Matches in SemOpenAlex for { <https://semopenalex.org/work/W3042336063> ?p ?o ?g. }
- W3042336063 endingPage "1904" @default.
- W3042336063 startingPage "1904" @default.
- W3042336063 abstract "A subset of oral carcinomas is etiologically related to high-risk human papillomavirus (HR-HPV) infection, with HPV16 being the most frequent HR-HPV type found in these carcinomas. The oncogenic role of HR-HPV is strongly dependent on the overexpression of E6 and E7 oncoproteins, which, in turn, induce p53 and pRb degradation, respectively. Additionally, it has been suggested that HR-HPV oncoproteins are involved in the regulation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), inducing cancer progression and metastasis. Previously, we reported that HPV16 E7 oncoprotein promotes Pirin upregulation resulting in increased epithelial–mesenchymal transition (EMT) and cell migration, with Pirin being an oxidative stress sensor and activator of NF-κB. In this study, we demonstrate the mechanism by which HPV16 E7-mediated Pirin overexpression occurs by promoting EGFR/PI3K/AKT1/NRF2 signaling, thus causing PIR/NF-κB activation in oral tumor cells. Our results demonstrate a new mechanism by which E7 contributes to oral cancer progression, proposing PIR as a potential new therapeutic target." @default.
- W3042336063 created "2020-07-23" @default.
- W3042336063 creator A5004519617 @default.
- W3042336063 creator A5006096067 @default.
- W3042336063 creator A5006933921 @default.
- W3042336063 creator A5009159645 @default.
- W3042336063 creator A5013413439 @default.
- W3042336063 creator A5016723784 @default.
- W3042336063 creator A5024246903 @default.
- W3042336063 creator A5025710517 @default.
- W3042336063 creator A5029828525 @default.
- W3042336063 creator A5035117288 @default.
- W3042336063 creator A5052133253 @default.
- W3042336063 creator A5077818597 @default.
- W3042336063 creator A5080077275 @default.
- W3042336063 creator A5091457383 @default.
- W3042336063 date "2020-07-15" @default.
- W3042336063 modified "2023-10-16" @default.
- W3042336063 title "Human Papillomavirus 16 E7 Promotes EGFR/PI3K/AKT1/NRF2 Signaling Pathway Contributing to PIR/NF-κB Activation in Oral Cancer Cells" @default.
- W3042336063 cites W1094547483 @default.
- W3042336063 cites W1510715774 @default.
- W3042336063 cites W1550041354 @default.
- W3042336063 cites W1611632861 @default.
- W3042336063 cites W1822745879 @default.
- W3042336063 cites W1845708584 @default.
- W3042336063 cites W1965627667 @default.
- W3042336063 cites W1966676297 @default.
- W3042336063 cites W1969524738 @default.
- W3042336063 cites W1971073604 @default.
- W3042336063 cites W1971240021 @default.
- W3042336063 cites W1978506977 @default.
- W3042336063 cites W1979811051 @default.
- W3042336063 cites W1982202785 @default.
- W3042336063 cites W1991395601 @default.
- W3042336063 cites W2007772627 @default.
- W3042336063 cites W2013243369 @default.
- W3042336063 cites W2016145981 @default.
- W3042336063 cites W2018646351 @default.
- W3042336063 cites W2022154540 @default.
- W3042336063 cites W2024073334 @default.
- W3042336063 cites W2029742967 @default.
- W3042336063 cites W2029826091 @default.
- W3042336063 cites W2036199480 @default.
- W3042336063 cites W2036285327 @default.
- W3042336063 cites W2039382131 @default.
- W3042336063 cites W2040115433 @default.
- W3042336063 cites W2049053145 @default.
- W3042336063 cites W2054917860 @default.
- W3042336063 cites W2059158933 @default.
- W3042336063 cites W2062045792 @default.
- W3042336063 cites W2078612444 @default.
- W3042336063 cites W2088254663 @default.
- W3042336063 cites W2089211835 @default.
- W3042336063 cites W2094863064 @default.
- W3042336063 cites W2096308522 @default.
- W3042336063 cites W2100761652 @default.
- W3042336063 cites W2117692326 @default.
- W3042336063 cites W2118441422 @default.
- W3042336063 cites W2120533083 @default.
- W3042336063 cites W2133636335 @default.
- W3042336063 cites W2141633208 @default.
- W3042336063 cites W2143019738 @default.
- W3042336063 cites W2149996048 @default.
- W3042336063 cites W2165279145 @default.
- W3042336063 cites W2191017992 @default.
- W3042336063 cites W2282180989 @default.
- W3042336063 cites W2398239432 @default.
- W3042336063 cites W2417577329 @default.
- W3042336063 cites W2761160116 @default.
- W3042336063 cites W2767483971 @default.
- W3042336063 cites W2782630985 @default.
- W3042336063 cites W2806339429 @default.
- W3042336063 cites W2906255492 @default.
- W3042336063 cites W2915497747 @default.
- W3042336063 cites W2925241965 @default.
- W3042336063 cites W2943537919 @default.
- W3042336063 cites W2950564916 @default.
- W3042336063 cites W2952438049 @default.
- W3042336063 doi "https://doi.org/10.3390/cancers12071904" @default.
- W3042336063 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7409273" @default.
- W3042336063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32679705" @default.
- W3042336063 hasPublicationYear "2020" @default.
- W3042336063 type Work @default.
- W3042336063 sameAs 3042336063 @default.
- W3042336063 citedByCount "11" @default.
- W3042336063 countsByYear W30423360632020 @default.
- W3042336063 countsByYear W30423360632021 @default.
- W3042336063 countsByYear W30423360632022 @default.
- W3042336063 countsByYear W30423360632023 @default.
- W3042336063 crossrefType "journal-article" @default.
- W3042336063 hasAuthorship W3042336063A5004519617 @default.
- W3042336063 hasAuthorship W3042336063A5006096067 @default.
- W3042336063 hasAuthorship W3042336063A5006933921 @default.
- W3042336063 hasAuthorship W3042336063A5009159645 @default.
- W3042336063 hasAuthorship W3042336063A5013413439 @default.
- W3042336063 hasAuthorship W3042336063A5016723784 @default.
- W3042336063 hasAuthorship W3042336063A5024246903 @default.
- W3042336063 hasAuthorship W3042336063A5025710517 @default.