Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042307316> ?p ?o ?g. }
- W3042307316 abstract "ABSTRACT Pyrimidine nucleotides are essential to plant development. We proved that Arabidopsis growth can be inhibited or enhanced by down- or upregulating aspartate transcarbamoylase (ATC), the first committed enzyme for de novo biosynthesis of pyrimidines in plants. To understand the unique mechanism of feedback inhibition of this enzyme by uridine 5-monophosphate (UMP), we determined the crystal structure of the Arabidopsis ATC trimer free and bound to UMP, demonstrating that the nucleotide binds and blocks the active site. The regulatory mechanism relies on a loop exclusively conserved in plants, and a single-point mutation (F161A) turns ATC insensitive to UMP. Moreover, the structures in complex with a transition-state analog or with carbamoyl phosphate proved a mechanism in plant ATCs for sequential firing of the active sites. The disclosure of the unique regulatory and catalytic properties suggests new strategies to modulate ATC activity and to control de novo pyrimidine synthesis and plant growth." @default.
- W3042307316 created "2020-07-23" @default.
- W3042307316 creator A5006011806 @default.
- W3042307316 creator A5014543221 @default.
- W3042307316 creator A5021324892 @default.
- W3042307316 creator A5029070143 @default.
- W3042307316 creator A5091692002 @default.
- W3042307316 date "2020-07-17" @default.
- W3042307316 modified "2023-09-30" @default.
- W3042307316 title "UMP inhibition and sequential firing in aspartate transcarbamoylase open ways to regulate plant growth" @default.
- W3042307316 cites W1499845281 @default.
- W3042307316 cites W1555002836 @default.
- W3042307316 cites W1557485885 @default.
- W3042307316 cites W1580814042 @default.
- W3042307316 cites W1874448345 @default.
- W3042307316 cites W1969046346 @default.
- W3042307316 cites W1969264932 @default.
- W3042307316 cites W1974692406 @default.
- W3042307316 cites W1976912443 @default.
- W3042307316 cites W1978796610 @default.
- W3042307316 cites W1989818342 @default.
- W3042307316 cites W1991439346 @default.
- W3042307316 cites W1992932809 @default.
- W3042307316 cites W1994173218 @default.
- W3042307316 cites W2000904056 @default.
- W3042307316 cites W2003677194 @default.
- W3042307316 cites W2005796147 @default.
- W3042307316 cites W2005973126 @default.
- W3042307316 cites W2006289458 @default.
- W3042307316 cites W2018225090 @default.
- W3042307316 cites W2022176546 @default.
- W3042307316 cites W2023996824 @default.
- W3042307316 cites W2024359272 @default.
- W3042307316 cites W2027830360 @default.
- W3042307316 cites W2030603688 @default.
- W3042307316 cites W2035505895 @default.
- W3042307316 cites W2039142366 @default.
- W3042307316 cites W2047465253 @default.
- W3042307316 cites W2050526911 @default.
- W3042307316 cites W2053213037 @default.
- W3042307316 cites W2056342195 @default.
- W3042307316 cites W2066243052 @default.
- W3042307316 cites W2072746018 @default.
- W3042307316 cites W2081970608 @default.
- W3042307316 cites W2091192245 @default.
- W3042307316 cites W2092540399 @default.
- W3042307316 cites W2096183596 @default.
- W3042307316 cites W2097671472 @default.
- W3042307316 cites W2103924847 @default.
- W3042307316 cites W2108921801 @default.
- W3042307316 cites W2113202990 @default.
- W3042307316 cites W2117715731 @default.
- W3042307316 cites W2124026197 @default.
- W3042307316 cites W2128896661 @default.
- W3042307316 cites W2135932405 @default.
- W3042307316 cites W2139886312 @default.
- W3042307316 cites W2143660875 @default.
- W3042307316 cites W2148371056 @default.
- W3042307316 cites W2158215557 @default.
- W3042307316 cites W2159211495 @default.
- W3042307316 cites W2163341755 @default.
- W3042307316 cites W2173108077 @default.
- W3042307316 cites W2180229411 @default.
- W3042307316 cites W2218755796 @default.
- W3042307316 cites W2399600318 @default.
- W3042307316 cites W2408554545 @default.
- W3042307316 cites W2409721639 @default.
- W3042307316 cites W2618191408 @default.
- W3042307316 cites W2965966058 @default.
- W3042307316 cites W2981466220 @default.
- W3042307316 cites W2999334526 @default.
- W3042307316 cites W2999946439 @default.
- W3042307316 cites W37422720 @default.
- W3042307316 cites W4248872320 @default.
- W3042307316 cites W6312680 @default.
- W3042307316 doi "https://doi.org/10.1101/2020.07.17.208231" @default.
- W3042307316 hasPublicationYear "2020" @default.
- W3042307316 type Work @default.
- W3042307316 sameAs 3042307316 @default.
- W3042307316 citedByCount "0" @default.
- W3042307316 crossrefType "posted-content" @default.
- W3042307316 hasAuthorship W3042307316A5006011806 @default.
- W3042307316 hasAuthorship W3042307316A5014543221 @default.
- W3042307316 hasAuthorship W3042307316A5021324892 @default.
- W3042307316 hasAuthorship W3042307316A5029070143 @default.
- W3042307316 hasAuthorship W3042307316A5091692002 @default.
- W3042307316 hasBestOaLocation W30423073161 @default.
- W3042307316 hasConcept C104317684 @default.
- W3042307316 hasConcept C143065580 @default.
- W3042307316 hasConcept C166342909 @default.
- W3042307316 hasConcept C178790620 @default.
- W3042307316 hasConcept C181199279 @default.
- W3042307316 hasConcept C185592680 @default.
- W3042307316 hasConcept C197248121 @default.
- W3042307316 hasConcept C200159599 @default.
- W3042307316 hasConcept C2776403692 @default.
- W3042307316 hasConcept C2776476023 @default.
- W3042307316 hasConcept C2779491563 @default.
- W3042307316 hasConcept C2779546866 @default.
- W3042307316 hasConcept C41183919 @default.