites W2101286220 @default.
- W3042203985 cites W2111115786 @default.
- W3042203985 cites W2113047132 @default.
- W3042203985 cites W2127865222 @default.
- W3042203985 cites W2134133526 @default.
- W3042203985 cites W21411052 @default.
- W3042203985 cites W2145323170 @default.
- W3042203985 cites W2148878254 @default.
- W3042203985 cites W2152113018 @default.
- W3042203985 cites W2162051951 @default.
- W3042203985 cites W2163691580 @default.
- W3042203985 cites W2167909421 @default.
- W3042203985 cites W2210672989 @default.
- W3042203985 cites W2289639638 @default.
- W3042203985 cites W2399693675 @default.
- W3042203985 cites W2406712574 @default.
- W3042203985 cites W2561860468 @default.
- W3042203985 cites W2594491387 @default.
- W3042203985 cites W2741683348 @default.
- W3042203985 cites W2765415318 @default.
- W3042203985 cites W2769501542 @default.
- W3042203985 cites W2771242823 @default.
- W3042203985 cites W2787530700 @default.
- W3042203985 cites W2906170017 @default.
- W3042203985 doi "https://doi.org/10.1016/j.jnutbio.2020.108463" @default.
- W3042203985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32891893" @default.
- W3042203985 hasPublicationYear "2020" @default.
- W3042203985 type Work @default.
- W3042203985 sameAs 3042203985 @default.
- W3042203985 citedByCount "6" @default.
- W3042203985 countsByYear W30422039852021 @default.
- W3042203985 countsByYear W30422039852022 @default.
- W3042203985 countsByYear W30422039852023 @default.
- W3042203985 crossrefType "journal-article" @default.
- W3042203985 hasAuthorship W3042203985A5002218759 @default.
- W3042203985 hasAuthorship W3042203985A5011967545 @default.
- W3042203985 hasAuthorship W3042203985A5028516688 @default.
- W3042203985 hasAuthorship W3042203985A5053388117 @default.
- W3042203985 hasAuthorship W3042203985A5068002440 @default.
- W3042203985 hasAuthorship W3042203985A5080891156 @default.
- W3042203985 hasAuthorship W3042203985A5084009935 @default.
- W3042203985 hasAuthorship W3042203985A5087538716 @default.
- W3042203985 hasConcept C126322002 @default.
- W3042203985 hasConcept C134018914 @default.
- W3042203985 hasConcept C151955695 @default.
- W3042203985 hasConcept C160160445 @default.
- W3042203985 hasConcept C171089720 @default.
- W3042203985 hasConcept C181199279 @default.
- W3042203985 hasConcept C2776175330 @default.
- W3042203985 hasConcept C2776914184 @default.
- W3042203985 hasConcept C2776954865 @default.
- W3042203985 hasConcept C2778606649 @default.
- W3042203985 hasConcept C2778772119 @default.
- W3042203985 hasConcept C2779134260 @default.
- W3042203985 hasConcept C2779478299 @default.
- W3042203985 hasConcept C2779679107 @default.
- W3042203985 hasConcept C2780559512 @default.
- W3042203985 hasConcept C55493867 @default.
- W3042203985 hasConcept C71924100 @default.
- W3042203985 hasConcept C86803240 @default.
- W3042203985 hasConceptScore W3042203985C126322002 @default.
- W3042203985 hasConceptScore W3042203985C134018914 @default.
- W3042203985 hasConceptScore W3042203985C151955695 @default.
- W3042203985 hasConceptScore W3042203985C160160445 @default.
- W3042203985 hasConceptScore W3042203985C171089720 @default.