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• W3042209315 endingPage "e9356" @default.
• W3042209315 startingPage "e9356" @default.
• W3042209315 abstract "The aquatic environment has been contaminated with various anthropogenic pollutants, including psychoactive compounds that may alter the physiology and behavior of free-living organisms. The present study focused on the condition and related mortality of the juvenile chub (Squalius cephalus). The aim of the study was to test whether the adverse effects of the antidepressants sertraline and citalopram, the analgesic tramadol and the illicit drug methamphetamine, on fish condition exist under environmentally relevant concentrations and whether these effects persist after a depuration period. Innovative analyses of the fish brain concentrations of these compounds were performed with the aim to show relationship between compound brain tissue concentration and fish condition.The laboratory experiment consisted of 42 days of exposure and a subsequent 14-day depuration period with regular monitoring of the condition and mortality of exposed and control fish. Identical methodology, including individual brain concentration analyses for the tested compounds, was applied for all substances. Additional study on feeding under sertraline exposure was also conducted. The feeding was measured from the 28th day of the exposure, three times in a week, by observation of food intake during 15 minutes in social environment.The effects of particular psychoactive compounds on chub condition varied. While sertraline induced a lower condition and increased mortality, the effects of methamphetamine were inverse, and tramadol and citalopram had no significant effect at all. Individual brain concentrations of the tested compounds showed that the effects of sertraline and methamphetamine on fish condition were increased with brain concentration increases. Additionally, the food intake was reduced in case of sertraline. In contrast, there was no relationship between tramadol and citalopram brain tissue concentration and fish condition, suggesting that the concentration-dependent effect is strongly compound-specific. Methamphetamine was the only compound with a persistent effect after the depuration period. Our results demonstrate the suitability of the brain concentration evidence approach and suggest that changes in fish condition and other related parameters can be expected in freshwater ecosystems polluted with specific psychoactive compounds." @default.
• W3042209315 created "2020-07-16" @default.
• W3042209315 creator A5007575968 @default.
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• W3042209315 creator A5067253807 @default.
• W3042209315 creator A5079476163 @default.
• W3042209315 creator A5002456236 @default.
• W3042209315 date "2020-07-09" @default.
• W3042209315 modified "2023-09-24" @default.
• W3042209315 title "Environmentally relevant levels of four psychoactive compounds vary in their effects on freshwater fish condition: a brain concentration evidence approach" @default.
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• W3042209315 doi "https://doi.org/10.7717/peerj.9356" @default.
• W3042209315 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7354837" @default.
• W3042209315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32714655" @default.
• W3042209315 hasPublicationYear "2020" @default.
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